Thyroid Hormone and Cholesterol Levels

The body needs thyroid hormones in order to balance cholesterol production and elimination. In case of thyroid hormone deficiency, the body can’t make high-density lipoprotein or HDL (good cholesterol) and remove low-density lipoprotein or LDL (bad cholesterol) efficiently as usual. As a result, LDL builds up in the bloodstream which eventually leads to various debilitating diseases. Interestingly, researchers found that thyroid hormone exerts cholesterol-lowering properties which can help improve overall health:
1. In patients with hypothyroidism and increased total cholesterol, T4 replacement therapy improves cholesterol levels by decreasing elevated LDL fraction. [86-87]
2. In premenopausal women with hypothyroidism, combined T3 and T4 treatment appears to be more effective at improving cholesterol profile compared to monotherapy. [88]
3. In patients with hypothyroidism, T3 or T4 administration significantly decreases total cholesterol by improving lipid metabolism. [89]
4. In patients with primary hypothyroidism, administration of 10, 20, 25, or 50 micrograms of T3 daily on a monthly basis significantly reduces blood cholesterol levels. [90]
5. In hypothyroid patients, T3 administration thrice daily (0.5–1.5 mIU/L) reduces total cholesterol and LDL levels. [91]
6. In patients with hypothyroidism, T4 treatment at a dose of 1.6 microgram/kg body weight reduces total cholesterol and LDL levels. [92]
7. In hypothyroid patients and those with normal thyroid hormone levels, T4 treatment lowers total cholesterol levels. [93]
8. In patients with hypothyroidism, combination treatment of T3 and T4 appears to be more effective in reducing cholesterol and triglyceride levels. [94]
9. In patients with hypothyroidism, thyroid hormone replacement therapy significantly reduces lipid and LDL levels without any adverse side effects. [95]
10. In patients with hypothyroidism, T4 treatment reduces cholesterol levels by increasing LDL degradation. [96]
11. In preclinical human studies, the use of thyroid hormone analogs is associated with reduced total cholesterol, LDL cholesterol, and triglycerides. [97]
12. Long-term thyroid hormone replacement therapy lowers cholesterol levels by improving liver cholesterol metabolism. [98]
13. Thyroid hormone replacement therapy lowers cholesterol levels by dramatically increasing intestinal absorption of cholesterol. [99]

before after

At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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