Research indicates that tesofensine helps preserve cognitive health by indirectly potentiating cholinergic neurotransmission, which is a process wherein nerve cells relay messages to each other.  This has been proven to have beneficial effects on various areas of cognitive health, including learning, memory, and thinking skills. The following studies support this effect:
1. First clinical results of two small 4-week phase IIa trials performed in patients with mild Alzheimer’s disease (AD) showed that tesofensine treatment induced significant improvement in cognitive function. [20-21]
2. A growing body of research indicates that obesity is a major risk factor for cognitive impairment especially in the older population. [22-25] With its anti-obesity effect, tesofensine may help protect against cognitive impairment.
3. In a mouse model of Alzheimer’s disease, tesofensine administration decreased the brain concentrations of amyloid beta, which are abnormal protein aggregates and is the causative agent of the disease. 
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