Progesterone and Mood

Stressful situations as well as advancing age can lead to low mood in both men and women. Interestingly, there is strong scientific evidence that supports the mood-enhancing effects of progesterone:
1. In women with symptoms of premenstrual syndrome (PMS), administration of the synthetic progesterone called progestin decreases anxiety. [105-107]
2. In women with depression associated with childbirth, progesterone administration successfully improves depressive symptoms. [108-114]
3. In healthy female volunteers, higher level of progesterone is associated with reduced fatigue, confusion and other markers of anxiety. [115]
4. Progesterone helps improve mood by increasing the levels of brain chemicals (neurotransmitters) such as dopamine and serotonin. [116-127]
5. Progesterone prevents depression-like behaviour in animal models of Parkinson’s disease by improving cognitive function. [128]
6. In rat models, progesterone significantly reduces anxiety behaviour. [129-135]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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