Progesterone has potent anti-inflammatory properties that can help treat and prevent a wide array of inflammatory conditions. Numerous clinical trials suggest that progesterone fights inflammation through the following important mechanisms:
1. It suppresses NF-κB and MAPK activation, which in turn inhibits the production of proinflammatory markers like COX-2, IL-6, iNOS, and TNF-α. [26-31]
2. It enhances the synthesis of brain steroids. 
3. It inhibits vascular permeability and the formation of granulation tissue in the early phase of the inflammation. 
4. It reduces cellular inflammatory response. 
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