Progesterone and Headaches

For many women who are experiencing headaches, migraines may become more frequent and severe as they approach their menopausal years. This is because hormone levels fluctuate unevenly. While headaches and migraines during this time period can be debilitating, studies show that progesterone administration can be beneficial:
1. In majority of women, progesterone administration has a positive effect on the course of both migraines with aura (MA) and without aura (MO). [248]
2. Progesterone-only contraceptives are considered safe and effective in alleviating migraines in women. [249]
3. Progesterone therapy can be safely prescribed for women suffering from various types of headaches without any contraindications. [250]