Pregnenolone and Mood

Decreased levels of pregnenolone are strongly linked with depressed mood. [83-84] Because depression can be very challenging to treat, with current medications requiring months before its therapeutic effects are achieved, research into pregnenolone on mood can be a game-changer. Interestingly, clinical studies assessing the beneficial effects of pregnenolone on mood, depression, anxiety, and other mental disorders show positive results:
1. In women with bipolar disorders, elevated levels of pregnenolone are associated with stable mood state. [85]
2. Pregnenolone boosts mood through activation of neurocircuits that control emotion. [86]
3. Blocking pregnenolone production impairs social and emotional functioning. [87]
4. In patients with bipolar disorder, recurrent major depressive disorder, and history of substance abuse/dependence, pregnenolone administration reduces symptoms of depression. [88-90]
5. Depressive disorders are caused by neuronal abnormalities in brain microtubule function. [91] By boosting the production and stability of tubules, pregnenolone promotes growth of neurons, thus fighting depression. [92]
6. Individuals with generalized anxiety disorder appear to have lower levels of pregnenolone than those without anxiety. [93]
7. Preclinical findings suggest that pregnenolone plays a major role in anxiety and depression-regulatory mechanisms. [94-95]
8. Patients experiencing a depressive episode, either unipolar or bipolar type, had lower levels of pregnenolone than healthy controls. [96]
9. Pregnenolone administration reduces self-reported anxiety. [97]
10. In adults with autism spectrum disorder, pregnenolone reduces irritability. [98]
11. Pregnenolone enhances mood by activating the brain chemical GABA. [99]

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