Vitamin D and Kidney Health

There is a fascinating relationship between vitamin D and the kidneys. Whether from supplements or from the sun, the kidneys help convert vitamin D into its active form so that it can be effectively used by the body. Newer research shows that vitamin D may play a protective role against kidney disorders and keeping the kidneys working at optimum levels:
1. Patients with chronic kidney disease (CKD) have abnormally low levels of vitamin D, suggesting that vitamin D replacement therapy may have benefical effect. [805-812]
2. In patients with CKD, vitamin D replacement therapy prevents complications by decreasing excess levels of parathyroid hormone (causes cardiovascular and bone complications). [813-824]
3. In patients with CKD who are on dialysis, vitamin D therapy improves survival rate. [825-836]
4. In animal models of glomerulonephritis (acute inflammation of the kidney), vitamin D therapy slows the progression of kidney disease. [837-843]
5. In patients with CKD, supplementation with vitamin D is recommended at the early stage of the disease. [844]
6. In patients with CKD and those undergoing hemodialysis, activated vitamin D treatment reduces all-cause and cardiovascular mortality rates. [845-848]
7. In patients with CKD, vitamin D supplementation improves glomerular filtration rate, a measure of kidney function. [849-850]
8. In patients on dialysis, vitamin D supplementation lowers the rate of kidney complications by preventing calcium build-up in the blood vessels. [851-860]
9. In patients with CKD, vitamin D supplementation prevents the leakage of protein into the urine. [861-863]
10. In animal models, vitamin D prevents kidney enlargement and scarring. [864-867]
11. In hemodialysis patients, vitamin D supplementation improves kidney function by reducing the levels of proinflammatory cytokines, IL-8, IL-6, and TNF. [868]
12. In patients with CKD, vitamin D supplementation improves blood flow to the kidney. [869]

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