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Viagra

Viagra

Viagra is a brand name of the generic drug known as sildenafil. This drug is commonly used to treat erectile dysfunction (ED). Its mechanism of action works by relaxing the muscles and arteries inside the penis, resulting in increased blood flow. This in turn fills the penis with blood and produces an erection. Aside from its effectiveness in treating sexual dysfunction in men, this drug has also been proven to effectively treat hypertension, cardiovascular disease, cancer, and other medical conditions.

Overall Health Benefits

  • Treats erectile dysfunction [1-7]
  • Lowers risk of heart disease [8-19]
  • Helps lose weight [20-22]
  • Accelerates wound healing [23]
  • Prevents cancer [24-26]
  • Boosts brain power [27-28]
  • Prevents age-related blindness [29-30]
  • Lowers blood pressure [31-34]

Proven Health Benefits

Treats Erectile Dysfunction (ED)

A convincing number of studies support the primary health benefits of Viagra:

  1. Clinical evidence showed the safety and effectiveness of Viagra in treating ED. [1]
  2. In Chinese male patients with ED, the use of Viagra increased sexual satisfaction. [2]
  3. A study conducted in couples showed that men with ED who received Viagra reported better sexual satisfaction. [3]
  4. A 4-year study assessing the effects of Viagra on men with ED found that the treatment was associated with better sexual function and a lower incidence of adverse events. [4]
  5. Studies found that Viagra treatment in men with ED resulted in significant improvement in the quality of erections, successful attempts at sexual intercourse, and overall satisfaction. [5-7]

Lowers Risk of Heart Disease

Studies show that Viagra can help protect against cardiovascular disease by improving blood pressure and other health parameters:

  1. A clinical trial showed that the proper use of Viagra can effectively reduce the risks of heart disease. [8]
  2. A study showed that Viagra can reduce cardiovascular disease risk in hypertensive patients by reducing blood pressure. [9]
  3. A study reported that Viagra can help regulate blood flow to the heart. [10]
  4. In patients with pulmonary hypertension, supplementation with Viagra improved quality of life and cardiopulmonary exercise testing measurements. [11]
  5. In male patients, administration of Viagra significantly decreased blood pressure and heart disease risk. [12]
  6. In Spanish men, Viagra supplementation treated hypertension. [13]
  7. In mice models, Viagra treatment reduced the symptoms of heart disease. [14]
  8. In men with cardiovascular disease, Viagra improved heart function without any adverse effects. [15]
  9. In male patients with heart failure, Viagra supplementation reduced complications associated with the disease. [16]
  10. In patients with heart failure, Viagra supplementation resulted in improved heart performance. [17]
  11. A study showed that Viagra treatment can help prevent heart failure. [18]
  12. In patients with heart disease, Viagra supplementation reduced symptoms of congestive heart failure. [19]

Helps Lose Weight

Viagra has also been shown to promote weight loss and improve body composition:

  1. A study showed that Viagra can help lower the risk of obesity. [20]
  2. A mice study showed that long-term treatment with Viagra prevented weight gain. [21]
  3. In obese mice models, long-term Viagra supplementation gave resistance to obesity by burning excess fat cells. [22]

Accelerates Wound Healing

The ability of Viagra to improve blood flow can have positive effects on wound healing.

In a rat study assessing the effects of topical administration of Viagra on full thickness skin defects, researchers observed a faster wound healing rate. [23] 

Prevents Cancer

Evidence also suggests that Viagra has anti-cancer properties:

  1. In mice models, administration of a daily dose of Viagra prevented colorectal cancer. [24]
  2. In patients with colorectal cancer, Viagra administration prevented the spread of cancer cells especially to those who underwent open surgery. [25]
  3. Studies conducted on Sweden men showed that the use of Viagra was associated with a reduced risk of colorectal cancer. [26]

Boosts Brain Power

Viagra has also been shown to improve cognitive function in patients with brain disorders:

  1. In patients with Alzheimer’s disease (AD), administration of Viagra improved brain performance. [27]
  2. A study showed that Viagra can treat minor cognitive impairments. [28]

Prevents Age-Related Blindness

Studies show that Viagra can be beneficial in patients with age-related vision problems:

  1. A study showed that Viagra can help recover the vision of patients with age-related macular degeneration (AMD). [29]
  2. In patients with AMD, administration of Viagra improved blood flow in the eyes. [30]

Lowers Blood Pressure

Studies support the blood pressure-lowering effects of Viagra:

  1. In adult males, a dose of Viagra resulted in lower blood pressure. [31]
  1. In adult males, Viagra lowered blood pressure and pulse. [32]
  2. A study conducted on hypertensive patients found that Viagra produced therapeutic effects. [33]
  3. A study showed that Viagra alone can effectively lower blood pressure. [34]

References:

  1. Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clin Interv Aging. 2006;1(4):403-414. doi:10.2147/ciia.2006.1.4.403.
  2. Tang WH, Zhuang XJ, Ma LL, et al. Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: a multi-center study. Int J Clin Exp Med. 2015;8(7):11539-11543. Published 2015 Jul 15.
  3. Heiman JR, Talley DR, Bailen JL, Oskin TA, Rosenberg SJ, Pace CR, Creanga DL, Bavendam T. Sexual function and satisfaction in heterosexual couples when men are administered sildenafil citrate (Viagra) for erectile dysfunction: a multicentre, randomised, double-blind, placebo-controlled trial. BJOG. 2007 Apr;114(4):437-47. doi: 10.1111/j.1471-0528.2006.01228.x. Epub 2007 Feb 5. PMID: 17284249.
  4. Four-Year Review of Sildenafil CitrateMcMurray JG, Feldman RA, Auerbach SM, Deriesthal H, Wilson N; Multicenter Study Group. Long-term safety and effectiveness of sildenafil citrate in men with erectile dysfunction. Ther Clin Risk Manag. 2007;3(6):975-981.
  5. Morales A, Gingell C, Collins M, Wicker PA, Osterloh IH. Clinical safety of oral sildenafil citrate (Viagra) in the treatment of erectile dysfunction. Int J Impotence Res. 1998;10:69–74.
  6. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol. 1996;78:257–261.
  7. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 1998;338:1397–1404.
  8. Speakman MT, Kloner RA. Viagra and Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 1999 Oct;4(4):259-267. doi: 10.1177/107424849900400407. PMID: 10684547.
  9. Iosa D. Sildenafil citrate for the treatment of patients with cardiovascular diseases with exclusion of coronary artery disease and hypertrophic subaortic stenosis. Its beneficial effect on patients chronic Chagas’s and diabetic cardioneuromyopathies, hypertensive and hypertrophic cardiomyopathies, with or without chronic congestive heart failure. Rev Fac Cien Med Univ Nac Cordoba. 2003;60(2):23-33. PMID: 14763430.
  10. Available at https://www.ajconline.org/article/S0002-9149(02)03368-4/fulltext.
  11. Available at https://www.nature.com/articles/hr201573.
  12. Lue TF Erectile dysfunction.  N Engl J Med. 2000;3421802- 1813.
  13. Pedro Aranda, Luis M. Ruilope, Carlos Calvo, Manuel Luque, Antonio Coca, Ángel Gil De Miguel, Sildenafil Study Group, Erectile dysfunction in essential arterial hypertension and effects of sildenafil: results of a Spanish national study, American Journal of Hypertension, Volume 17, Issue 2, February 2004, Pages 139–145, https://doi.org/10.1016/j.amjhyper.2003.09.006.
  14. Available at https://journals.physiology.org/doi/full/10.1152/ajpheart.ajpheart.91438.2007.
  15. Tran D, Howes LG. Cardiovascular safety of sildenafil. Drug Saf. 2003;26(7):453-60. doi: 10.2165/00002018-200326070-00002. PMID: 12735784.
  16. Freitas D, Athanazio R, Almeida D, Dantas N, Reis F. Sildenafil improves quality of life in men with heart failure and erectile dysfunction. Int J Impot Res. 2006 Mar-Apr;18(2):210-2. doi: 10.1038/sj.ijir.3901385. PMID: 16121207.
  17. Hirata K, Adji A, Vlachopoulos C, O’Rourke MF. Effect of sildenafil on cardiac performance in patients with heart failure. Am J Cardiol. 2005 Nov 15;96(10):1436-40. doi: 10.1016/j.amjcard.2005.06.091. Epub 2005 Sep 27. PMID: 16275194.
  18. Blum A. Treating heart failure with sildenafil. Congest Heart Fail. 2009 Jul-Aug;15(4):181-5. doi: 10.1111/j.1751-7133.2008.00026.x. PMID: 19627292.
  19. Amin A, Mahmoudi E, Navid H, Chitsazan M. Is chronic sildenafil therapy safe and clinically beneficial in patients with systolic heart failure? Congest Heart Fail. 2013 Mar-Apr;19(2):99-103. doi: 10.1111/chf.12008. Epub 2012 Dec 12. PMID: 23241003.
  20. Moon KH, Park SY, Kim YW. Obesity and Erectile Dysfunction: From Bench to Clinical Implication. World J Mens Health. 2019;37(2):138-147. doi:10.5534/wjmh.180026.
  21. Doghri Y, Chetaneau F, Rhimi M, et al. Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome. PLoS One. 2019;14(11):e0223914. Published 2019 Nov 7. doi:10.1371/journal.pone.0223914.
  22. Available at https://www.uni-bonn.de/Press-releases/viagra-converts-fat-cells.
  23. Cakmak E, Karasoy Yesilada A, Sevim KZ, Sumer O, Tatlidede HS, Sakiz D. Effect of sildenafil citrate on secondary healing in full thickness skin defects in experiment. Bratisl Lek Listy. 2014;115(5):267-71. doi: 10.4149/bll_2014_055. PMID: 25174056.
  24. Mei XL, Yang Y, Zhang YJ, et al. Sildenafil inhibits the growth of human colorectal cancer in vitro and in vivo. Am J Cancer Res. 2015;5(11):3311-3324. Published 2015 Oct 15.
  25. Available at https://www.nature.com/articles/s41467-020-17028-4.
  26. Available at https://www.gastrojournal.org/article/S0016-5085(19)40892-5/fulltext.
  27. Sheng M, Lu H, Liu P, et al. Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer’s Disease. J Alzheimers Dis. 2017;60(4):1351-1364. doi:10.3233/JAD-161006.
  28. Available at https://www.nature.com/articles/s41598-019-53136-y.
  29. Available at https://www.karger.com/Article/FullText/486105#.
  30. Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Liu C. Effect of viagra on retinal vein diameter in AMD patients. Exp Eye Res. 2006 Jul;83(1):128-32. doi: 10.1016/j.exer.2005.11.012. Epub 2006 Mar 10. PMID: 16530757.
  31. Mahmud A, Hennessy M, Feely J. Effect of sildenafil on blood pressure and arterial wave reflection in treated hypertensive men. J Hum Hypertens. 2001 Oct;15(10):707-13. doi: 10.1038/sj.jhh.1001244. PMID: 11607801.
  32. Available at https://www.nature.com/articles/1001244.
  33. Available at https://onlinelibrary.wiley.com/doi/full/10.1111/jch.12850.
  34. Available at https://www.ajconline.org/article/S0002-9149(99)00044-2/fulltext.
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