Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptake inhibitor or also known as triple reuptake inhibitor, which means that it inhibits the reabsorption of the neurotransmitters (brain chemicals) serotonin, norepinephrine, and dopamine. This process increases the extracellular concentrations of these neurotransmitters. The therapeutic benefits of tesofensine are attributed to this effect because each of these neurotransmitters exerts an important function at different locations in the brain.
Tesofensine is widely known as a weight loss drug. Researchers believe that tesofensine may help treat obese and overweight patients because it boosts the levels of dopamine in the brain. A deficiency in this neurotransmitter has been shown to be linked with overeating and obesity. [1-5] An overwhelming body of human studies supports the fat-burning effect of tesofensine:
Research indicates that tesofensine helps preserve cognitive health by indirectly potentiating cholinergic neurotransmission, which is a process wherein nerve cells relay messages to each other.  This has been proven to have beneficial effects on various areas of cognitive health, including learning, memory, and thinking skills. The following studies support this effect:
Sustained treatment with tesofensine has been shown to improve overall mood through its antidepressant effect. Studies show that tesofensine affects mood by:
Tesofensine has also been found to have beneficial effects on blood sugar. Studies show that:
Tesofensine treatment is also beneficial in improving one’s productivity by increasing energy levels. In one study, administration of tesofensine in overweight and moderately obese men induced higher energy expenditure compared to placebo. 
Because of its potent antidepressant effect, tesofensine has also been studied for its therapeutic benefits on sexual dysfunction. Studies show that tesofensine administration is effective in treating depression-related sexual dysfunction,  suggesting that it can help ramp up sexual power.
Triple reuptake inhibitor such as tesofensine also holds therapeutic potential for eating disorders. In patients with binge eating disorder, a condition in which a person eats large quantities of food when stressed, tesofensine administration has been shown to improve its symptoms, possibly due to tesofensine’s potent antidepressant effect. [39-42]
ADHD is characterized by short attention span, hyperactivity and impulsivity, and is common in children and even adults. Studies show that this mental disorder is strongly linked with low levels of dopamine and serotonin. [43-45] Since tesofensine’s mode of action is that it increases the levels of these neurotransmitters, this drug may help reduce the symptoms of ADHD.
A deficiency in the neurotransmitter serotonin has been linked to insomnia and various sleeping difficulties, according to studies. [46-50] On the other hand, increasing the levels of serotonin through selective serotonin reuptake inhibitors treatment has been shown to improve objective and subjective sleep quality in patients with sleeping difficulties. [51-53] With tesofensine’s ability to boost serotonin levels, it may have a positive effect on sleep quality, pattern, and duration.
Studies show that low dopamine levels are associated with alcohol addiction. [54-57] With tesofensine’s ability to increase dopamine levels, it may help reduce excessive alcohol intake along with its symptoms. Animal studies even found that in ethanol-preferring rats, triple reuptake inhibitor administration reduced alcohol consumption without decreasing food or water consumption. 
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