Marijuana, also known as cannabis, is the most commonly used illegal drug in the world. While some states or countries permit its use, chronic marijuana administration can lead to serious side effects such as panic attack, intense anxious or fearful feelings and thoughts, and acute psychosis. With its neuroprotective properties, studies show that pregnenolone may help protect against the negative effects cannabis intoxication:
1. In rats, pregnenolone administration reduces several effects of cannabis in the brain. [110-111]
2. Pregnenolone does not only protect against cannabis intoxication but also treats cannabis addiction. 
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