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LL-37, also known as Human Cathelicidin Antimicrobial Peptide (CAMP), is touted as a “mammal’s core tool” to fight off various harmful microorganisms in the body. It’s produced by many cell types including natural killer (NK) cells, white blood cells, and skin cells. In addition, different body systems such as the respiratory system, gastrointestinal tract, testes, and ocular surface also produce LL-37. This powerful peptide has piqued the interest of the research community because its immune-modulating activities have the potential to accelerate tissue recovery and significantly improve the survival rate of patients with chronic debilitating medical conditions.
The human cathelicidin LL-37 serves a critical role in the innate immune system by defending against bacterial infections. LL-37 can interact with the molecules of the cell wall and perforate cytoplasmic membranes resulting in bacterial cell death. In addition, LL-37 helps promote wound closure by stimulating the formation of new blood vessels (angiogenesis).
An overwhelming body of research shows that this antimicrobial peptide regulates various important mechanisms involved in immune function:
Aside from its immune-boosting properties, LL-37 also has potent anti-inflammatory activity according to high-quality studies:
Studies show that LL-37 can help ward off deadly cancers:
Studies also show that this peptide can help stimulate faster regeneration of wounds:
LL-37 has also been found to possess cardioprotective effects:
Studies found that LL-37 is essential for healthy lungs:
Evidence also suggests that LL-37 is vital for bone repair:
LL-37 side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on LL-37. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of LL-37. Despite this, it was listed as a side effect associated with LL-37 even though these associated side effects are very uncommon.
Side effects associated with LL-37 may include the following:
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