Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA). It is an experimental drug proposed to help treat medical conditions such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease. This compound is administered into the subcutaneous tissue, which is the fatty area just beneath the skin. In 2021, tirzepatide has completed phase 3 trials.
Tirzepatide works by activating both the GLP-1 and GIP receptors in your body. This triggers the release of insulin from your pancreas that blocks glucagon, a hormone that increases blood sugar levels. As a result, your blood sugar levels can be controlled effectively, especially after a meal. In addition, tirzepatide affects certain chemicals in the brain which in turn decreases food intake, increases energy expenditure, and prevents ectopic fat deposition (abnormal fat accumulation in body parts that normally contains small amounts of fat). These effects result in significant weight reductions.
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA). By acting on these receptors, it produces synergistic effects like increased insulin production and release. This makes tirzepatide more effective than strict GLP-1 agonists that are already approved for the treatment of type 2 diabetes.
By increasing insulin secretion and blocking glucagon, tirzepatide can help lower blood sugar levels. Research indicates that this effect is beneficial in patients with type 2 diabetes (T2D):
Tirzepatide promotes weight loss by affecting certain brain chemicals involved in food intake, energy expenditure, and fat deposition. It does this by acting on the glucagon-like peptide-1 (GLP-1) receptor, which reduces fat cells and enhances fat breakdown. Evidence suggests that these mechanisms are the key to weight loss:
The beneficial effects of tirzepatide on body composition and blood sugar levels can all contribute to a healthy heart. Specifically, tirzepatide increases adiponectin, a protein hormone that regulates the breakdown of fatty acids. Increased adiponectin levels are associated with a lower risk of cardiovascular disease.  In addition, aside from blood sugar, tirzepatide can also protect against heart problems by lowering the levels of triglycerides (blood fat). 
Studies suggest that tirzepatide can lower the risk of cardiovascular disease:
Tirzepatide also has the ability to improve liver health by reducing liver fat. This beneficial effect is backed by a number of studies:
Tirzepatide side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on tirzepatide. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of tirzepatide. Despite this, it was listed as a side effect associated with tirzepatide even though these associated side effects are very uncommon.
Side effects associated with tirzepatide may include the following:
As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA), tirzepatide produces synergistic effects like increased insulin production and release, which gives it an edge over strict GLP-1 receptor agonist such as semaglutide.
An overwhelming body of clinical evidence suggests that tirzepatide is superior to the anti-diabetic medication semaglutide with regards to improving blood sugar levels and reducing body weight:
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