Thyroid Hormone and Immune Function

“Thyroid hormone metabolism and thyroid status are strongly associated with various aspects of the immune response. This suggests that thyroid hormones play an important role in modulating the immune system response and preventing a wide array of infections. Increasing evidence strongly supports the immune-modulating properties of thyroid hormones:
1. Low circulating thyroid hormone levels are strongly associated with impaired immune function. [40-41]
2. In patients with thyroid disorders, thyroid hormone supplementation prevents inflammation and other damaging immune responses. [42]
3. In healthy men and women, combined T3 and T4 treatment improves markers of immunity. [43]
4. Thyroid hormone administration increases size and growth of cells in the thymus, an organ that produces T cells for the immune system. [44-45]
5. Thyroid hormones boost the activities of various immune cells such as monocytes, macrophages, natural killer cells, and white blood cells. [46-53]
6. Thyroid hormones improve immune function by increasing the production of antibodies and other cells of the immune system. [54-58]
7. Thyroid hormones strengthen the immune system by affecting cell-mediated immune responses. [59]
8. In mice, T4 treatment suppresses excessive immune response such as antibody synthesis and growth of white blood cells. [60]
9. In a cell-based study, T4 potentiates growth and reproduction of white blood cells, thereby boosting the immune response. [61]
10. In mice, both T3 and T4 treatment enhance natural killer cell activity. [62]

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