Pygeum africanum Bark Powder

Pygeum africanum Bark Powder

Pygeum or Prunus africanum, also known as African cherry, is a tree that is native to central and southern regions of Africa. Its bark is commonly used to treat a broad range of medical maladies including enlarged prostate, certain types of cancer, kidney disease, urinary problems, sexual dysfunction, infection, and other inflammatory conditions.

Overall Health Benefits of Pygeum africanum Bark Powder

  • Improves symptoms of diabetes and blood sugar levels [1]
  • Improves prostate health [2-6]
  • Combats cancer [7-11]
  • Treats symptoms of kidney disease [12-13]
  • Relieves pain [14-15]

How Pygeum africanum Bark Powder Works

Pygeum africanum bark is a natural herbal supplement that contains triterpenes, ferulic acid, and phytosterols. Triterpenes block enzymes that are responsible for the destruction of connective tissues, which could lead to possible improvement of symptoms of an enlarged prostate. Ferulic acid is a plant-based antioxidant with strong anti-inflammatory properties while phytosterols can help block pain sensation via inhibition of prostaglandin synthesis.

Proven Health Benefits of Pygeum africanum Bark Powder

Improves Symptoms of Diabetes and Blood Sugar Levels

Studies show that Pygeum africanum bark has potent antidiabetic properties:

  1. In adult Wistar male rats, treatment with Pygeum africanum bark suppressed the oxidative stress status in diabetic bladder. [1]

Improves Prostate Health

Evidence suggests that Pygeum africanum bark can benefit prostate health by protecting against various prostate conditions:

  1. A study found that pygeum africanum bark extract administration improved all the urinary parameters and relieved prostate inflammation. [2]
  2. A study found that pygeum africanum bark may be a useful treatment option for men with lower urinary tract symptoms consistent with benign prostatic hyperplasia (BPH) or prostate enlargement. [3]
  3. A cell study found that pygeum africanum bark can help prevent BPH by slowing the growth of actual prostate cells. [4]
  4. In cultured human prostate cells, treatment with pygeum africanum bark inhibited the growth and multiplication of the cells. [5]
  5. In older men with BPH, pygeum africanum bark prevented prostate cell growth by inhibiting basic fibroblast growth factor (bFGF). [6]

Combats Cancer

There’s increasing evidence supporting the anti-cancer properties of pygeum africanum bark:

  1. A study found that pygeum africanum bark extract has the ability to kill tumor cells by suppressing the growth of new blood vessels. [7]
  2. A cell study found that pygeum africanum bark has a significant role in the suppression prostate cancer. [8]
  3. In human prostatic cancer cell lines, pygeum africanum bark inhibited mitosis (cell division). [9]
  4. In cultured prostate stromal cells from patients with BPH, pygeum africanum bark induced programmed cell death (apoptosis) of cells. [10]
  5. In adult Sprague-Dawley male rats, pygeum africanum bark prevented the increase in prostatic weight. [11]

Treats Symptoms of Kidney Disease

A growing body of clinical evidence suggests that pygeum africanum bark can be used as a therapeutic option in kidney disease:

  1. A study found that pygeum africanum bark can treat symptoms of kidney failure associated with stone formation. [12]
  2. A study also reported that pygeum africanum bark can protect against kidney injury through its anti-inflammatory properties. [13]

Relieves Pain

Studies also found that pygeum africanum bark has potent analgesic properties:

  1. In patients with urinary tract infection, pygeum africanum bark reduced pain associated with urination. [14]
  2. A study also found that pygeum africanum bark can help relieve pain caused by chronic pelvic pain syndrome. [15]

References:

  1. Wang D, Li Y, Hou G, et al. Pygeum africanum: effect on oxidative stress in early diabetes-induced bladder. International Urology and Nephrology. 2010 Jun;42(2):401-408. DOI: 10.1007/s11255-009-9610-5.
  2. Carani C, Salvioli V, Scuteri A, et al. Valutazione urologica e sessuologica del trattamento della patologia prostatica benigna mediante Pygeum africanum ad alte dosi [Urological and sexual evaluation of treatment of benign prostatic disease using Pygeum africanum at high doses]. Arch Ital Urol Nefrol Androl. 1991;63(3):341-345.
  3. Available from https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-prunus-africana-hook-f-kalkm-cortex_en.pdf.
  4. Larré S, Camparo P, Comperat E, et al. Biological effect of human serum collected before and after oral intake of Pygeum africanum on various benign prostate cell cultures. Asian J Androl. 2012;14(3):499-504. doi:10.1038/aja.2011.132.
  5. Boulbès D, Soustelle L, Costa P, et al. Pygeum africanum extract inhibits proliferation of human cultured prostatic fibroblasts and myofibroblasts. BJU Int. 2006;98(5):1106-1113. doi:10.1111/j.1464-410X.2006.06483.x.
  6. Wilt T, Ishani A, Mac Donald R, Rutks I, Stark G. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2002;1998(1):CD001044. doi:10.1002/14651858.CD001044.
  7. Komakech R, Kang Y, Lee JH, Omujal F. A Review of the Potential of Phytochemicals from Prunus africana (Hook f.) Kalkman Stem Bark for Chemoprevention and Chemotherapy of Prostate Cancer. Evid Based Complement Alternat Med. 2017;2017:3014019. doi:10.1155/2017/3014019.
  8. Shenouda NS, Sakla MS, Newton LG, et al. Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo. Endocrine. 2007;31(1):72-81. doi:10.1007/s12020-007-0014-y.
  9. Santa María Margalef, Anna, et al. “[Antimitogenic Effect of Pygeum Africanum Extracts On Human Prostatic Cancer Cell Lines and Explants From Benign Prostatic Hyperplasia].” Archivos Espanoles De Urologia, vol. 56, no. 4, 2003, pp. 369-78.
  10. Maria T. Quiles, Maria A. Arbós, Antònia Fraga, Inés M. de Torres, Jaume Reventós, Juan Morote, Antiproliferative and apoptotic effects of the herbal agent Pygeum africanum on cultured prostate stromal cells from patients with benign prostatic hyperplasia (BPH) , The Prostate, 10.1002/pros.21138, 70, 10, (1044-1053), (2010).
  11. Yoshimura Y, Yamaguchi O, Bellamy F, Constantinou CE. Effect of Pygeum africanum tadenan on micturition and prostate growth of the rat secondary to coadministered treatment and post-treatment with dihydrotestosterone. Urology. 2003;61(2):474-478. doi:10.1016/s0090-4295(02)02155-6.
  12. Gohari AR, Saeidnia S. The role of herbal medicines in treatment of urinary tract diseases. J Nephropharmacol. 2014;3(1):13-14. Published 2014 Jan 1.
  13. Available from https://library.wur.nl/WebQuery/wurpubs/fulltext/342604.
  14. Available from https://www.ema.europa.eu/en/documents/herbal-report/draft-assessment-report-prunus-africana-hook-f-kalkm-cortex_en.pdf.
  15. Available from https://read.qxmd.com/read/31577095/nutraceutical-treatment-and-prevention-of-benign-prostatic-hyperplasia-and-prostate-cancer.