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Noopept

Noopept is a powerful nootropic (cognitive enhancer) that is a thousand times more potent and stronger than piracetam. Unlike other nootropics, the effect of this synthetic smart drug can be felt in just a few minutes after it reaches the bloodstream. To reap the full benefits of Noopept, it can be taken in pill, powder or drop form and is available in many drugstores.

Overall Health Benefits of Noopept

  • Improves memory and cognition by promoting growth of brain cells. [1-18]
  • Fights anxiety [2, 19-20]
  • Boosts immune function [21-23]
  • Improves mood [24-26]

Proven Health Benefits of Noopept

Improves Cognitive Function

An overwhelming body of clinical evidence supports the benefits of Noopept on various areas of cognitive function such as memory, learning, and thinking ability:

  • In patients with cognitive disturbances caused by traumas or vascular brain diseases, Noopept improved brain function as evidenced by increased alpha- and beta-rhythms power in the electroencephalogram (EEG). [1-2]
  • Administration of Noopept at a dose of 20 mg daily for 2 months improved cognitive function in patients with stroke and has a high level of safety. [3]
  • In several animal models of Alzheimer disease (AD), Noopept protected rat brain cells against amyloid beta toxicity (causative agent of AD) by inhibiting oxidative damage, preventing calcium overload, and suppressing apoptosis (programed cell death). [4-10]
  • Repeated oral administration of Noopept in rats improved learning compared to single dose. [11]
  • In a photochemical stroke rat model, Noopept demonstrated both cognition-restoring and neuroprotective properties. [12]
  • In normal and Down’s syndrome human brain neurons, Noopept prevented oxidative damage and apoptosis. [13]
  • In conscious rats, Noopept administration increased brain activity in the EEG. [14]
  • Noopept has the ability to increase the levels of Nerve Growth Factor and Brain Derived Neurotrophic Factor, which is associated with chronic improvement in memory. [15-16]
  • Noopept may help improve cognitive function by enhancing the electrical signals between neurons. [17]
  • Noopept at a 1:1 ratio or ten-fold greater appeared to significantly reduce the levels of Lewy bodies (protein clumps causing Parkinson’s disease) in the brain. [18]

Fights Anxiety

Noopept’s cognitive-enhancing abilities also produce anti-anxiety effect according to studies:

  • In rats, Noopept administration was associated with an increase in locomotor activity in the elevated plus-maze test, suggesting an anti-anxiety effect. [19]
  • Noopept administration also increased exploratory behavior of rats undergoing open field test, which is indicative of reduced anxiety. [20]
  • Administration of Noopept in patients with mild cognitive impairment reduced fatigue, anxiety, and irritability. [2]

Boosts Immune Function

Taking Noopept can also ward off a wide array of diseases. There is increasing evidence suggesting that this cognitive enhancer also has potent immune-boosting properties:

  • In animal models, Noopept stimulated humoral and cellular immune response to various antigens (harmful microorganisms) and markedly increased the levels of white blood cells. [21]
  • In rats, Noopept administration for 5 days at a daily dose of 0.5 mg/kg (injections) or 5 mg/kg (oral) significantly reduced chronic immune inflammation. [22]
  • In mice, Noopept injection at 5 mg/kg reduced the levels of inflammatory substances such as IL-6 and TNF-alpha. [23]

Improves Mood

Noopept can also help improve mood, making it a potential therapeutic option for certain mental health disorders:

  • In rats with neurosis, a mental illness characterized by stress, depression, anxiety, and obsessive behavior, Noopept administration reduced the incidence of learned helplessness. [24]
  • Long-term Noopept administration (21 days) significantly eliminated the manifestations of learned helplessness compared to the anti-anxiety drug Afobazol. [25]
  • Chronic administration (28 days, 0.5 mg/day via injections) of Noopept improved behavior by decreasing the activity of stress-induced kinases (involved in mental disorders) and increasing the levels of BDNF. [26]

References:

  1. Bochkarev VK, Teleshova ES, Siuniakov SA, Davydova DV, Neznamov GG. [Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(11):47-54.
  2. Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neurosci Behav Physiol. 2009;39(3):311-21.
  3. Amelin AV, Iliukhina AIu, Shmonin AA. [Noopept in the treatment of mild cognitive impairment in patients with stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(10 Pt 1):44-6.
  4. Ostrovskaya RU, Vakhitova YV, Kuzmina USh, et al. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014;21:74.
  5. Jia X, Gharibyan AL, Öhman A, Liu Y, Olofsson A, Morozova-roche LA. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. J Mol Biol. 2011;414(5):699-712.
  6. Ostrovskaya RU, Gruden MA, Bobkova NA, et al. The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model. J Psychopharmacol (Oxford). 2007;21(6):611-9.
  7. Ostrovskaia RU, Tsaplina AP, Vakhitova IuV, Salimgareeva MKh, Iamidanov RS. [Effect of the novel nootropic and neuroprotective dipeptide noopept on the streptozotocin-induced model of sporadic Alzheimer disease in rats]. Eksp Klin Farmakol. 2010;73(1):2-6.
  8. Ostrovskaya RU, Vakhitova YV, Kuzmina USh, et al. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci. 2014;21:74.
  9. Ostrovskaya RU, Belnik AP, Storozheva ZI. Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats). Bull Exp Biol Med. 2008;146(1):77-80.
  10. Bobkova NV, Gruden’ MA, Samokhin AN, et al. [Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice]. Eksp Klin Farmakol. 2005;68(5):11-5.
  11. Ostrovskaya RU, Mirsoev TK, Romanova GA, et al. Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration. Bull Exp Biol Med. 2001;132(4):959-62.
  12. Ostrovskaya RU, Romanova GA, Barskov IV, et al. Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model. Behav Pharmacol. 1999;10(5):549-53.
  13. Pelsman A, Hoyo-vadillo C, Gudasheva TA, Seredenin SB, Ostrovskaya RU, Busciglio J. GVS-111 prevents oxidative damage and apoptosis in normal and Down’s syndrome human cortical neurons. Int J Dev Neurosci. 2003;21(3):117-24.
  14. Vorobyov V, Kaptsov V, Kovalev G, Sengpiel F. Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors. Brain Res Bull. 2011;85(3-4):123-32.
  15. Radionova KS, Belnik AP, Ostrovskaya RU. Original nootropic drug noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade. Bull Exp Biol Med. 2008;146(1):59-62.
  16. Ostrovskaya RU, Gudasheva TA, Zaplina AP, et al. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. 2008;146(3):334-7.
  17. Lutsenko VK, Vukolova MN, Gudasheva TA. Cyclopropyl glycine and proline-containing preparation noopept evoke two types of membrane potential responses in synaptoneurosomes. Bull Exp Biol Med. 2003;135(6):559-62.
  18. Jia X, Gharibyan AL, Öhman A, Liu Y, Olofsson A, Morozova-roche LA. Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity. J Mol Biol. 2011;414(5):699-712.
  19. Gudasheva TA, Konstantinopol’skii MA, Ostrovskaya RU, Seredenin SB. Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test. Bull Exp Biol Med. 2001;131(5):464-6.
  20. Voronina TA, Guzevatykh LS, Trofimov SS. [Comparative study of the long-term behavioral effects of noopept and piracetam in adult male rats and female rats in postnatal period]. Eksp Klin Farmakol. 2005;68(2):3-7.
  21. Kovalenko LP, Shipaeva EV, Alekseeva SV, et al. Immunopharmacological properties of noopept. Bull Exp Biol Med. 2007;144(1):49-52.
  22. Kovalenko LP, Miramedova MG, Alekseeva SV, Gudasheva TA, Ostrovskaia RU, Seredenin SB. [Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]. Eksp Klin Farmakol. 2002;65(2):53-5.
  23. Alekseeva SV, Kovalenko LP, Tallerova AV, Gudasheva TA, Durnev AD. [An experimental study of the anti-inflammatory action of noopept and its effect on the level of cytokines]. Eksp Klin Farmakol. 2012;75(9):25-7.
  24. Uyanaev AA, Fisenko VP, Khitrov NK. Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats. Bull Exp Biol Med. 2003;136(2):162-4.
  25. Uyanaev AA, Fisenko VP. Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. Bull Exp Biol Med. 2006;142(2):202-4.
  26. Ostrovskaia RU, Vakhitova IuV, Salimgareeva MKh, et al. [On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines]. Eksp Klin Farmakol. 2010;73(12):2-5.
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