Naltrexone is a drug used to treat alcoholism and opioid addiction. It belongs to a group of drugs called opioid antagonists, which work by blocking the effect of opioid receptors and dramatically reducing cravings and urges to drink alcohol or take opioids. Along with counseling and other support, naltrexone treatment allows patients to maintain abstinence, reduce the harms related to the use of these substances, and improve their quality of life. Naltrexone is taken in the form of tablets, injections, or implants. The length of the treatment greatly depends on each patient’s needs and situation.

Overall Health Benefits of Naltrexone

  • Treats alcohol dependence [1-34]
  • Treats opioid addiction [35-46]
  • Reduces insulin resistance [47-52]
  • Boosts growth hormone levels [51] [53]
  • Promotes weight loss [54-57]
  • Fights inflammation [58-72]
  • Improves sleep and sleeping pattern [73-76]
  • Improves thyroid function [77-78]

Proven Health Benefits of Naltrexone

Treats Alcohol Dependence

Treating alcohol dependence is one the main benefits of naltrexone. An overwhelming body of clinical evidence clearly supports its effects on alcohol cravings:

  1. In women with alcohol use disorders, naltrexone treatment reduced drinking quantity and time to relapse. [1]
  2. In patients with alcohol dependence and at least 4 days of abstinence, naltrexone administration at a dose of 100 mg daily for 16 weeks significantly increased days of abstinence and reduced the risk of heavy-drinking days. [2]
  3. In male alcohol-dependent patients, naltrexone treatment for 12 weeks prevented alcohol relapse without any adverse side effects. [3]
  4. An analysis of several studies found that 19 (70%) of 27 clinical trials assessing the effect of naltrexone on alcohol addiction showed significant reductions in “heavy or excessive drinking”. [4]
  5. An analysis of several studies also found that naltrexone treatment was associated with reductions in event-level craving and consumption. [5]
  6. In alcohol-dependent men, naltrexone promoted abstinence and decreased the incidence of relapse. [6]
  7. In patients with alcohol dependence, naltrexone treatment resulted in a significant reduction in heavy drinking. [7]
  8. In alcohol-dependent participants who were highly compliant with taking naltrexone, the treatment significantly improved outcome measures. [8]
  9. An analysis of multiple studies also found that naltrexone reduced relapse rates after abstinence. [9]
  10. In alcohol-dependent men, naltrexone reduced the consumption of alcohol and was well-tolerated. [10]
  11. An analysis of several studies assessing the effects of naltrexone on alcohol dependence found that short-term administration of the drug reduced the relapse rate significantly. [11]
  12. When administered to patients who were still currently drinking, naltrexone safely and effectively reduced cravings. [12-13]
  13. In alcoholic men, naltrexone treatment significantly reduced alcohol craving and drinking, and was associated with lesser euphoria related to alcohol consumption. [14]
  14. In alcoholic patients, naltrexone significantly improved treatment compliance and reduced cravings. [15]
  15. When combined with gabapentin, a drug for nerve pain, naltrexone improved drinking outcomes. [16]
  16. Naltrexone has also been found to be effective when administered without a period of abstinence or detoxification in alcoholics. [17]
  17. Recent studies found that naltrexone treatment was beneficial in alcoholic patients when given during a period of abstinence. [18-19]
  18. Oral naltrexone has a moderate to good clinical efficacy in treating patients with alcohol dependence. [20]
  19. Studies also found that naltrexone is most effective for achieving controlled drinking. [21-22]
  20. A study found that the effectiveness of naltrexone treatment is greater during active alcohol consumption [23].
  21. Naltrexone is also associated with significant improvements in several clinical measures such as time to alcohol relapse, daily alcohol intake, liver function indicators, and reduction in alcohol craving. [24]
  22. Studies found that administration of depot sustained release formulations of naltrexone for 4 weeks is highly associated with improved treatment outcomes. [25-28]
  23. Studies also found that naltrexone injection at a dose of 380 mg reduced the number of heavy drinking days per month by 10 times. [29-30]
  24. Several studies also reported that treatment with a longer acting naltrexone preparation can significantly reduce the frequency of re-treatments and relapse and can produce stable patient outcomes over time. [31-34]

Treats Opioid Addiction

Illegal use of opioids such as heroin, fentanyl, and morphine can lead to addiction and impaired quality of life. Several lines of evidence suggest that naltrexone can treat addiction to opioids by blocking certain signals in the brain:

  1. In opioid-addicted patients recently undergoing detoxification, naltrexone implant is more effective than oral naltrexone treatment at preventing relapse. [35-36]
  2. Studies found that one 50-mg tablet blocks μ-opioid receptors for 24 to 36 hours, preventing relapse and symptoms of withdrawal. [37-38]
  3. A study found that sustained-release injected naltrexone in patients with opioid dependence is associated with significantly better outcomes. [39]
  4. When combined with counseling and other behavioral therapies, naltrexone appears to produce significant clinical improvements in patients with opioid use disorder. [40-43]
  5. A study found that long-acting, sustained-release naltrexone formulations (both injectable and implantable) appears to be more effective than oral formulations. [44]
  6. In women with opioid addiction, the combination of naltrexone and fluoxetine appears to be more effective compared with monotherapy. [45]
  7. In patients undergoing opioid detoxification, low-dose naltrexone therapy improved subjective opioid withdrawal scores (SOWS). [46]

Reduces Insulin Resistance

Insulin resistance is a condition in which the cells of the body do not respond properly to the effects of the hormone insulin. As a result, blood sugar levels become elevated. Chronic elevation in blood sugar can be life-threatening as it can lead to nerve damage, vision problems, and impaired kidney function. Interestingly, studies have shown that naltrexone can help improve insulin resistance and normalize blood sugar levels:

  1. In obese individuals, naltrexone therapy reduced hemoglobin A1c (HbA1c), a measure of blood sugar level. [47]
  2. In obese women with polycystic ovary syndrome (PCOS), naltrexone improved insulin resistance after 3 and 6 months of treatment. [48]
  3. Naltrexone also improved fasting serum insulin in women with PCOS, suggesting that the hormone is effectively utilized by their bodies. [49]
  4. In diabetic women with severe and chronic eating disorders, naltrexone improved blood sugar control. [50]
  5. In normal obese patients, long-term naltrexone treatment reduced fasting insulin levels. [51]
  6. In women with insulin resistance related to elevated male sex hormones, long-term treatment with naltrexone dramatically reduced blood sugar levels. [52]

Boosts Growth Hormone Levels

Research has shown that naltrexone has the ability to boost growth hormone (GH) levels. This is a significant finding since GH plays an integral role in building and maintaining lean muscle mass, reducing body fat, speeding up metabolism, and other important functions.

  1. In obese patients, 4 weeks of treatment with naltrexone at 50 mg/day increased blood concentrations of GH. [51]
  2. In obese women, naltrexone augmented the production of GH. [53]

Promotes Weight Loss

Naltrexone can also help achieve healthier weight, thus, reducing one’s risk for obesity-related diseases. Studies show that this drug works by reducing food intake:

  1. In obese men, increasing doses of naltrexone (25 to 200 mg) given over 4 consecutive days reduced food intake by 30%. [54]
  2. Long-term therapy with naltrexone (8 weeks) reduced body weight of obese women by an average of 1.7 kg. [55]
  3. Administration of naltrexone alone in obese patients significantly reduced body weight. [56]
  4. In patients with damaged metabolism, naltrexone treatment resulted in restoration of energy expenditure. [57]

Fights Inflammation

Studies show that naltrexone can help ward off various inflammatory conditions because of its potent anti-inflammatory properties:

  1. Studies have shown that naltrexone may help reduce inflammation by lowering the levels of inflammatory cytokines. [58-60]
  2. Studies found that low-dose naltrexone is safe and effective in the treatment of chronic inflammatory skin conditions. [61-63]
  3. In patients with chronic inflammatory bowel disease, naltrexone induced clinical improvement and prevented remission. [64-66]
  4. In patients with rheumatoid arthritis, naltrexone treatment significantly improved symptoms and reduced the use of pain relievers. [67]
  5. Studies also show that naltrexone may help improve symptoms in autoimmune inflammatory conditions such as fibromyalgia. [68-72]

Improves Sleep and Sleeping Pattern

There’s also a great deal of evidence supporting the benefits of naltrexone on sleep quantity and quality:

  1. In patients with sleep apnea, naltrexone has been shown to improve symptoms and sleeping patterns. [73-74]
  2. In patients with complex regional pain syndrome and other chronic pain syndromes, naltrexone treatment improved sleep quality. [75]
  3. In healthy male volunteers, naltrexone improved various sleep parameters. [76]

Improves Thyroid Function

Taking naltrexone also has benefits on thyroid health. Studies show that this drug can help improve thyroid function:

  1. In patients with hypothyroidism and Hashimoto’s thyroiditis, naltrexone improved T4 to T3 conversion and reduced inflammation. [77]
  2. In patients with chronic fatigue syndrome (CFS), naltrexone normalized the levels of thyroid hormones. [78]


  1. Canidate SS, Carnaby GD, Cook CL, Cook RL. A Systematic Review of Naltrexone for Attenuating Alcohol Consumption in Women with Alcohol Use Disorders. Alcohol Clin Exp Res. 2017;41(3):466–472. doi:10.1111/acer.13313.
  2. Anton RF. Naltrexone for the management of alcohol dependence. N Engl J Med. 2008;359(7):715–721. doi:10.1056/NEJMct0801733.
  3. Volpicelli JR, Alterman AI, Hayashida M, O’brien CP. Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry. 1992;49(11):876-80.
  4. Pettinati HM, O’brien CP, Rabinowitz AR, et al. The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking. J Clin Psychopharmacol. 2006;26(6):610-25.
  5. Hendershot CS, Wardell JD, Samokhvalov AV, Rehm J. Effects of naltrexone on alcohol self-administration and craving: meta-analysis of human laboratory studies. Addict Biol. 2017;22(6):1515-1527.
  6. Johnson BA. Naltrexone long-acting formulation in the treatment of alcohol dependence. Ther Clin Risk Manag. 2007;3(5):741–749.
  7. Oslin DW, Leong SH, Lynch KG, et al. Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial. JAMA Psychiatry. 2015;72(5):430-7.
  8. Volpicelli JR, Rhines KC, Rhines JS, Volpicelli LA, Alterman AI, O’brien CP. Naltrexone and alcohol dependence. Role of subject compliance. Arch Gen Psychiatry. 1997;54(8):737-42.
  9. Pettinati HM, O’Brien CP, Rabinowitz AR, Wortman SP, Oslin DW, Kampman KM, et al. The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking. J Clin Psychopharmacol 2006;26:610-25.
  10. Morris PL, Hopwood M, Whelan G, Gardiner J, Drummond E. Naltrexone for alcohol dependence: a randomized controlled trial. Addiction. 2001;96(11):1565-73.
  11. Bouza C, Angeles M, Magro A, Muñoz A, Amate JM. Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction. 2004;99(7):811-28.
  12. Sinclair JD. Evidence about the use of naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol Alcohol. 2001;36(1):2-10.
  13. Kruse MI, Radnovich AJ, Kalapatapu RK, Mehdiyoun N, Chambers RA, Davidson D. Effects of alcohol availability, access to alcohol, and naltrexone on self-reported craving and patterns of drinking in response to an alcohol-cue availability procedure. J Stud Alcohol Drugs. 2012;73(2):205-15.
  14. O’brien CP, Volpicelli LA, Volpicelli JR. Naltrexone in the treatment of alcoholism: a clinical review. Alcohol. 1996;13(1):35-9.
  15. Lobmaier PP, Kunøe N, Gossop M, Waal H. Naltrexone depot formulations for opioid and alcohol dependence: a systematic review. CNS Neurosci Ther. 2011;17(6):629-36.
  16. Anton RF, Myrick H, Wright TM, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011;168(7):709-17.
  17. Heinala P, Alho H, Kiianmaa K, Lonnqvist J, Kuoppasalmi K, Sinclair JD. Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: a factorial double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2001;21:287–92.
  18. O’Malley SS, Sinha R, Grilo CM, Capone C, Farren CK, McKee SA, et al. Naltrexone and cognitive behavioral coping skills therapy for the treatment of alcohol drinking and eating disorder features in alcohol-dependent women: a randomized controlled trial. Alcohol Clin Exp Res. 2007;31:625–34.
  19. Garbutt JC, Kranzler HR, O’Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, et al. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA. 2005;293:1617–25.
  20. Latt NC, Jurd S, Houseman J, Wutzke SE. Naltrexone in alcohol dependence: a randomised controlled trial of effectiveness in a standard clinical setting. Med J Aust. 2002;176:530–534.
  21. Garbutt JC. Efficacy and tolerability of naltrexone in the management of alcohol dependence. Curr Pharm Des. 2010;16:2091–2097.
  22. Kranzler HR, Van Kirk J. Efficacy of Naltrexone and Acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res. 2001;25:1335–1341.
  23. Mitchell JM, Bergren LJ, Chen KS, Rowbotham MC, Fields HL. Naltrexone aversion and treatment efficacy are greatest in humans and rats that actively consume high levels of alcohol. Neurobiol Dis. 2009;33:72–80.
  24. Carmen B, Angeles M, Ana M, Maria AJ. Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction. 2004;99:811–828.
  25. Galloway GP, Koch M, Cello R, Smith DE. Pharmacokinetics, safety, and tolerability of a depot formulation of naltrexone in alcoholics: an open-label trial. BMC Psychiatry. 2005;5:18.
  26. Garbutt JC, Kranzler HR, O’Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, Loewy JW, Ehrich EW Vivitrex Study Group. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA. 2005;293:1617–1625.
  27. Kranzler HR, Wesson DR, Billot L. Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial. Alcohol Clin Exp Res. 2004;28:1051–1059.
  28. Kranzler HR, Modesto-Lowe V, Nuwayser ES. Sustained-release naltrexone for alcoholism treatment: a preliminary study. Alcohol Clin Exp Res. 1998;22:1074–1079.
  29. O’Malley SS, Garbutt JC, Gastfriend DR, Dong Q, Kranzler HR. Efficacy of extended-release aaltrexone in alcohol-dependent patients who are abstinent before treatment. J Clin Psychopharmacol. 2007;27:507–512.
  30. Ciraulo DA, Dong Q, Silverman BL, Gastfriend DR, Pettinati HM. Early treatment response in alcohol dependence with extended-release naltrexone. J Clin Psychiatry. 2008;69:190–195.
  31. Garbutt JC, Kranzler HR, O’Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, Loewy JW, Ehrich EW Vivitrex Study Group. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. JAMA. 2005;293:1617–1625.
  32. Kranzler HR, Wesson DR, Billot L. Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial. Alcohol Clin Exp Res. 2004;28:1051–1059.
  33. Kranzler HR, Modesto-Lowe V, Nuwayser ES. Sustained-release naltrexone for alcoholism treatment: a preliminary study. Alcohol Clin Exp Res. 1998;22:1074–1079.
  34. Johnson BA, Ait-Daoud N, Aubin H-J, van den Brink W, Guzzetta R, Loewy J. A pilot evaluation of the safety and tolerability of repeat dose administration of long-acting injectable naltrexone (Vivitrex (R)) in patients with alcohol dependence. Alcohol Clin Exp Res. 2004;28:1356–1361.
  35. Krupitsky E, Zvartau E, Blokhina E, et al. Randomized trial of long-acting sustained-release naltrexone implant vs oral naltrexone or placebo for preventing relapse to opioid dependence. Arch Gen Psychiatry. 2012;69(9):973–981. doi:10.1001/archgenpsychiatry.2012.1a.
  36. Kunoe N, Lobmaier P, Vederhus JK, Hjerkinn B, Hegstad S, Gossop M, Kristensen Ø, Waal H. Naltrexone implants after in-patient treatment for opioid dependence: randomised controlled trial. Br J Psychiatry. 2009;194(6):541–546.
  37. Kleber HD, Kosten TR, Gaspari J, Topazian M. Nontolerance to the opioid antagonism of naltrexone. Biol Psychiatry. 1985;20(1):66–72.
  38. Kleber HD. Pharmacologic treatments for opioid dependence: detoxification and maintenance options. Dialogues Clin Neurosci. 2007;9(4):455–470.
  39. Krupitsky E, Nunes EV, Ling W, Illeperuma A, Gastfriend DR, Silverman BL. Injectable extended-release naltrexone for opioid dependence: a double-blind, placebo-controlled, multicentre randomised trial. Lancet. 2011;377(9776):1506–1513.
  40. FDA News Release, “FDA approves first buprenorphine implant for treatment of opioid dependence,”
  41. Preston KL, Silverman K, Umbricht A, et al. Improvement in naltrexone treatment compliance with contingency management. Drug Alcohol Depend. 1999;54:127–135.
  42. Carroll KM, Ball SA, Nich C, et al. Targeting behavioral therapies to enhance naltrexone treatment of opioid dependence: efficacy of contingency management and significant other involvement. Arch Gen Psychiatry. 2001;58:755–761.
  43. Rounsaville B. Can psychotherapy rescue naltrexone treatment of opioid addiction? In: Onken L, Blaine J, editors. Potentiating the Efficacy of Medications: Integrating Psychosocial Therapies With Pharmacotherapies in the Treatment of Drug Dependence. Rockville, MD: National Institute on Drug Abuse; 1995. pp. 37–52. NIDA Research Monograph series no. 105, NIH publication no. 95-3899.
  44. Krupitsky E, Zvartau E, Woody G. Use of naltrexone to treat opioid addiction in a country in which methadone and buprenorphine are not available. Curr Psychiatry Rep. 2010;12(5):448–453. doi:10.1007/s11920-010-0135-5.
  45. Krupitsky EM, Zvartau EE, Masalov DV, et al. Naltrexone with or without fluoxetine for preventing relapse to heroin addiction in St. Petersburg, Russia. J Subst Abuse Treat. 2006;31:319–328.
  46. Mannelli P, Patkar AA, Peindl K, Gottheil E, Wu LT, Gorelick DA. Early outcomes following low dose naltrexone enhancement of opioid detoxification. Am J Addict. 2009;18(2):109–116. doi:10.1080/10550490902772785.
  47. Wilding JPH. Medication use for the treatment of diabetes in obese individuals. Diabetologia. 2018;61(2):265–272. doi:10.1007/s00125-017-4288-1 Wilding JPH. Medication use for the treatment of diabetes in obese individuals. Diabetologia. 2018;61(2):265–272. doi:10.1007/s00125-017-4288-1.
  48. Fruzzetti F, Bersi C, Parrini D, Ricci C, Genazzani AR. Effect of long-term naltrexone treatment on endocrine profile, clinical features, and insulin sensitivity in obese women with polycystic ovary syndrome. Fertil Steril. 2002;77(5):936-44.
  49. Ahmed MI, Duleba AJ, El shahat O, Ibrahim ME, Salem A. Naltrexone treatment in clomiphene resistant women with polycystic ovary syndrome. Hum Reprod. 2008;23(11):2564-9.
  50. Raingeard I, Courtet P, Renard E, Bringer J. Naltrexone improves blood glucose control in type 1 diabetic women with severe and chronic eating disorders. Diabetes Care. 2004;27(3):847-8.
  51. Villa P, Fulghesu AM, De marinis L, et al. Impact of long-term naltrexone treatment on growth hormone and insulin secretion in hyperandrogenic and normal obese patients. Metab Clin Exp. 1997;46(5):538-43.
  52. Sir-petermann T, López G, Castillo T, Calvillán M, Rabenbauer B, Wildt L. Naltrexone effects on insulin sensitivity and insulin secretion in hyperandrogenic women. Exp Clin Endocrinol Diabetes. 1998;106(5):389-94.
  53. De marinis L, Mancini A, Valle D, et al. Influence of chronic Naltrexone treatment on growth hormone and insulin secretion in obese subjects. Int J Obes Relat Metab Disord. 1997;21(11):1076-81.
  54. Spiegel TA, Stunkard AJ, Shrager EE, O’brien CP, Morrison MF, Stellar E. Effect of naltrexone on food intake, hunger, and satiety in obese men. Physiol Behav. 1987;40(2):135-41.
  55. Atkinson RL, Berke LK, Drake CR, Bibbs ML, Williams FL, Kaiser DL. Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther. 1985;38(4):419-22.
  56. Lee MW, Fujioka K. Naltrexone for the treatment of obesity: review and update. Expert Opin Pharmacother. 2009;10(11):1841-5.
  57. Yeomans, M. R., & Gray, R. W. (1997). Effects of Naltrexone on Food Intake and Changes in Subjective Appetite During Eating: Evidence for Opioid Involvement in the Appetizer Effect.Physiology & Behavior,62(1), 15-21. doi:10.1016/s0031-9384(97)00101-7.
  58. Parkitny L., Younger J. Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia. Biomedicines. 2017;5:16. doi: 10.3390/biomedicines5020016.
  59. Tawfik D.I., Osman A.S., Tolba H.M., Khattab A., Abdel-Salam L.O., Kamel M.M. Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn’s disease in rats. Neuropeptides. 2016;59:39–45. doi: 10.1016/j.npep.2016.06.003.
  60. Matters G.L., Harms J.F., McGovern C., Fitzpatrick L., Parikh A., Nilo N., Smith J.P. The opioid antagonist naltrexone improves murine inflammatory bowel disease. J. Immunotoxicol. 2008;5:179–187. doi: 10.1080/15476910802131469.
  61. Ekelem C, Juhasz M, Khera P, Mesinkovska NA. Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review. JAMA Dermatol. 2019;155(2):229-236.
  62. Lee B, Elston DM. The uses of naltrexone in dermatologic conditions. J Am Acad Dermatol. 2019;80(6):1746-1752.
  63. Strazzulla LC, Avila L, Lo sicco K, Shapiro J. Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris. J Drugs Dermatol. 2017;16(11):1140-1142.
  64. Smith JP, Stock H, Bingaman S, Mauger D, Rogosnitzky M, Zagon IS. Low-dose naltrexone therapy improves active Crohn’s disease. Am J Gastroenterol. 2007;102(4):820-8.
  65. Lie MRKL, Van der giessen J, Fuhler GM, et al. Low dose Naltrexone for induction of remission in inflammatory bowel disease patients. J Transl Med. 2018;16(1):55.
  66. Raknes G, Simonsen P, Småbrekke L. The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2018;12(6):677-686.
  67. Raknes G, Småbrekke L. Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study. PLoS ONE. 2019;14(2):e0212460.
  68. Metyas S, Chen CL, Yeter K, Solyman J, Arkfeld DG. Low Dose Naltrexone in the Treatment of Fibromyalgia. Curr Rheumatol Rev. 2018;14(2):177-180.
  69. Younger J, Noor N, Mccue R, Mackey S. Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis Rheum. 2013;65(2):529-38.
  70. Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009;10(4):663-72.
  71. Younger J, Mackey S. Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study. Pain Med. 2009;10(4):663–672. doi:10.1111/j.1526-4637.2009.00613.x.
  72. Trofimovitch D, Baumrucker SJ. Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes. Am J Hosp Palliat Care. 2019;36(10):907-912.
  73. Yim, S., Jordan, A., & Malhotra, A. (2006). Obstructive Sleep Apnea: Clinical Presentation, Diagnosis and Treatment.Sleep Apnea Progress in Respiratory Research,118-136. doi:10.1159/000093154.
  74. Ferber C, Sanchez P, Lemoine P, Mouret J. [Efficacy of the treatment of sleep apnea using naltrexone. A clinical, polygraphic and gasometric study]. C R Acad Sci III, Sci Vie. 1988;307(12):695-700.
  75. Chopra, P., & Cooper, M. S. (2013). Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN).Journal of Neuroimmune Pharmacology,8(3), 470-476. doi:10.1007/s11481-013-9451-y.
  76. Sramek J, Andry JM, Ding H, Riordan HJ, Leibowitz M, Cutler NR. The effect of naltrexone on sleep parameters in healthy male volunteers. J Clin Psychopharmacol. 2014;34(1):167-8.
  77. Ilias, I., Kakoulas, I., Christakopoulou, I., & Katsadoros, K. (2001). Thyroid Function of Former Opioid Addicts on Naltrexone Treatment.Acta Medica (Hradec Kralove, Czech Republic),44(1), 33-35. doi:10.14712/18059694.2019.84.
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