In both men and women, low progesterone levels may lead to insulin resistance, a condition in which the body doesn’t normally respond to the effects of insulin. If left untreated, insulin resistance can cause fatal diseases including diabetes, cancer, stroke, heart failure, and other debilitating conditions. Evidence suggests that progesterone reduces insulin and regulates blood sugar levels, thereby improving overall health:
1. In healthy women and women with premenstrual syndrome, increased progesterone levels are associated with lower blood sugar levels. 
2. Progesterone has a major role in controlling blood sugar levels possibly by affecting the levels of nitric oxide, a compound that helps improve blood circulation. 
3. Progesterone helps lower blood sugar levels by making more storage of glycogen, the principal storage form of glucose. 
4. In women, progesterone improves blood sugar metabolism. 
5. In animal models of diabetes, progesterone therapy normalizes blood sugar levels. 
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