Progesterone and Bone Health

Progesterone stimulates bone growth through several important mechanisms. Several lines of evidence suggest that progesterone supplementation can help maintain bone health:
1. In human bone cells, the administration of progesterone promotes bone formation by activating bone forming cells (osteoblasts). [58-60]
2. In postmenopausal women, progesterone supplementation decreases the risk of fractures. [61]
3. In postmenopausal women who had surgical removal of the uterus (hysterectomy), progesterone supplementation prevents osteoporotic fractures. [62-63]
4. In healthy women experiencing problems with fertility, progesterone supplementation increases bone mineral density (BMD). [64]
5. Progesterone improves bone health by interacting with bone-related molecules such as sclerostin, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF). [65-66]
6. In early postmenopausal women, progesterone supplementation prevents bone loss by decreasing bone breakdown. [67]
7. When combined with medications for bone loss, progesterone exerts greater increases in BMD. [68-70]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

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