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Kisspeptin is a peptide (a short chain of amino acids) that is produced by the hypothalamus in the brain. It plays an important role in human reproduction, secretion of aldosterone (regulates water and salt balance), tumor suppression, and kidney function.
Kisspeptin works by binding to a G-protein-coupled receptor (GPCR). This in turn stimulates the release of gonadotropin-releasing hormone (GnRH), leading to the secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sexual steroids. LH, FSH, and sex steroids act on the gonads to stimulate the production of reproductive cells such as egg cells and sperm cells. By affecting the circulating levels of the hormones LH and FSH, kisspeptin increases testosterone levels.
Kisspeptin has been shown to boost the hormone testosterone, which plays an integral role in reproductive health, bone health, cognitive function, fat distribution, and other vital bodily functions. The testosterone-boosting properties of kisspeptin are backed by a number of studies:
Evidence suggests that kisspeptin has cardioprotective properties:
Kisspeptin also has immune-modulating properties:
Studies found that kisspeptin has the potential to promote weight loss:
A study showed that kisspeptin can be useful in improving UV-induced skin aging by modulating the production of stress-related genes. [18] This suggests that the peptide can be used as a therapeutic option for sun-damaged skin.
The anti-cancer properties of kisspeptin are backed by a convincing number of evidence:
Kisspeptin has also been shown to play a role in maintaining optimal brain function:
Evidence found that kisspeptin can help boost fertility:
Kisspeptin side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on kisspeptin. However, these side effects werenāt confirmed to be associated with the treatment and could have been a coincidence and not related to the use of kisspeptin. Despite this, it was listed as a side effect associated with kisspeptin even though these associated side effects are very uncommon.
Side effects associated with kisspeptin may include the following:
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