The logic behind the cholesterol-lowering effect of pregnenolone is simple – it is manufactured directly from cholesterol. To put it simply, when pregnenolone levels increase, cholesterol levels decrease. Studies on pregnenolone support its cholesterol-lowering effects:
1. In rats, administration of cholesterol substrates increases pregnenolone synthesis, suggesting that cholesterol is vital for pregnenolone production. [113-114]
2. Other studies show that cholesterol is converted into pregnenolone via several mechanisms, thus reducing its levels in the body. [115-116]
3. A study conducted in guinea pigs shows that higher pregnenolone levels were associated with lower levels of low density lipoprotein (bad cholesterol). 
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