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Treats Migraines

There’s also increasing evidence supporting the pain-relieving properties of valproic acid:
1. In patients with chronic (recurring) migraines, valproic acid administration at daily doses of 500 to 600 mg reduced migraine frequency. [21]
2. Larger clinical trials confirmed the benefit of valproic acid on migraine attacks and the FDA approved the use of this drug. [22-23]
3. Valproic acid administration in patients with recurrent migraines was associated with better clinical response. [24]
4. A study found that low dose of valproic acid (10 mg/kg) for 6 months may be helpful in preventing migraine in pediatric patients. [25]
5. In patients with severe migraine headache, administration of intravenous valproic acid seems to be safe and rapidly effective at alleviating symptoms. [26]
6. A study found that valproic acid treats migraine by increasing brain GABA levels. [27]
7. In adult patients with episodic migraine, valproic acid reduced headache frequency and was reasonably well tolerated. [28]
8. In patients with refractory migraine, a type of migraine not relieved or prevented by acute migraine therapies, valproic acid administration at a dose of 1,250 mg daily reduced headache severity. [29]
9. In migraine sufferers, valproic acid administration at a dose of 100–600 mg/day was consistent in alleviating symptoms. [30]
10. Administration of 400 mg valproic acid twice daily for 8 weeks in patients with migraine was effective in reducing the frequency, severity and duration of the attacks. [31]
11. Administration of 70 to 120 mg/L of valproic acid in patients with migraine headaches was associated with significantly lesser functional restriction and symptoms. [32]
12. Valproic acid appeared to be equivalent in efficacy and safety to topiramate, an anti-epileptic drug, in reducing the duration, monthly frequency, and intensity of headache. [33]

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