Treating seizures is the earliest and most prominent use of this anticonvulsant medication, and it is still prescribed for this condition today. Numerous clinical trials support the safety and efficacy of valproic acid in reducing the prevalence of seizure attacks:
1. In epileptic children, valproic acid exhibited similar effectiveness to ethosuximide, the current gold standard for treating epileptic seizures.
2. In patients with glioblastoma multiforme, a deadly brain cancer, valproic acid administration reduced seizure attacks and resulted in a 2-month longer survival.
3. In late-onset post-stroke epilepsy patients, valproic acid administration was associated with better seizure control.
4. In patients with chronic seizure, valproic acid was found to be effective at reducing the incidence of attacks.
5. In patients with idiopathic generalized epilepsies, valproic acid provided superior control of epileptic seizures and was associated with fewer hospitalizations and emergency department visits.
6. In patients with hemorrhagic stroke (caused by blood vessel rupture), valproic acid reduced the occurrence of seizures in the early period.
7. In patients with uncontrolled seizures of a generalized or partial type, valproic acid administration was associated with significant reduction in seizure frequency ranging from 25 to 100%.
8. In patients with poorly controlled complex partial seizures, valproic acid treatment significantly reduced seizure by 50%.
9. Valproic acid was found to be similar in efficacy with other antiepileptic drugs such as carbamazepine, phenytoin, phenobarbital, and ethosuximide in the treatment of generalized, partial, and absence seizures.[9-10]
10. In patients with juvenile myoclonic epilepsy, valproic acid significantly reduced the incidence of seizure attacks.
11. In patients with generalized tonic-clonic seizures, valproic acid administration alone demonstrated greater efficacy at reducing attacks.
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