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Thyroid Hormone and Mood

Thyroid disease can affect overall mood – primarily causing depression, anxiety and low self-confidence. Generally, thyroid hormone levels have something to do with the severity of mood changes, with abnormally low levels associated with severely depressed mood. There is growing evidence that thyroid hormone replacement therapy may help boost mood in people with thyroid hormone deficiency:
1. In patients with mood disorders, thyroid hormones, usually in conjunction with standard medications, can be used to treat both manic and depressed phases of the condition. [17]
2. In patients who had undergone surgical removal of the thyroid (thyroidectomy), combined T3 and T4 hormone replacement improves mood. [18]
3. In patients with thyroid hormone deficiency, combination treatment of T3 and T4 significantly improves mood as well as quality of life. [19-34]
4. In patients with mood disorders, the use of T3 helps treat symptoms by accelerating the onset of action of antidepressant therapy and enhancing the effect of treatment. [35]
5. In patients with major depressive disorder and previous history of treatment-resistant depression, T3 supplementation is associated with a twofold greater likelihood of response to tricyclic antidepressant (TCA) therapy. [36-37]
6. In patients with bipolar depression, supplementation of standard treatment with high-dose T4 improves mood by affecting the function of certain brain areas. [38]
7. In patients with hypothyroidism, combination therapy of T3 and T4 appears to be effective in alleviating anxiety and depression compared to monotherapy. [39]

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At the age of 60, I look and feel better than I ever have in my entire life! Switching my health program and hormone replacement therapy regimen over to Genemedics was one of the best decisions I’ve ever made in my life! Genemedics and Dr George have significantly improved my quality of life and also dramatically improved my overall health. I hav...

- Nick Cassavetes, 60 yrs old

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