BioPerine

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Overall Health Benefits of BioPerine
Key Takeaways
What is BioPerine?
How BioPerine Works
Chemical Structure of BioPerine
Research on BioPerine
BioPerine Side Effects
Is Bioperine the same as Black Pepper?
Bioperine vs Black Pepper
Bioperine Interactions
Bioperine Mechanism of Action
Bioperine vs Piperine
Bioperine Benefits for Male
Bioperine Benefits for Female
Bioperine Dosage
Bioperine Testosterone
Bioperine and Nutrient Absorption
FAQ
Reference

Overall Health Benefits of BioPerine

Bioperine benefits include improving diabetes symptoms, blood sugar levels, and blood pressure while supporting sexual health, fertility, and tissue regeneration. Additionally, it enhances mood, cognitive health, and kidney health, lowers the risks of stroke, cardiovascular disease, and cancer, and promotes weight loss.

Improves symptoms of diabetes and blood sugar levels [1-5]
Lowers blood pressure [6-9]
Boosts fertility and improves sexual health [10-12]
Speeds up wound healing and tissue regeneration [13-17]
Lowers the risk of stroke [18-21]
Improves kidney health [22-24]
Lowers the risk of cardiovascular disease [25-26]
Improves mood [27-31]
Prevents Alzheimer’s disease (AD) and boosts cognitive health [32-38]
Prevents cancer [39-48]
Promotes weight loss [49-56]

Key Takeaways

Enhanced Bioavailability: BioPerine, derived from black pepper, is known for improving the bioavailability of various nutrients, helping the body absorb more nutrients from food and supplements.
Supports Nutrient Absorption: It aids in the absorption of essential nutrients like vitamins (e.g., vitamin C and vitamin B12), minerals (e.g., selenium), and herbal compounds by enhancing gastrointestinal absorption.
Improves Drug Metabolism: BioPerine can influence drug metabolism by modulating enzyme activity, potentially enhancing the effectiveness of certain medications and reducing the likelihood of nutrient deficiencies.
Potential Health Benefits: Research suggests that BioPerine may have antioxidant properties, which help reduce inflammation and improve overall health by protecting cells from oxidative stress.
Safe and Natural Supplement: As a natural compound, BioPerine is generally considered safe and is commonly included in supplements aimed at enhancing nutrient absorption or improving the efficacy of other active ingredients.

What is BioPerine?

BioPerine is the active ingredient in black pepper that is responsible for its unique spicy flavor. This natural ingredient enhances the bioavailability of certain compounds such as amino acids, water, antioxidants, minerals, and fat-soluble vitamins. BioPerine is a potent substance that contains 95-99% pure piperine, a naturally occurring organic compound that is responsible not only for the pungency of BioPerine but also for its medicinal properties.

How BioPerine Works

BioPerine increases the absorption of nutrients by increasing your body’s metabolism via enhanced thermogenesis (heat production). This process suddenly breaks down your fat cells and increases your body’s internal temperature. BioPerine also has potent anti-inflammatory and immune-boosting properties.

Chemical Structure of BioPerine

Research on BioPerine

A. Improves Symptoms of Diabetes and Blood Sugar Levels

BioPerine improves symptoms of diabetes and blood sugar levels by enhancing the body’s insulin sensitivity and supporting glucose metabolism. It promotes the uptake of glucose by cells, reducing blood sugar levels, and its antioxidant properties help mitigate oxidative stress, which is linked to diabetes complications.

In alloxan-induced diabetic mice, BioPerine administration reduced the dose of metformin and its adverse effects. [1-2]
A study found that BioPerine has anti-hyperglycemic activity (reduces blood sugar). [3]
A study found that BioPerine can help treat symptoms of diabetes through its antioxidant effects against a set of reactive oxygen and nitrogen species. [4]
BioPerine has been found to contribute to the reduction of insulin resistance (inability to respond to the blood sugar-lowering effects of insulin). [5]

B. Lowers Blood Pressure

In Wistar rats, BioPerine decreased blood pressure after 3 weeks of treatment. [6]
A study found that the blood pressure-lowering effects of BioPerine are mediated possibly through blocking calcium channels. [7]
A study found that BioPerine can enhance the efficacy of antihypertensive medications. [8]
A study also showed that BioPerine can reduce blood pressure through its positive effects on blood lipid regulation and its anti-oxidant capacity. [9]

C. Boosts Fertility and Improves Sexual Health

BioPerine boosts fertility and improves sexual health by enhancing the bioavailability of nutrients and compounds that support reproductive function, such as antioxidants and vitamins. Its anti-inflammatory and antioxidant properties help protect reproductive tissues from oxidative stress, improve hormonal balance, and support overall sexual wellness.

In male mice, administration of a fruit extract of black pepper improved sexual drive. [10]
In male albino mice, BioPerine administration resulted in a significant increase in blood levels of testosterone, sperm concentration, and sperm count. [11]
In male Wistar rats, BioPerine administration resulted in increased testosterone levels and sexual excitement. [12]

D. Speeds up Wound Healing and Tissue Regeneration

BioPerine speeds up wound healing and tissue regeneration by enhancing the bioavailability of nutrients and compounds essential for repair processes, such as vitamins, minerals, and antioxidants. It also exhibits anti-inflammatory properties, reducing inflammation at the wound site, and supports improved blood circulation, which delivers oxygen and nutrients to damaged tissues more efficiently, promoting faster recovery.

In elite-level rugby players, supplementation with BioPerine decreased exercise-induced muscle damage. [13]
A study found that BioPerine can enhance the effects of antibacterial antibiotics, which can speed up wound healing. [14]
A study also reported that the anti-inflammatory effects of BioPerine can positively impact wound healing. [15]
In an arthritis animal model, BioPerine exhibited anti-inflammatory effects and reduced pain and other symptoms of the subjects. [16]
A study found that BioPerine can be considered a useful therapeutic and preventive approach for the treatment of inflammation and oxidative stress-related diseases. [17]

E. Lowers the Risk of Stroke

BioPerine lowers the risk of stroke by enhancing the bioavailability of nutrients and compounds with neuroprotective and anti-inflammatory properties, which help improve blood flow and reduce oxidative stress. Its ability to regulate blood pressure and support cardiovascular health further minimizes stroke risk by maintaining the integrity of blood vessels and reducing the likelihood of blockages or ruptures.

A study showed that BioPerine can lower stroke risk through its fat-reducing and lipid-lowering effects. [18]
In mice, BioPerine treatment reduced ischemic stroke-induced brain damage and improved functional outcomes. [19]
A study found that BioPerinecan can lower stroke risk by increasing blood levels of supplemental coenzyme. [20]
A study found that BioPerine protects brain cells against damage. [21]

F. Improves Kidney Health

BioPerine improves kidney health by reducing oxidative stress and inflammation, which are key contributors to kidney damage. Its antioxidant properties protect kidney cells from free radical damage, while its anti-inflammatory effects help mitigate chronic inflammation that can impair kidney function. Additionally, BioPerine enhances the absorption of nutrients and medications that support kidney health.

In rat kidneys, BioPerine inhibited sodium oxalate-induced oxidative stress. [22]
In rats with high-fat diet-induced oxidative stress, BioPerine inhibited oxidative stress in the kidneys. [23]
In rats with lead acetate-induced nephrotoxicity, BioPerine improved kidney function by decreasing the levels of blood urea nitrogen (BUN). [24]

G. Lowers the Risk of Cardiovascular Disease

Bioperine, a patented extract of black pepper, may help lower the risk of cardiovascular disease by improving the bioavailability of nutrients with anti-inflammatory and antioxidant properties. It enhances the absorption of compounds like curcumin, which can reduce oxidative stress and inflammation, both of which are key contributors to heart disease. Additionally, Bioperine may help regulate cholesterol levels and improve blood circulation, further supporting cardiovascular health.

A study found that BioPerine can lower the risk of cardiovascular disease by modulating numerous signaling molecules such as pro-inflammatory cytokines and apoptotic proteins. [25]
In rats fed with a high-fat diet, BioPerine reduced cardiovascular risk by decreasing the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol. [26]

H. Improves Mood

Bioperine, an extract derived from black pepper, improves mood by enhancing the bioavailability of various nutrients, including serotonin and dopamine precursors. By increasing the absorption of these essential neurotransmitters, Bioperine may help regulate mood, reduce symptoms of depression, and support overall emotional well-being. Additionally, it can boost the effectiveness of supplements that promote mood enhancement, leading to a more balanced emotional state.

In a rat model of Alzheimer’s disease, BioPerine reduced anxiety and depression via attenuation of the oxidative stress in the rat amygdala. [27]
A rat study found that BioPerine supplementation significantly reversed chronic unpredictable stress-induced behaviors. [28]
In mice, BioPerine supplementation exhibited antidepressant-like effects as evidenced by an increase in mobility time during a series of tests assessing anxiety and depressive behaviors. [29]
A study found that BioPerine exerts its antidepressant effects by increasing the brain levels of serotonin and dopamine – two neurotransmitters (brain chemical) that regulates mood. [30]
In obese individuals, BioPerine administration for 30 days improved scores on the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scales. [31]

I. Prevents Alzheimer’s Disease (AD) and Boosts Cognitive Health

Bioperine, a patented extract of black pepper, is believed to enhance cognitive health and potentially prevent Alzheimer’s disease by increasing the bioavailability of other nutrients, particularly antioxidants and neuroprotective compounds. It supports brain function by improving the absorption of beneficial substances like curcumin, which has anti-inflammatory and antioxidant effects that protect against neurodegeneration. By reducing oxidative stress and inflammation, Bioperine may help slow the progression of Alzheimer’s and improve cognitive function.

A study found that low doses of BioPerine can disaggregate beta-amyloid plaques in the brain, which is the causative agent of Alzheimer’s disease. [32]
In rats, BioPerine administration reduced the incidence of brain seizures. [33-35]
A study also found that BioPerine is beneficial in improving symptoms of age-associated cognitive decline. [36]
A study reported that BioPerine can interfere with several processes implicated in the early stages of dementia. [37]
A study also reported that BioPerine can help treat or reduce the rates of cognitive decline. [38]

J. Prevents Cancer

Bioperine, a natural compound derived from black pepper, contains piperine, which has been shown to have potential anticancer effects. It works by enhancing the bioavailability and absorption of other beneficial compounds, like curcumin, and has direct antioxidant and anti-inflammatory properties. These actions help inhibit cancer cell growth, reduce inflammation, and prevent DNA damage, potentially lowering the risk of cancer development. Additionally, Bioperine may aid in boosting the immune system’s ability to fight off abnormal cell growth.

A study found that BioPerine acts as a bioavailability enhancer for many chemotherapeutic agents. [39]
In mice with an aggressive form of cancer, BioPerine strongly reduced the growth and development of cancer cells by impairing cellular self-renewal ability, multiplication rate, cell migration, and tumor growth. [40]
A review of several preclinical studies reported that BioPerine can inhibit the invasion, migration, and formation of cancer cells by modulating cell cycle progression and inducing programmed cell death (apoptosis). [41]
In colorectal cancer cells, BioPerine showed anti-cancer effects by inhibiting the canonical Wnt signaling pathway, which is necessary for cancer cell growth and migration. [42]
A cell study also found that BioPerine kills cancer cells by targeting human G-quadruplex DNA sequences. [43]
In bile duct cancer cells, BioPerine induced apoptosis of malignant cells. [44]
When combined with curcumin, BioPerine can produce stronger anti-cancer effects. [45]
In rats with breast cancer, BioPerine slowed the growth rate of tumors. [46]
A study found that BioPerine has chemopreventive activities that do not affect normal cells. [47]
In colorectal cancer cell lines, BioPerine exhibited cytotoxic effects. [48]

K. Promotes Weight Loss

Bioperine, a patented extract of black pepper, promotes weight loss by enhancing the bioavailability of nutrients and increasing thermogenesis. It contains piperine, which has been shown to stimulate metabolism and improve the absorption of essential nutrients, aiding in fat breakdown and energy expenditure. This boost in metabolic rate, combined with better nutrient utilization, can contribute to weight loss when combined with a healthy diet and exercise.

In mice fed with a high-fat diet, supplementation with BioPerine reduced body weight and fat mass. [49]
In obese mice, BioPerine supplementation resulted in significant reductions in body fat percentage and plasma inflammatory markers associated with obesity. [50]
In obese rats, supplementation with BioPerine reduced body weight, fat percentage, and adiposity index. [51-53]
A cell study found that BioPerine can promote weight loss by inhibiting the formation of fat cells. [54]
In diabetic rodent models, BioPerine reduced body fat percentage by increasing the metabolic rate of resting muscle fibers. [55]
In Sprague-Dawley rats, BioPerine reduced body weight, body fat percentage, and cholesterol levels. [56]

BioPerine Side Effects

BioPerine side effects are very uncommon. There have been some side effects associated with its use wherein the patient had one of the issues listed below at some point while being on BioPerine. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of BioPerine. Despite this, it was listed as a side effect associated with BioPerine even though these associated side effects are very uncommon.

Side effects associated with BioPerine may include the following:

Constipation
Nausea
Stomach upset
Diarrhea
Headache
Heartburn
Increased blood pressure (in some individuals)
Allergic reactions (rash, itching, swelling)

It’s important to consult a healthcare provider before using BioPerine, especially if you have preexisting health conditions or are taking medications.

Is Bioperine the same as Black Pepper?

Bioperine and black pepper are related but not identical. Bioperine is a patented extract derived from black pepper (Piper nigrum), standardized to contain at least 95% piperine, the active compound responsible for black pepper’s bioactive properties. While black pepper itself contains piperine along with other components, Bioperine is a concentrated form specifically used in supplements to enhance nutrient absorption and provide consistent potency.

Bioperine vs Black Pepper

Bioperine is a concentrated, patented extract of black pepper that contains at least 95% piperine, the active compound responsible for many of black pepper’s health benefits. In contrast, black pepper is the whole spice that naturally contains piperine in lower concentrations along with other compounds. Bioperine is specifically formulated to enhance the bioavailability of nutrients and supplements, providing a standardized and more potent dose of piperine compared to consuming regular black pepper.

Bioperine Interactions

Bioperine, a concentrated piperine extract from black pepper, can interact with medications and supplements by affecting their absorption and metabolism. It enhances the bioavailability of various drugs and nutrients by inhibiting enzymes like cytochrome P450, which metabolize substances in the liver. While this can improve the effectiveness of certain treatments, it may also lead to higher-than-expected levels of medications in the bloodstream, potentially increasing the risk of side effects. Caution is advised when using Bioperine with prescription medications, particularly anticoagulants, anticonvulsants, or sedatives, and consulting a healthcare provider is recommended.

Bioperine Mechanism of Action

Bioperine, derived from black pepper, primarily enhances nutrient absorption through its influence on thermogenesis and inhibition of enzymes responsible for metabolizing drugs and nutrients, such as cytochrome P450. By increasing gastrointestinal blood flow and enhancing the activity of amino acid transporters, it improves the bioavailability of compounds like vitamins, minerals, and herbal extracts. Additionally, Bioperine’s effect on thermogenesis elevates cellular energy expenditure, which further aids in nutrient uptake and utilization. This mechanism makes it a popular additive in dietary supplements.

Bioperine vs Piperine

Bioperine and piperine are closely related, as Bioperine is a patented, standardized extract containing at least 95% piperine, the active compound in black pepper. While piperine refers to the natural alkaloid found in black pepper, Bioperine is a refined form designed for consistent potency and is widely used in dietary supplements to enhance nutrient absorption. Both share similar benefits, but Bioperine’s standardization ensures reliable efficacy, making it preferred for clinical and supplement applications.

Bioperine Benefits for Male

Bioperine offers several benefits for men, primarily by enhancing the absorption and bioavailability of nutrients and supplements like vitamins, minerals, and herbal extracts. This can support overall health, energy levels, and performance. Bioperine has also been linked to improved testosterone levels and better metabolism, which may aid in muscle building and fat loss. Additionally, its antioxidant and anti-inflammatory properties can contribute to reducing oxidative stress, supporting immune health, and promoting vitality in men.

Bioperine Benefits for Female

Bioperine provides several benefits for women by enhancing the absorption and effectiveness of essential nutrients and supplements, such as vitamins, minerals, and herbal extracts. This can support overall wellness, improve energy levels, and boost skin health through better nutrient delivery. Its antioxidant and anti-inflammatory properties may help combat oxidative stress, promoting hormonal balance and reproductive health. Additionally, Bioperine can aid in weight management by improving metabolism, making it a valuable addition to wellness routines tailored to women’s specific needs.

Bioperine Dosage

The recommended dosage of Bioperine typically ranges from 5 mg to 10 mg per day, depending on individual needs and the formulation of the supplement it is included in. This small amount is sufficient to enhance the bioavailability of various nutrients and compounds by inhibiting metabolic enzymes and improving their absorption in the gastrointestinal tract. It is important to follow the dosage instructions provided on the supplement label or consult a healthcare provider, as excessive intake may cause gastrointestinal discomfort or interactions with certain medications.

Bioperine Testosterone

Bioperine, derived from black pepper, may support testosterone levels indirectly by enhancing the absorption of nutrients and supplements that contribute to hormonal health. For example, it can improve the bioavailability of zinc, magnesium, and other key vitamins, which are essential for testosterone production. Additionally, its anti-inflammatory and antioxidant properties may help reduce oxidative stress, which is known to negatively impact testosterone levels. While Bioperine itself does not directly increase testosterone, its role in nutrient optimization makes it a valuable addition to supplements targeting hormonal balance and male health.Bioperine vs berberine

Bioperine and berberine are distinct compounds with different origins and health benefits. Bioperine, derived from black pepper extract, is primarily used to enhance the bioavailability of nutrients and supplements, improving their absorption and effectiveness. Berberine, on the other hand, is a bioactive compound extracted from various plants and is known for its potent effects on blood sugar regulation, lipid metabolism, and antimicrobial activity. While Bioperine acts as a bioenhancer, berberine directly targets metabolic pathways, such as activating AMPK (adenosine monophosphate-activated protein kinase). The two are sometimes combined in supplements to maximize the benefits of berberine through improved absorption facilitated by Bioperine.

Bioperine and Nutrient Absorption

Bioperine, a patented black pepper extract, significantly enhances nutrient absorption through its active compound, piperine. Piperine increases the bioavailability of various vitamins, minerals, and compounds like curcumin and coenzyme Q10 by inhibiting enzymes that metabolize them too quickly in the liver and intestines. This allows more nutrients to enter the bloodstream and remain active for longer, improving their effectiveness. By optimizing nutrient uptake, Bioperine supports better overall health and maximizes the benefits of supplements and dietary intake.

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FAQ

What is the use of BioPerine?

BioPerine is used to enhance the bioavailability and absorption of nutrients and supplements in the body. It is particularly beneficial for individuals who may experience slow blood clotting, as it helps improve the absorption of essential nutrients. Additionally, slow blood clotting can sometimes be linked to nutrient deficiencies, which BioPerine aids in addressing. By optimizing nutrient absorption, BioPerine supports overall health, including conditions that might affect slow blood clotting.

Is BioPerine the same as black pepper?

No, BioPerine is an extract containing a standardized amount of piperine, the active compound in black pepper, which has been studied for its potential to combat cancer cell growth. Researchers are exploring how BioPerine might enhance nutrient absorption and also contribute to the ability to combat cancer cell growth. While it primarily focuses on improving bioavailability, its potential role to combat cancer cell growth remains a topic of interest.

Does BioPerine help with weight loss?

BioPerine, a form of piperine supplements, may support weight loss by boosting metabolism and improving nutrient absorption, though evidence is limited. Many people consider piperine supplements for their potential health benefits. However, more research is needed to fully understand the effectiveness of piperine supplements in aiding weight loss.

What does piperine do for the body?

Piperine enhances nutrient absorption, including the uptake of beta carotene, supports digestion, and exhibits antioxidant and anti-inflammatory properties. The combination of piperine and beta carotene may amplify their individual benefits. Additionally, piperine’s role in promoting beta carotene absorption makes it a valuable compound in nutritional supplements.

What are the benefits of taking BioPerine?

BioPerine improves the bioavailability of supplements, enhances metabolism, and may support antioxidant and anti-inflammatory responses. Iron and physical activity play a significant role in overall health, and BioPerine may complement their benefits. By optimizing the absorption of nutrients, BioPerine supports the body’s performance, which is essential for those prioritizing iron and physical activity. Additionally, the synergy between BioPerine, iron, and physical activity can contribute to improved metabolic and inflammatory responses.

What are the side effects of BioPerine supplements?

Side effects may include gastrointestinal discomfort, allergic reactions, or interactions with medications. Some people use this approach to boost brain function, but it is essential to consult a healthcare professional. Additionally, while exploring options to boost brain function, be mindful of potential side effects. If you’re looking for ways to boost brain function safely, consider discussing your choices with your doctor.

Is BioPerine just black pepper?

No, BioPerine is a concentrated extract of piperine from black pepper, not whole black pepper itself. It is known to help stabilize blood sugar levels by enhancing nutrient absorption. Unlike regular black pepper, BioPerine offers specific benefits, such as improving metabolic function and helping to stabilize blood sugar levels. Incorporating BioPerine into your routine could support your body’s ability to stabilize blood sugar levels efficiently.

What does BioPerine do to the body?

BioPerine enhances nutrient absorption and supports metabolic and digestive health. When combined with a balanced diet, it maximizes the benefits of essential nutrients. Incorporating BioPerine into your routine can help maintain a balanced diet while promoting overall well-being. A balanced diet, along with BioPerine, ensures optimal nutrient absorption and metabolic support

What are the side effects of BioPerine?

Potential side effects include nausea, gastrointestinal discomfort, and interactions with certain medications. Individuals with bleeding disorders should exercise caution as the condition may increase their susceptibility to these side effects. Additionally, those with a history of bleeding disorders should consult a healthcare provider before use.

Is BioPerine better than black pepper?

BioPerine is more concentrated in piperine, making it more effective for enhancing bioavailability compared to black pepper. This enhanced bioavailability is especially beneficial for water soluble vitamins, which are easily absorbed but also quickly excreted by the body. By improving the absorption of water soluble vitamins, BioPerine ensures that the body retains more of these essential nutrients. Furthermore, the increased concentration of piperine in BioPerine supports the effectiveness of water soluble vitamins in maintaining optimal health.

How much BioPerine is in black pepper?

Black pepper typically contains about 5–9% piperine by weight, while BioPerine is a standardized extract with a higher concentration. Some people take iron supplements to address deficiencies, and the piperine in black pepper may enhance the absorption of these iron supplements. If you’re considering adding iron supplements to your routine, it’s important to consult with a healthcare professional to determine the right dosage for your needs.

What is the difference between piperine and black pepper?

Piperine is the active compound responsible for black pepper’s benefits, including its ability to decrease inflammation. While black pepper contains additional components like essential oils and fiber, piperine plays a key role in reducing inflammation. Regular consumption of black pepper can help decrease inflammation in the body, supporting overall health.

What is the benefit of taking BioPerine?

Research suggests the main benefit of BioPerine is its ability to improve the absorption and effectiveness of other nutrients and supplements. Research suggests that by enhancing nutrient bioavailability, BioPerine can significantly boost the efficacy of various supplements. Additionally, research suggests that this improvement in absorption helps ensure that the body gains maximum benefit from the nutrients consumed.

What is the difference between black pepper and piperine?

Black pepper is the whole spice, while piperine is the active alkaloid extracted from it for specific health benefits. Dried unripe fruit can sometimes be used in conjunction with black pepper for enhanced health effects. The combination of piperine and dried unripe fruit has been explored for its potential benefits in various wellness practices.

What does BioPerine interact with?

BioPerine may interact with medications like blood thinners, anticonvulsants, and drugs metabolized by the liver. Its powerful anti-inflammatory properties could potentially enhance the effects of other medications. When considering BioPerine, it’s essential to be aware of its powerful anti-inflammatory properties, which may affect drug interactions. Always consult a healthcare professional, as the powerful anti-inflammatory properties of BioPerine could impact the safety of certain medications.

What medications does piperine interact with?

Piperine extract can interact with medications such as anticoagulants, antihypertensives, and drugs processed through cytochrome P450 enzymes. It’s important to be aware that piperine extract may affect the metabolism of certain medications. Individuals taking medications that are metabolized by cytochrome P450 enzymes should consult a healthcare provider before using piperine extract.

What are the side effects of BioPerine?

Side effects can include mild digestive discomfort, allergic reactions, or increased potency of medications. The cell membrane plays a key role in the absorption and processing of drugs, which may contribute to these effects. It’s important to consider how the cell membrane interacts with medications, as this can impact their effectiveness and potential side effects.

What medications interact with black pepper extract?

Black pepper extract may interact with medications affecting liver enzymes in the digestive tract, such as anticoagulants, sedatives, and antihypertensives. When taken with certain medications, black pepper extract can influence the way the digestive tract processes these drugs, potentially altering their effectiveness. It’s important to consider how black pepper extract affects the digestive tract and its interactions with medications to avoid unintended side effects.

How does BioPerine work?

BioPerine enhances the absorption of nutrients by inhibiting certain enzymes that metabolize drugs and supplements too quickly. However, research is needed to fully understand its long-term effects on nutrient absorption. Although BioPerine has shown promising results in enhancing the bioavailability of various compounds, more research is needed to determine the full scope of its potential benefits. As with any supplement, research is needed to ensure its safety and efficacy in different populations.

What is the mechanism of action of piperine?

Piperine works by modulating enzyme activity, enhancing gastrointestinal absorption, and affecting drug metabolism pathways, which can contribute to a reduced risk of nutrient deficiencies, including vitamin C. By improving the bioavailability of certain compounds, such as vitamin C, it may also lead to a reduced risk of ineffective drug metabolism. Additionally, its effects on enzyme activity may result in a reduced risk of adverse interactions with other medications, further supporting the body’s ability to maintain adequate vitamin C levels.

What are the pharmacological actions of piperine?

Piperine exhibits anti-inflammatory, antioxidant, antidiabetic, and bioavailability-enhancing effects. Additionally, studies have suggested that folic acid may synergize with piperine to further enhance these benefits. The combination of folic acid and piperine can contribute to improved health outcomes, particularly in managing inflammation and oxidative stress.

What is the mechanism of action of black pepper?

Black pepper’s active compound piperine improves nutrient absorption, benefiting skeletal muscle function, and exerts antioxidant and anti-inflammatory effects that support skeletal muscle health. Additionally, piperine may enhance the bioavailability of nutrients crucial for skeletal muscle repair and growth. Beyond its effects on muscle health, piperine also demonstrates antimicrobial properties that contribute to overall wellness. The antimicrobial properties of piperine may help in fighting infections, further supporting the body’s recovery and performance. Furthermore, piperine’s antimicrobial properties could assist in maintaining a balanced environment within the body, promoting optimal muscle function.

Who should not take BioPerine?

People taking medications metabolized by the liver, pregnant women, or individuals with known allergies should avoid BioPerine, as it can lead to increased absorption of certain substances. This increased absorption could potentially alter the effects of medications and cause adverse reactions. Therefore, those who fall into these categories should be cautious, as the increased absorption of compounds could be harmful.

What does BioPerine do for the body?

BioPerine boosts nutrient absorption, supports digestion, and may improve metabolic functions by promoting healthy blood vessels. It’s important to follow the suggested dose to ensure optimal benefits. The suggested dose of BioPerine can vary depending on individual needs, so it’s always wise to consult with a healthcare provider before use. Additionally, taking the suggested dose can help maximize the effectiveness of BioPerine in supporting your digestive and metabolic health, as well as promoting the health of blood vessels. By supporting blood vessels, BioPerine can contribute to overall well-being.

What are the negative effects of piperine?

Negative effects of piperine, the active ingredient in black pepper, may include gastrointestinal discomfort, potential medication interactions, and allergic reactions. The active ingredient piperine can also affect the absorption of other substances, leading to changes in how medications are metabolized. It is important to be cautious when using products containing piperine as the active ingredient to avoid these potential adverse effects.

Does BioPerine raise blood pressure?

BioPerine is not known to raise blood pressure, though it can interact with blood pressure medications. Additionally, it may influence the production of red blood cells, which are crucial for carrying oxygen throughout the body. While BioPerine doesn’t directly affect red blood cells, its impact on nutrient absorption could indirectly support the health of red blood cells.

Are piperine and BioPerine the same thing?

BioPerine is a branded, standardized extract of piperine, known for its potential to support various physiological functions. The extract enhances the absorption and bioavailability of nutrients, thereby optimizing the physiological functions of the body. By improving nutrient uptake, BioPerine plays a role in supporting the overall physiological functions essential for maintaining health.

Is piperine just black pepper?

No, piperine is the active compound extracted from black pepper, which can have an impact on the immune system. Some studies suggest that piperine may help modulate the immune system when included in your daily dose of supplements. However, it is important to note that piperine’s effects on the immune system are still being researched, and the ideal daily dose for immune modulation has yet to be established. As always, consult with a healthcare professional before incorporating piperine into your daily dose.

Who should avoid piperine?

Individuals with liver issues, pregnant women, or those taking medications metabolized by cytochrome P450 enzymes should avoid the pungent principle piperine. The pungent principle piperine can interact with certain medications, leading to adverse effects. Therefore, it is important for individuals in these categories to avoid piperine to prevent any potential complications.

Does piperine cause a leaky gut?

There is no strong evidence that piperine causes leaky gut, but excessive doses could irritate the gastrointestinal lining, potentially affecting cognitive abilities. While piperine may have some benefits, its impact on cognitive abilities is not well-documented. Excessive doses could lead to irritation, which might indirectly affect cognitive abilities over time.

What does BioPerine do for men?

BioPerine may enhance nutrient absorption and support testosterone levels indirectly by improving overall nutrient bioavailability, which could help in managing viral proteins. Additionally, the improved absorption may also play a role in combating the impact of viral proteins on the body. By supporting better bioavailability, BioPerine may indirectly help in the regulation of viral proteins.

What does black pepper extract do for men?

Black pepper extract may support metabolic health, improve nutrient absorption, and potentially influence testosterone levels due to its diverse physiological effects. The extract’s bioactive compound, piperine, is known to have diverse physiological effects that can enhance the body’s ability to absorb nutrients and regulate metabolic processes. Additionally, the diverse physiological effects of black pepper extract may extend to influencing hormone levels, including testosterone, further supporting overall health.

Does BioPerine affect blood pressure?

BioPerine does not directly affect blood pressure but may interact with antihypertensive medications. Some animal studies suggest that BioPerine could have an indirect influence on blood pressure regulation, especially when combined with certain medications. However, animal studies have not conclusively proven any significant changes in blood pressure due to BioPerine alone.

Does black pepper increase testosterone?

Some studies suggest piperine may support testosterone levels, but evidence from animal studies is limited. While animal studies have shown potential effects, more research is needed to confirm these findings in humans. Overall, the evidence from animal studies is still not definitive.

What is the most powerful supplement for testosterone?

Testosterone boosters like D-aspartic acid, zinc, or ashwagandha are often considered effective supplements due to their medical properties. These ingredients are known to enhance testosterone levels and promote overall health, showcasing their medical properties. Many individuals incorporate these supplements into their routines to take advantage of their potential medical properties for improving vitality and physical performance.

What is the most powerful herb for testosterone?

Ashwagandha is widely regarded as a potent herb for boosting testosterone levels. Studies suggest that caloric restriction can enhance the benefits of ashwagandha, improving its effect on hormone balance. Additionally, research shows that combining ashwagandha with caloric restriction may promote overall health and longevity, further boosting testosterone production.

Is piperine the same as berberine?

No, piperine is an extract from black pepper, while berberine is a bioactive compound derived from certain plants. Both piperine and berberine have properties that may help reduce inflammation in the body. Berberine, in particular, is often used for its potential to reduce inflammation and support various health conditions. However, while piperine can enhance the absorption of certain nutrients, its ability to reduce inflammation is not as prominent as berberine’s.

Is berberine just turmeric?

No, berberine is distinct from turmeric and is derived from plants like barberry and goldenseal. While turmeric is often discussed in relation to its potential benefits for neurological conditions, berberine has its own unique properties. Some studies suggest berberine may have a positive impact on neurological conditions, although its effects differ from those of turmeric. It’s important to explore both when considering options for supporting brain health in the context of neurological conditions.

Why don't doctors prescribe berberine?

Doctors may not prescribe berberine because it is considered a supplement rather than an FDA-approved medication. However, some studies suggest berberine may help manage certain conditions like heart disease. While not an FDA-approved treatment, it is often explored for its potential benefits in supporting heart health, particularly for those at risk of heart disease.

Reference

Atal S, Atal S, Vyas S, Phadnis P. Bio-enhancing Effect of Piperine with Metformin on Lowering Blood Glucose Level in Alloxan Induced Diabetic Mice. Pharmacognosy Res. 2016;8(1):56-60. doi:10.4103/0974-8490.171096.

Bio-enhancing Effect of Piperine with Metformin on Lowering Blood Glucose Level in Alloxan Induced Diabetic Mice

This study highlights the potential of piperine, the active alkaloid in black pepper, as a bio-enhancer for metformin in managing diabetes. In alloxan-induced diabetic mice, combining piperine with both therapeutic and sub-therapeutic doses of metformin significantly improved blood glucose reduction compared to metformin alone. These findings suggest that piperine could enhance the efficacy of metformin, potentially reducing its required dose and associated side effects.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC4753761/.
Atal, Shubham&Agrawal, Rajendra&Vyas, Savita&Phadnis, Pradeep&Rai, Niket. (2012). Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice. Actapoloniaepharmaceutica. 69. 965-9.

Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice

This study explores the effects of piperine, the primary alkaloid in black pepper, on blood glucose levels in alloxan-induced diabetic mice. In acute models, high doses of piperine (40 mg/kg) caused a temporary rise in blood glucose levels, while in subacute models, piperine (20 mg/kg) significantly reduced blood glucose levels by day 14. These findings suggest that while piperine may have antihyperglycemic potential with subacute administration, its effects vary with dosage and duration, warranting further investigation for its use as an antidiabetic agent.

You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/23061294/.
Available from https://www.tandfonline.com/doi/citedby/10.1080/10408398.2019.1565489?scroll=top&needAccess=true.
Hlavackova L, Urbanova A, Ulicna O, Janega P, Cerna A, Babal P. Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition. BratislLekListy. 2010;111(8):426-431.

Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition

This study investigates the effects of piperine, a compound in black pepper, on blood pressure in hypertensive rats induced by chronic NO synthesis inhibition with L-NAME. Piperine (20 mg/kg/day) partially prevented the rise in blood pressure from the third week of treatment, likely through calcium channel blockade and filamentous actin disassembly. While piperine reduced certain structural changes in the aortic media, such as elastin synthesis and myofibril content, it did not affect other L-NAME-induced alterations. These findings suggest piperine’s potential role in mitigating hypertension through specific vascular mechanisms.

You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/21033621/.
Derosa, G., Maffioli, P., & Sahebkar, A. (2016). Piperine and Its Role in Chronic Diseases. Advances in experimental medicine and biology, 928, 173–184. https://doi.org/10.1007/978-3-319-41334-1_8.

Piperine and Its Role in Chronic Diseases

Piperine, an alkaloid found in black pepper and related Piper species, is responsible for the spice’s distinct biting quality and offers numerous health benefits. It exhibits pharmacological effects such as reducing insulin resistance, providing anti-inflammatory benefits, and improving hepatic steatosis. This chapter reviews piperine’s effects, both alone and in combination with other drugs and phytochemicals, in the management of chronic diseases.

You can read the abstract of the article at https://link.springer.com/chapter/10.1007/978-3-319-41334-1_8.
Hlavačková L, Janegová A, Uličná O, Janega P, Cerná A, Babál P. Spice up the hypertension diet – curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension. NutrMetab (Lond). 2011;8:72. Published 2011 Oct 17. doi:10.1186/1743-7075-8-72.

Spice up the hypertension diet – curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension

This study examines the effects of piperine and curcumin on hypertension and aortic remodeling in a rat model of NO-deficient hypertension induced by L-NAME. Both compounds partially prevented blood pressure increases, with curcumin showing greater effectiveness in preserving vascular morphology, including preventing elastin loss. Piperine reduced myofibril content and slightly increased actin, while their combination had effects similar to curcumin alone but less pronounced. These findings suggest that curcumin is more effective than piperine or their combination in mitigating hypertension-related vascular changes.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC3214182/.
Taqvi, Intasar& Shah, Abdul &Gilani, Anwar-ul. (2008). Blood Pressure Lowering and Vasomodulator Effects of Piperine. Journal of cardiovascular pharmacology. 52. 452-8. 10.1097/FJC.0b013e31818d07c0.

Blood Pressure Lowering and Vasomodulator Effects of Piperine

This study investigates the cardiovascular effects of piperine, demonstrating its blood pressure-lowering properties via calcium channel blockade (CCB). Intravenous piperine caused a dose-dependent decrease in mean arterial pressure (MAP) in rats, but higher doses did not enhance the effect. Piperine partially inhibited ventricular contractions and coronary flow in rabbit heart preparations, inhibited high K+-induced precontractions in aortic rings, and caused endothelium-independent vasodilation. However, in Ca²⁺-free conditions, piperine exhibited vasoconstrictive effects, limiting its consistent BP-lowering impact. The study also highlights species-specific differences in piperine’s CCB effects.

You can read the full article at https://journals.lww.com/cardiovascularpharm/fulltext/2008/11000/blood_pressure_lowering_and_vasomodulator_effects.10.aspx.
Damanhouri ZA, Ahmad A (2014) A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices. Med Aromat Plants 3: 161. doi: 10.4172/2167-0412.1000161.

A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

Piper nigrum L. (black pepper), known as the “King of Spices,” is widely valued in traditional medicine for its diverse pharmacological properties and minimal side effects. Its active alkaloid, piperine, enhances the bioavailability of drugs and nutrients by inhibiting metabolizing enzymes. Piper nigrum and piperine exhibit a wide range of activities, including antihypertensive, antiplatelet, antioxidant, antitumor, anti-inflammatory, antibacterial, and hepato-protective effects, among others. This review provides an updated overview of the pharmacognosy, chemistry, and pharmacological advancements related to Piper nigrum.

You can read the abstract of the article at https://www.researchgate.net/publication/270275083_A_Review_on_Therapeutic_Potential_of_Piper_nigrum_L_Black_Pepper_The_King_of_Spices.
Available from https://www.sciencedirect.com/science/article/pii/S2590262819300048.

Black pepper dietary supplementation increases high-density lipoprotein (HDL) levels in pigs

This study investigates the effects of dietary supplementation with black pepper on serum lipoproteins, antioxidant status, and growth in pigs. Supplementing a diet with 3 g/kg of milled black pepper significantly increased high-density lipoprotein (HDL) levels and serum vitamin C, while also showing a tendency to improve food intake and decrease daily growth rates, though not significantly. These findings suggest black pepper’s potential to enhance lipid regulation and antioxidant capacity, supporting its use as a natural food additive for animal health. The results also hint at possible benefits for human lipid metabolism, warranting further research.

You can read the full article at https://www.sciencedirect.com/science/article/pii/S2590262819300048.
Available from https://scialert.net/fulltext/?doi=rjmp.2015.42.47.

Effects of Black Pepper (Piper nigrum Linn.) Extract on Sexual Drive in Male Mice

This study evaluates the effects of black pepper extract on sexual function in male mice. Over 90 days, mice fed with pellets containing aqueous or ethanol extracts of black pepper exhibited significantly shorter courtship latency compared to the control group, indicating enhanced sexual drive. However, there was no difference in mounting frequency between treated groups, though a strong negative correlation was observed between mounting frequency and courtship latency. These findings suggest that black pepper extract may positively influence sexual drive in male mice.

You can read the abstract of the article at https://scialert.net/fulltext/?doi=rjmp.2015.42.47.
Sutyarso, Sutyarso&Muhartono, &Kanedi, Mohammad. (2016). The Effect of Fruit Extracts of Black Pepper on the Fertility Potential of Male Albino Mice. 4. 1-4. 10.12691/ajmbr-4-1-1.

The Effect of Fruit Extracts of Black Pepper on the Fertility Potential of Male Albino Mice

This study explores the potential of black pepper (Piper nigrum L.) extract to improve sexual function in male mice. Over 90 days, mice fed with pellets containing aqueous or ethanol extracts of black pepper demonstrated significantly shorter courtship latency compared to the control group, indicating enhanced sexual drive, although mounting frequency did not differ between groups. A strong negative correlation was observed between mounting frequency and courtship latency (r = -0.968). These findings suggest that black pepper extract may positively influence sexual drive in male mice.

You can read the abstract of the article at https://scialert.net/fulltext/?doi=rjmp.2015.42.47
CONF, Nandia, Septiyorini,SetyoPurwono,DickyMoch Rizal,2020,2020/02/10,The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection,1st International Conference on Community Health (ICCH 2019),Atlantis Press,251,255,24685739,https://doi.org/10.2991/ahsr.k.200204.054,https://doi.org/10.2991/ahsr.k.200204.054 Septiyorini2020.

The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection,1st International Conference on Community Health (ICCH 2019)

This study investigates the erotogenic effects of ethanolic black pepper extract on testosterone levels and brain androgen receptor concentration in male Wistar rats. Rats were divided into groups receiving varying doses of black pepper extract (3.33, 6.66, and 13.32 mg/kg BW), testosterone undecanoate (TU), or Na-CMC for 55 days. Erection capability increased in extract-treated and TU groups until week 5 but declined afterward. Testosterone levels increased initially in the TU, 3.33 mg, and 13.32 mg groups but decreased by week 8. Brain androgen receptor concentrations were lower in all treatment groups compared to Na-CMC. The study concludes that black pepper extract exhibits erotogenic effects by increasing testosterone levels in male rats.

You can read the abstract of the article at https://www.atlantis-press.com/proceedings/icch-19/125933938.
Delecroix B, Abaïdia AE, Leduc C, Dawson B, Dupont G. Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial. J Sports Sci Med. 2017;16(1):147-153. Published 2017 Mar 1.

Curcumin and Piperine Supplementation and Recovery Following Exercise Induced Muscle Damage: A Randomized Controlled Trial

This study examined the effects of curcumin and piperine supplementation on recovery after exercise-induced muscle damage in elite rugby players using a randomized cross-over design. While supplementation moderately reduced the decline in sprint power output 24 hours post-exercise compared to placebo, it did not significantly affect other measures, such as peak torque, jump performance, or muscle soreness. Exercise caused substantial muscle damage, evidenced by decreases in muscle function and increased creatine kinase levels. The findings suggest that curcumin and piperine supplementation can attenuate some, but not all, aspects of exercise-induced muscle damage.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5358025/.
Available from https://openchemistryjournal.com/VOLUME/3/PAGE/75/ABSTRACT/.
Inés Reynoso-Moreno, Israel Najar-Guerrero, NoéEscareño, Mario Eduardo Flores-Soto, JürgGertsch, and Juan Manuel Viveros-Paredes, Journal of Agricultural and Food Chemistry 2017 65 (43), 9435-9442.
Bang, Jun & Oh, Da & Choi, Hyun & Sur, Bong-Jun & Lim, Sung-Jig & Kim, Jung & Yang, Hyung-In &Yoo, Myung&Hahm, Dae-Hyun & Kim, Kyoung. (2009). Anti-inflammatory and antiarthriticeffects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis research & therapy. 11. R49. 10.1186/ar2662.

Anti-inflammatory and antiarthriticeffects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models

This study investigated the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, a phenolic compound in black pepper. In vitro, piperine inhibited IL6 and MMP13 expression and reduced PGE2 production in IL1β-stimulated synoviocytes from rheumatoid arthritis patients. In rats, piperine significantly alleviated pain and arthritis symptoms, reduced paw inflammation, and decreased inflammatory areas in ankle joints. Piperine’s effects were linked to the inhibition of AP-1 nuclear migration. These findings suggest that piperine has potential as a pharmaceutical or dietary supplement for managing arthritis.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC2688199/
Augustine, R., Kalarikkal, N. & Thomas, S. A facile and rapid method for the black pepper leaf mediated green synthesis of silver nanoparticles and the antimicrobial study. ApplNanosci 4, 809–818 (2014). https://doi.org/10.1007/s13204-013-0260-7.

A facile and rapid method for the black pepper leaf mediated green synthesis of silver nanoparticles and the antimicrobial study

This study presents a novel, eco-friendly, and cost-effective method for the rapid green synthesis of silver nanoparticles using Piper nigrum leaf extracts. Unlike conventional green synthesis methods, this approach enables the production of nanoparticles with controllable sizes within minutes. The synthesized nanoparticles demonstrated excellent antibacterial activity against both Gram-positive and Gram-negative bacteria, highlighting their potential for biomedical applications.

You can read the full article at https://link.springer.com/article/10.1007/s13204-013-0260-7
Available from https://pubs.rsc.org/en/Content/ArticleLanding/2019/FO/C8FO02189A#!divAbstract.

Piperine-mediated suppression of voltage-dependent Ca2+ influx and glutamate release in rat hippocampal nerve terminals involves 5HT1A receptors and G protein βγ activation

Piperine, a key alkaloid in black pepper, exhibits neuroprotective effects by inhibiting glutamate release from rat hippocampal synaptosomes. This inhibition is linked to reduced Ca²⁺ influx via N- and P/Q-type calcium channels and does not involve changes in synaptosomal membrane potential. The effect is mediated through presynaptic 5-HT1A receptors and G protein βγ subunits, rather than intracellular Ca²⁺ release or cAMP pathways. These findings highlight piperine’s potential in neuroprotection by modulating glutamatergic excitatory neurotransmission.

You can read the abstract of the article at https://pubs.rsc.org/en/Content/ArticleLanding/2019/FO/C8FO02189A#!divAbstract.
Liu Z, Ran Y, Huang S, et al. Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization. Front Aging Neurosci. 2017;9:233. Published 2017 Jul 21. doi:10.3389/fnagi.2017.00233.

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Ischemic stroke, the most common type of stroke, has limited treatment options, but shifting microglial polarization from the pro-inflammatory M1 state to the anti-inflammatory M2 state shows therapeutic potential. This study demonstrates that curcumin treatment in mice subjected to ischemic stroke significantly reduces brain damage, improves sensorimotor function, and promotes M2 microglial polarization while inhibiting M1-associated pro-inflammatory responses. In vitro, curcumin suppresses pro-inflammatory cytokine production without affecting microglial survival. These findings highlight curcumin’s potential as a therapeutic strategy for reducing ischemic stroke damage and improving recovery.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5519528/.
Shah SS, Shah GB, Singh SD, Gohil PV, Chauhan K, Shah KA, Chorawala M. Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats. Indian J Pharmacol [serial online] 2011 [cited 2020 Sep 3];43:296-9.

Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

This study investigated the effects of piperine on obesity-induced dyslipidemia in male rats fed a high-fat diet (HFD). Piperine supplementation (40 mg/kg) significantly reduced body weight, triglycerides, total cholesterol, LDL, VLDL, and fat mass while increasing HDL levels, with no impact on food intake. These findings suggest that piperine has fat-reducing and lipid-lowering properties, potentially involving Melanocortin-4 receptors, warranting further exploration of its mechanisms.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC3113382/.
Badmaev, Vladimir &Majeed, Muhammed&Prakash, Lakshmi. (2000). Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. The Journal of nutritional biochemistry. 11. 109-13. 10.1016/S0955-2863(99)00074-1.

Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation

A clinical study evaluated the effect of piperine (98% pure) on the bioavailability of coenzyme Q10 in healthy male volunteers. Coenzyme Q10 (90 mg and 120 mg) was administered with or without 5 mg of piperine in single-dose and multi-day trials. While minor increases in plasma Q10 levels were observed in the control group, supplementation with piperine significantly enhanced Q10 plasma levels, with a 30% greater area under the plasma curve after 21 days (p = 0.0348). The bioenhancing effect of piperine is attributed to its thermonutrient properties.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S0955286399000741?via%3Dihub.
Saha, S., Verma, R.J. Polyphenolic extract of Piper nigrum inhibits sodium oxalate induced oxidative stress in rat kidney. Toxicol. Environ. Health Sci. 6, 164–169 (2014). https://doi.org/10.1007/s13530-014-0201-1.

Polyphenolic extract of Piper nigrum inhibits sodium oxalate induced oxidative stress in rat kidney

Polyphenolic extract from Piper nigrum fruits was evaluated for its antioxidant potential against sodium oxalate-induced oxidative stress, a key factor in nephrolithiasis. In female Wistar rats, sodium oxalate caused significant oxidative damage, including increased lipid peroxidation and reduced activities of superoxide dismutase, catalase, and glutathione. Co-incubation with the extract showed protective effects in a concentration-dependent manner, comparable to the standard nephrolithiasis drug, cystone. The study suggests P. nigrum has potential applications in nutraceuticals and food industries for its antioxidant properties, warranting further cellular-level research.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s13530-014-0201-1.
Vijayakumar RS, Surya D, Nalini N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Rep. 2004;9(2):105-110. doi:10.1179/135100004225004742.

Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress

This study examined the effects of black pepper (Piper nigrum L.) and its active component piperine on oxidative stress and antioxidant levels in high-fat diet-fed rats. Rats on a high-fat diet showed increased lipid peroxidation markers (TBARS, conjugated dienes) and reduced enzymic (SOD, CAT, GPx, GST) and non-enzymic (GSH) antioxidant activities in various tissues. Supplementing with black pepper or piperine significantly reduced oxidative stress markers and restored antioxidant enzyme levels to near-normal values. The findings suggest black pepper and piperine can mitigate high-fat diet-induced oxidative damage.

You can read the abstract of the article at https://www.tandfonline.com/doi/10.1179/135100004225004742?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
Sudjarwo SA, Eraiko K, Sudjarwo GW, Koerniasari. Protective effects of piperine on lead acetate induced-nephrotoxicity in rats. Iran J Basic Med Sci. 2017;20(11):1227-1231. doi:10.22038/IJBMS.2017.9487.

Protective effects of piperine on lead acetate induced-nephrotoxicity in rats

This study investigated the nephroprotective effects of piperine against lead acetate-induced renal damage in rats. Lead acetate exposure significantly increased BUN, creatinine, and MDA levels, decreased SOD and GPx activity, and caused histopathological kidney damage. Piperine administration significantly improved kidney histopathology, reduced BUN, creatinine, and MDA levels, and restored SOD and GPx activity in lead acetate-treated rats. The findings suggest piperine as a potential natural therapeutic agent for mitigating lead-induced nephrotoxicity.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5749357/.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218. doi:10.1208/s12248-012-9432-8.

Therapeutic roles of curcumin: lessons learned from clinical trials

Curcumin, a bioactive compound from turmeric, has been extensively studied for its ability to modulate multiple cell signaling pathways and treat various diseases. Clinical trials confirm its safety at doses up to 12 g/day for 3 months and demonstrate its efficacy against pro-inflammatory conditions such as cancer, cardiovascular diseases, arthritis, inflammatory bowel diseases, diabetes, and hepatic and renal disorders, among others. Curcumin exerts its therapeutic effects by targeting signaling molecules like NF-κB, cytokines, and enzymes. It has been tested alone or with other agents using diverse formulations, including nanoparticles and liposomes, showing promise as a versatile treatment option for numerous human diseases.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC3535097/.
Tu Y, Sun D, Zeng X, et al. Piperine potentiates the hypocholesterolemic effect of curcumin in rats fed on a high fat diet. ExpTher Med. 2014;8(1):260-266. doi:10.3892/etm.2014.1717.

Piperine potentiates the hypocholesterolemic effect of curcumin in rats fed on a high fat diet

The combination of curcumin and piperine enhances curcumin’s hypocholesterolemic effects, as shown in a high-fat diet-induced hyperlipidemia model in rats. Co-administration significantly reduced serum and liver levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol, while increasing fecal TC, TG, and bile acid excretion, as well as high-density lipoprotein cholesterol. This combination also upregulated the activity and expression of key lipid-regulating genes, including ApoAI, LCAT, CYP7A1, and LDLR. These findings suggest curcumin and piperine as a promising therapeutic combination for hyperlipidemia.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC4061201/.
Hritcu L, Noumedem JA, Cioanca O, Hancianu M, Postu P, Mihasan M. Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1-42) rat model of Alzheimer’s disease. Behav Brain Funct. 2015;11:13. Published 2015 Mar 29. doi:10.1186/s12993-015-0059-7.

Anxiolytic and antidepressant profile of the methanolic extract of Piper nigrum fruits in beta-amyloid (1-42) rat model of Alzheimer’s disease

The methanolic extract of Piper nigrum fruits demonstrates anxiolytic, antidepressant, and antioxidant properties in a beta-amyloid (1-42) rat model of Alzheimer’s disease. Beta-amyloid-treated rats showed reduced exploratory and swimming activity and increased immobility, indicative of anxiety and depression. Treatment with the extract significantly improved these behaviors and enhanced antioxidant defenses in the amygdala, including increased superoxide dismutase, glutathione peroxidase, and catalase activities, as well as reduced oxidative damage. These findings suggest the extract alleviates anxiety and depression by mitigating oxidative stress in the brain.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC4389991/.
Bhutani MK, Bishnoi M, Kulkarni SK. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. PharmacolBiochemBehav. 2009;92(1):39-43. doi:10.1016/j.pbb.2008.10.007.

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

Curcumin, derived from Curcuma longa, exhibits antidepressant effects by reversing behavioral, biochemical, and neurochemical changes induced by chronic stress in rats, including reducing immobility, inhibiting monoamine oxidase (MAO) activity, and restoring serotonin and dopamine levels. Co-administration with piperine, a bioavailability enhancer, significantly enhances these effects. This study supports the potential of curcumin, particularly in combination with piperine, as a therapeutic approach for depressive disorders.

You can read the full article at https://www.sciencedirect.com/science/article/abs/pii/S009130570800350X?via%3Dihub.
Huang W, Chen Z, Wang Q, et al. Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system. Metab Brain Dis. 2013;28(4):585-595. doi:10.1007/s11011-013-9426-y.

Piperine potentiates the antidepressant-like effect of trans-resveratrol: involvement of monoaminergic system

Trans-resveratrol, a phenolic compound with antidepressant-like effects, demonstrates synergistic efficacy when combined with piperine, a bioavailability enhancer, in mouse models of depression. Co-treatment significantly reduces immobility in behavioral tests and enhances monoaminergic activity in the brain, involving serotonin and noradrenaline pathways, as confirmed by neurochemical and biochemical analyses. This combination may offer a promising approach for developing novel antidepressants with improved efficacy and minimal side effects, though further research is needed to explore its impact on oxidative stress, inflammation, and neuroprotection.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11011-013-9426-y.
Li S, Wang C, Li W, Koike K, Nikaido T, Wang MW. Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res. 2007;9(3-5):421-430. doi:10.1080/10286020500384302.

Antidepressant-like effects of piperine and its derivative, antiepilepsirine

This study demonstrated the antidepressant-like effects of piperine (PIP) and its derivative antiepilepsirine (AES) in mouse models, with both compounds reducing immobility in the forced swimming and tail suspension tests after chronic administration. AES increased dopamine levels in the striatum, hypothalamus, and hippocampus and serotonin levels in the hypothalamus and hippocampus, while PIP enhanced only serotonin levels in these regions. Neither affected noradrenaline levels, and both showed minor monoamine oxidase (MAO) inhibitory activity. PIP’s effects are linked to serotonergic regulation, while AES influences both serotonergic and dopaminergic systems, suggesting distinct mechanisms underlying their antidepressant actions.

You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/17701559/.
Esmaily H, Sahebkar A, Iranshahi M, et al. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015;21(5):332-338. doi:10.1007/s11655-015-2160-z.

An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial

This study investigated the effects of curcumin on anxiety and depression in obese individuals. Thirty participants were randomized to receive either curcumin (1 g/day) or a placebo for 30 days, followed by a wash-out period and crossover to the other treatment. Results showed a significant reduction in anxiety, as measured by the Beck Anxiety Inventory, following curcumin supplementation (P=0.03), but no significant impact on depression symptoms, as assessed by the Beck Depression Inventory (P=0.7). The study suggests that curcumin may have an anti-anxiety effect in obese individuals.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11655-015-2160-z.
Kulkami S, Dhir A, Akula KK. Potentials of curcumin as an antidepressant. Scientific World Journal. 2009;9:1233–41.

Potentials of curcumin as an antidepressant

Major depression is a growing global concern, with many antidepressant drugs offering limited efficacy and significant side effects. Curcumin, a natural compound, has shown promise in animal models of depression, potentially acting by inhibiting monoamine oxidase and modulating serotonin and dopamine release. It may also promote neurogenesis in brain regions like the frontal cortex and hippocampus. However, curcumin’s poor gastrointestinal absorption limits its clinical use. This review discusses curcumin’s pharmacological profile and its antidepressant effects in animal models, emphasizing the need for clinical trials to further explore its efficacy and safety.

You can read the abstract of the article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5823188/.
DU P, Li X, Lin HJ, Peng WF, Liu JY, Ma Y, et al. Curcumin inhibits amygdaloid kindled seizures in rats. Chin Med J (Engl) 2009;122:1435–8.

Curcumin inhibits amygdaloid kindled seizures in rats

This study explored the effect of curcumin on amygdaloid kindling in rats, a model for epilepsy. Different doses of curcumin were administered during the kindling process, and results showed that high doses (100 mg/kg and 300 mg/kg) significantly inhibited the development of seizures. Curcumin-treated rats required more stimulation to evoke seizures and experienced a delay in reaching the more severe stages of seizures. These findings suggest that curcumin may have a potential antiepileptogenic effect, making it a promising candidate for further research in epilepsy treatment.

You can read the abstract of the article at https://pubmed.ncbi.nlm.nih.gov/19567167/.
Jyoti A, Sethi P, Sharma D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav. 2009;14:300–8.

Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis

This study investigated whether curcumin can inhibit the onset and progression of seizures in a FeCl3-induced epileptogenesis model in rats. The results showed that a higher dose of curcumin (1500 ppm) significantly prevented the onset of severe seizures and slowed the progression of generalized seizures. A lower dose (500 ppm) was less effective but still delayed seizure onset. The seizure-suppressing effects of curcumin were attributed to its biochemical, behavioral, and ultrastructural impacts, suggesting that curcumin could be effective in preventing the generalization of seizures and the associated pathogenesis in epilepsy.

You can read the abstract of the article at https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(08)00375-2.
Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res. 2008;22:1660–4.

Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice

This study investigated the effects of acute and chronic curcumin administration on seizures and anxiety in mice. Acute administration of curcumin (100 mg/kg) significantly increased the seizure threshold in the increasing current electroshock (ICES) test, indicating anticonvulsant activity. It also showed an anxiogenic effect in the elevated plus maze and actophotometer tests. However, this anxiogenic effect disappeared after chronic administration of the same dose for 21 days. These findings suggest that curcumin possesses anticonvulsant properties and its anxiogenic effects diminish with long-term use.

You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1002/ptr.2551.
Sarker MR, Franks SF. Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. Geroscience. 2018;40(2):73-95. doi:10.1007/s11357-018-0017-z.

Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies

Curcumin, the active compound in turmeric, has shown potential as a therapeutic for age-associated cognitive decline due to its strong anti-inflammatory and antioxidant properties. Preclinical studies consistently support its efficacy in addressing cognitive impairment and related processes, while clinical studies, though promising, have yielded mixed results. Despite some evidence suggesting curcumin’s effectiveness in reducing oxidative stress and inflammation, the overall clinical findings remain inconclusive. Future research would benefit from targeting specific populations and evaluating biomarkers of cognitive decline in order to better understand curcumin’s therapeutic potential for cognitive impairment.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5964053/.
Mazzanti G, Di Giacomo S. Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?. Molecules. 2016;21(9):1243. Published 2016 Sep 17. doi:10.3390/molecules21091243.

Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?

Curcumin and resveratrol, polyphenols found in turmeric and red wine, respectively, have shown potential neuroprotective effects against neurodegeneration. Epidemiological studies suggest that these compounds may reduce the risk of cognitive disorders, but clinical trials on their use for treating or preventing dementia have yielded disappointing results. While both curcumin and resveratrol affect several processes involved in the early stages of dementia, the trials do not provide conclusive evidence of their therapeutic value. Future studies should focus on long-term trials with high-bioavailability formulations and early diagnosis using biomarkers to better assess their preventive potential.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC6273006/.
Available from http://www.xiahepublishing.com/2472-0712/ArticleFullText.aspx?sid=2&id=10.14218%2FERHM.2018.00024.

Effects of Curcumin on Cognitive Function—A Systematic Review of Randomized Controlled Trials

Curcumin, a polyphenol in turmeric known for its anti-inflammatory, antioxidant, and chemoprotective properties, has shown promise in improving cognitive function in older adults, although questions about its bioavailability remain. A systematic review of five randomized, placebo-controlled trials found significant cognitive improvements in three studies, with curcumin doses ranging from 90 to 4,000 mg/day. Improvements were observed in tests of memory, attention, and cognitive assessment tools. However, gastrointestinal side effects were common, and more standardized, well-designed trials are needed to determine the optimal curcumin form and dosage for cognitive health.

You can read the full article at http://www.xiahepublishing.com/2472-0712/ArticleFullText.aspx?sid=2&id=10.14218%2FERHM.2018.00024.
Rather RA, Bhagat M. Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities. Front Cell Dev Biol. 2018;6:10. Published 2018 Feb 15. doi:10.3389/fcell.2018.00010.

Cancer Chemoprevention and Piperine: Molecular Mechanisms and Therapeutic Opportunities

Piperine, a bioactive alkaloid found in black pepper, has shown promising cancer chemopreventive properties due to its antioxidant, anti-inflammatory, and other therapeutic activities. It inhibits cancer cell proliferation, promotes apoptosis, and affects cancer cells through various mechanisms such as altering redox homeostasis, inhibiting cancer stem cell self-renewal, and modulating autophagy. Piperine also impacts enzymes and transcription factors involved in metastasis and angiogenesis, and can reverse multidrug resistance in cancer cells, enhancing the efficacy of chemotherapeutic agents. This article highlights piperine’s potential as a cancer chemopreventive agent and encourages further research, especially human trials.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5818432/.
Di Meo F, Filosa S, Madonna M, et al. Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis. J ExpClin Cancer Res. 2019;38(1):360. Published 2019 Aug 16. doi:10.1186/s13046-019-1368-8.

Curcumin C3 complex®/Bioperine® has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis

Curcumin-C3complex®/Bioperine®, a formulation that enhances curcumin’s bioavailability, has shown promising anticancer effects in human mesothelioma cell lines and in a mesothelioma xenograft mouse model. In vitro, it inhibited cell proliferation, migration, and invasion, inducing apoptosis via the intrinsic apoptotic pathway. In vivo, it delayed tumor growth by reducing angiogenesis and promoting apoptosis. This formulation may enhance the therapeutic efficacy of conventional drugs and offers a potential alternative approach for treating mesothelioma, particularly when combined with standard pharmacological therapies.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC6698046/.
Manayi A, Nabavi SM, Setzer WN, Jafari S. Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies. Curr Med Chem. 2018;25(37):4918-4928. doi:10.2174/0929867324666170523120656.

Piperine as a Potential Anti-cancer Agent: A Review on Preclinical Studies

Piperine, a compound found in black pepper, has shown promising anticancer properties in various studies. It exhibits chemopreventive effects by enhancing antioxidant systems, boosting detoxifying enzymes, and suppressing cancer stem cell self-renewal. Piperine inhibits the proliferation and survival of cancer cells, modulates the cell cycle, and has anti-apoptotic effects. It also affects enzymes and transcription factors to hinder invasion, metastasis, and angiogenesis, while demonstrating antimutagenic activity and reversing multidrug resistance. Notably, piperine selectively targets cancerous cells without harming normal cells, highlighting its potential for further clinical development.

You can read the abstract of the article at https://www.eurekaselect.com/article/83627.
de Almeida GC, Oliveira LFS, Predes D, et al. Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells. Sci Rep. 2020;10(1):11681. Published 2020 Jul 15. doi:10.1038/s41598-020-68574-2.

Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells

Piperine, an alkaloid found in black and long pepper, has been shown to inhibit the canonical Wnt/β-catenin signaling pathway, which is commonly mutated in over 94% of colorectal cancer cases. It suppresses β-catenin nuclear localization and reduces cell proliferation and migration in colorectal cancer cell lines (HCT116, SW480, and DLD-1) without affecting non-tumoral cells. These findings suggest that piperine has potential as an anti-cancer agent for colorectal cancer by targeting the Wnt pathway.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC7363889/.
Available from https://www.nature.com/articles/srep39239.

Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences

Piperine, a naturally occurring alkaloid known for its antioxidant, anti-mutagenic, and anti-tumor properties, has been found to specifically interact with G-quadruplex DNA structures, particularly at the c-myc promoter region. This interaction is stronger than with double-stranded DNA and leads to apoptosis-mediated cell death in vitro. These findings suggest that piperine could be a promising anti-cancer agent by targeting G-quadruplex structures.

You can read the full article at https://www.nature.com/articles/srep39239.
Sriwiriyajan S, Tedasen A, Lailerd N, et al. Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrumExtract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats. Cancer Prev Res (Phila). 2016;9(1):74-82. doi:10.1158/1940-6207.CAPR-15-0127.

Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrumExtract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

A piperine-free extract from Piper nigrum (PFPE) demonstrated anticancer and cancer-preventive activities in breast cancer cells and in a rat model of NMU-induced mammary tumorigenesis. PFPE inhibited the growth of breast cancer cells, particularly luminal-like ones, by inducing apoptosis. It exhibited selectivity for breast cancer over other cancer types and showed low toxicity, with no adverse effects in acute toxicity studies. In the cancer prevention study, PFPE reduced the incidence of tumors in rats, and in the anticancer study, it significantly slowed tumor growth without affecting biochemical or hematological parameters.

You can read the full article at https://aacrjournals.org/cancerpreventionresearch/article/9/1/74/50459/Anticancer-and-Cancer-Prevention-Effects-of.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026030/.

Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model

This study explored the combination of curcumin and piperine in emulsome nanoformulations for enhanced anticancer effects against colorectal cancer (CRC). Curcumin- and piperine-loaded emulsomes were successfully developed, with uniform, stable dispersions. While piperine alone did not inhibit HCT116 cell proliferation, its combination with curcumin significantly improved its anticancer effects, reducing cell proliferation by about 50%. The combination treatment induced cell cycle arrest and apoptosis, with increased levels of the apoptotic marker Caspase 3. This approach demonstrates the potential for enhanced anticancer activity and warrants further in vivo research.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026030/.
Sriwiriyajan S, Tedasen A, Lailerd N, et al. Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrumExtract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats. Cancer Prev Res (Phila). 2016;9(1):74-82. doi:10.1158/1940-6207.CAPR-15-0127.

Anticancer and Cancer Prevention Effects of Piperine-Free Piper nigrumExtract on N-nitrosomethylurea-Induced Mammary Tumorigenesis in Rats

This study investigated the anticancer and cancer-preventive effects of a piperine-free extract of Piper nigrum (PFPE) on breast cancer cells and in rats with NMU-induced mammary tumors. PFPE inhibited the growth of luminal-like breast cancer cells by inducing apoptosis and showed greater selectivity against breast cancer compared to other cancer cell types. In an acute toxicity study, PFPE exhibited low toxicity, with no mortality or morbidity at a high dose. The treatment slowed tumor growth in rats, with a lower incidence of tumor-bearing rats, suggesting PFPE’s potential as an effective and safe antitumor agent.

You can read the full article at https://aacrjournals.org/cancerpreventionresearch/article/9/1/74/50459/Anticancer-and-Cancer-Prevention-Effects-of.
Zadorozhna M, Tataranni T, Mangieri D. Piperine: role in prevention and progression of cancer. MolBiol Rep. 2019;46(5):5617-5629. doi:10.1007/s11033-019-04927-z.

Piperine: role in prevention and progression of cancer

Piperine, a major alkaloid from Piper longum and Piper nigrum, is explored for its chemopreventive properties in cancer prevention. It offers potential benefits in inhibiting tumorigenesis and metastasis without significant toxicity to normal cells at doses under 250 µg/ml. This review focuses on the molecular and cellular mechanisms through which piperine exerts its protective effects, highlighting its role in supporting a healthy lifestyle and aiding in cancer prevention through natural, non-toxic agents.

You can read the abstract of the article at https://link.springer.com/article/10.1007/s11033-019-04927-z.
Prashant A, Rangaswamy C, Yadav AK, Reddy V, Sowmya MN, Madhunapantula S. In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. Int J Appl Basic Med Res. 2017;7(1):67-72. doi:10.4103/2229-516X.198531.

In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines

This study evaluated the cytotoxic efficacy of an ethanolic extract of Piper nigrum (EEPN) against colorectal carcinoma. Biochemical analysis revealed that 50% EEPN had higher antioxidant, anti-inflammatory, and phenolic content compared to other concentrations. The cytotoxicity was dose- and time-dependent, with the highest cellular inhibition observed at 6 μg/ml of EEPN in colorectal carcinoma cell lines. The results suggest that Piper nigrum, with its promising biochemical and cytotoxic properties, could be a novel therapeutic agent for treating colorectal carcinoma.

You can read the full article at https://pmc.ncbi.nlm.nih.gov/articles/PMC5327611/.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113382/.

Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

This study investigated the effects of piperine on obesity-induced dyslipidemia in rats fed a high-fat diet. After eight weeks, rats were treated with piperine (40 mg/kg) for three weeks. The results showed that piperine significantly reduced body weight, triglycerides, total cholesterol, LDL, VLDL, and fat mass, while increasing HDL levels, without affecting food intake. These findings suggest that piperine has potential fat-reducing and lipid-lowering effects, possibly through mechanisms related to melanocortin-4 (MC-4) receptors.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113382/.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801844/.

Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β

This study explored the effects of curcumin (Cur) and piperine (Pip) on body fat, metabolism, and inflammation in obese mice undergoing caloric restriction (CR). Mice fed a high-fat diet were supplemented with Cur, Pip, or both during CR. Results showed that the Cur+Pip combination enhanced fat loss and reduced inflammation markers, particularly IL-1β and KC/GRO, compared to other groups. Although plasma curcumin metabolites were similar between Cur alone and Cur+Pip groups, Cur+Pip supplementation showed potential in boosting CR effects, suggesting its promise in preventing metabolic syndrome.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801844/.
BrahmaNaidu P, Nemani H, Meriga B, Mehar SK, Potana S, Ramgopalrao S. Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats. ChemBiol Interact. 2014;221:42-51. doi:10.1016/j.cbi.2014.07.008.

Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats

This study investigated the anti-obesity effects of piperine on high-fat diet (HFD)-induced obesity in rats. After inducing obesity, rats were supplemented with varying doses of piperine (20, 30, and 40 mg/kg body weight) for 42 days. The results showed that piperine, particularly at 40 mg/kg, significantly reversed HFD-induced changes in body weight, fat percentage, insulin and leptin sensitivity, and lipid metabolism. The study concluded that piperine is an effective bioactive compound for suppressing obesity-related issues and improving metabolic health.

You can read the full article at https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(14)00223-3.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693419/.

Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats

This study evaluated the antihyperlipidemic and antiobesity effects of piperonal, an active compound in black pepper, in high-fat diet (HFD)-induced obese rats. After 16 weeks of HFD feeding, rats were supplemented with piperonal, which significantly reduced body weight, fat percentage, and adipocyte size, while improving lipid profiles, insulin resistance, and adipocyte hormones. Piperonal also modulated the expression of key genes involved in lipid metabolism and obesity. The most significant therapeutic effect was observed at a dose of 40 mg/kg, supporting piperonal as a potent antiobesity agent and validating its traditional medicinal use.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693419/.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113382/.

Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

This study investigated the effect of piperine on obesity-induced dyslipidemia in rats fed a high-fat diet (HFD). After eight weeks of HFD, rats were treated with piperine (40 mg/kg) for three weeks. The results showed that piperine significantly reduced body weight, triglycerides, total cholesterol, LDL, VLDL, and fat mass, while increasing HDL levels, without affecting food intake. These findings suggest that piperine has fat-reducing and lipid-lowering effects, likely through mechanisms involving Melanocortin-4 (MC-4) receptors, although further research is needed to clarify its exact mechanism.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113382/.
Park UH, Jeong HS, Jo EY, et al. Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells. J Agric Food Chem. 2012;60(15):3853-3860. doi:10.1021/jf204514a.

Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells

This study explored the antiadipogenic effects of black pepper extract and piperine in 3T3-L1 preadipocytes, revealing that both inhibited adipocyte differentiation without cytotoxicity. Piperine significantly reduced the mRNA expression of key adipogenic transcription factors, such as PPARγ, SREBP-1c, and C/EBPβ, and down-regulated PPARγ target genes. Additionally, piperine repressed rosiglitazone-induced PPARγ activity and disrupted the interaction between PPARγ and the coactivator CBP. Microarray analysis further confirmed that piperine modulates genes involved in lipid metabolism. These findings suggest piperine as a potential treatment for obesity-related diseases by inhibiting fat cell differentiation.

You can read the abstract of the article at https://pubs.acs.org/doi/10.1021/jf204514a.
Available from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135373/.

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

This study identifies piperine, a component of black pepper, as a potential treatment for obesity and type 2 diabetes by increasing the metabolic rate of resting skeletal muscle. Piperine was found to destabilize the super-relaxed state of myosin heads in fast-twitch skeletal muscle fibers, enhancing ATPase activity without affecting muscle mechanics. This effect, confirmed by high-throughput screening and single-nucleotide turnover measurements, suggests that piperine could help mitigate obesity and type 2 diabetes by upregulating muscle metabolism. The findings support piperine as a lead compound for developing therapies targeting these conditions.

You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135373/.
Parim B, Harishankar N, Balaji M, Pothana S, Sajjalaguddam RR. Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats. Pharm Biol. 2015;53(9):1318-1328. doi:10.3109/13880209.2014.980585.

Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats

This study investigates the protective effects of various Piper nigrum (PnL) extracts on high-fat diet (HFD)-induced obesity in rats. Oral administration of ethyl acetate or aqueous PnL extracts for 42 days significantly reduced body weight, fat percentage, and fat-free mass in HFD-fed rats. Additionally, the extracts improved metabolic parameters, such as insulin resistance, lipid profile, leptin, and adiponectin levels, while restoring liver enzyme activity and antioxidant levels. These results suggest that PnL extracts can effectively mitigate obesity-related conditions and improve metabolic health in rats.

You can read the full article at https://www.tandfonline.com/doi/10.3109/13880209.2014.980585?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.

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Table of Contents

Overall Health Benefits of BioPerine

Key Takeaways

What is BioPerine?

How BioPerine Works

Chemical Structure of BioPerine

Research on BioPerine

A. Improves Symptoms of Diabetes and Blood Sugar Levels

B. Lowers Blood Pressure

C. Boosts Fertility and Improves Sexual Health

D. Speeds up Wound Healing and Tissue Regeneration

E. Lowers the Risk of Stroke

F. Improves Kidney Health

G. Lowers the Risk of Cardiovascular Disease

H. Improves Mood

I. Prevents Alzheimer’s Disease (AD) and Boosts Cognitive Health

J. Prevents Cancer

K. Promotes Weight Loss

BioPerine Side Effects

Is Bioperine the same as Black Pepper?

Bioperine vs Black Pepper

Bioperine Interactions

Bioperine Mechanism of Action

Bioperine vs Piperine

Bioperine Benefits for Male

Bioperine Benefits for Female

Bioperine Dosage

Bioperine Testosterone

Bioperine and Nutrient Absorption

FAQ

What is the use of BioPerine?

Is BioPerine the same as black pepper?

Does BioPerine help with weight loss?

What does piperine do for the body?

What are the benefits of taking BioPerine?

What are the side effects of BioPerine supplements?

Is BioPerine just black pepper?

What does BioPerine do to the body?

What are the side effects of BioPerine?

Is BioPerine better than black pepper?

How much BioPerine is in black pepper?

What is the difference between piperine and black pepper?

What is the benefit of taking BioPerine?

What is the difference between black pepper and piperine?

What does BioPerine interact with?

What medications does piperine interact with?

What are the side effects of BioPerine?

What medications interact with black pepper extract?

How does BioPerine work?

What is the mechanism of action of piperine?

What are the pharmacological actions of piperine?

What is the mechanism of action of black pepper?

Who should not take BioPerine?

What does BioPerine do for the body?

What are the negative effects of piperine?

Does BioPerine raise blood pressure?

Are piperine and BioPerine the same thing?

Is piperine just black pepper?

Who should avoid piperine?

Does piperine cause a leaky gut?

What does BioPerine do for men?

What does black pepper extract do for men?

Does BioPerine affect blood pressure?

Does black pepper increase testosterone?

What is the most powerful supplement for testosterone?

What is the most powerful herb for testosterone?

Is piperine the same as berberine?

Is berberine just turmeric?

Why don't doctors prescribe berberine?

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