Sustained treatment with tesofensine has been shown to improve overall mood through its antidepressant effect. Studies show that tesofensine affects mood by:
1. Increasing the levels of brain-derived neurotrophic factor (BDNF), thereby triggering an antidepressant effect. 
2. Triggering an anti-anxiety effect in obese patients with comorbid depression and anxiety symptoms. 
3. Increasing the levels of the neurotransmitters serotonin, noradrenaline, and dopamine. 
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