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Tiger 17

One of the major health concerns worldwide is hard-to-treat wounds such as diabetes-induced skin ulcers and burn injuries. These wounds require long and sterile treatments as they increase the affected individual’s risk for infection and permanent tissue damage. Recently, clinical trials are being conducted to find the ideal treatment for debilitating wounds. Researchers found that small peptides such as Tiger 17 possess potent wound healing capacity via its actions on the production of wound healing agents such as transforming growth factor beta (TGF-β), and positive effects on the stages of healing.

Overall Health Benefits of Tiger 17

  • Promotes healing of full thickness dermal wound [1]
  • Fights infection [2]
  • Stimulates collagen production and granulation tissue formation [3-4]

Proven Health Benefits of Tiger 17

Promotes Healing of Full Thickness Dermal Wound

Full thickness dermal wound involves damage to the skin and subcutaneous tissue (fat layer). In one study, Tiger 17, a small peptide containing 11 amino acid residues, has been found to exert wound healing effects in a mouse model of full thickness dermal wound. [1] Researchers found that Tiger 17 improves the wound healing process by:

  • Inducing the migration of macrophages (mobile white blood cells) at the site of injury during the stage of inflammation.
  • Promoting the migration and production of keratinocytes and fibroblasts, resulting in the formation of granulation tissue and restoration of the damaged skin structure.
  • Stimulating the tissue remodeling phase by boosting the secretion of transforming TGF-β1 and interleukin 6 (IL-6).

Fights Infection

Tiger 17 may have beneficial effects on wound healing through its antibiotic properties. In one cell study, researchers found that exposure of various microorganisms such as Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli to Tiger 17 reduced bacterial presence. [2] In this study, microorganisms were exposed to Tiger 17 and commercial woven-swabs. Results of the study showed that the presence of bacteria was significantly reduced by Tiger 17 compared to control.

Stimulates Collagen Production and Granulation Tissue Formation

A study found that Tiger 17 has the potential to treat non-healing wounds with deeper layers by stimulating the production of collagen, a protein necessary for the maintenance of skin matrix. [3] This in turn speeds up the formation of granulation tissue (new connective tissue) and microscopic blood vessels at the site of injury during the process of regeneration. Granulation tissue normally forms from the base of a wound, allowing it to fill wounds with deeper layers of almost any size.

In another study, Tiger 17 has been found to improve the wound healing process in mice by promoting migration of keratinocytes and formation of granulation tissue at the site of injury. [4] Since keratinocytes constitute 90% of the cells of the outermost skin layer (epidermis), migration into the wound can accelerate the healing process. Its additional effect on granulation tissue formation can benefit the overall stages of wound regeneration.

References:

  1. Tang J, Liu H, Gao C, et al. A small peptide with potential ability to promote wound healing. PLoS ONE. 2014;9(3):e92082.
  2. Available from http://repositorium.sdum.uminho.pt/handle/1822/57028.
  3. Tang J, Liu H, Gao C, et al. PLoS One. 2014;9:e92082.
  4. Mangoni ML, McDermott AM, Zasloff M. Antimicrobial peptides and wound healing: biological and therapeutic considerations. Exp Dermatol. 2016;25(3):167–173. doi:10.1111/exd.12929.
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