KPV is a tripeptide (Lysine-Proline-Valine) that possesses potent anti-inflammatory properties. It’s a C-terminal tripeptide of α-MSH (alpha-Melanocyte-stimulating hormone). Peptides like KPV often act as hormones and relay information from one tissue through the blood to another via biological messengers. Whether given orally or in the form of injections, the KPV tripeptide has the potential to treat immune-mediated inflammatory conditions such as dermatitis, bowel diseases, allergic asthma, and arthritis.
KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways. KPV enters the cell and interacts directly with inflammatory signalling molecules inside the cell. It enters the nucleus of the cell and, once there, can inhibit the interaction of inflammatory substances and molecules. In addition to its anti‐inflammatory effect, KPV also has antimicrobial effects against pathogens such as S. aureus and C. albicans.
Interestingly, KPV appears to only have an effect in the setting of inflammation and it has almost no effect in normal tissue. The main reason for this is that KPV enters the cells using a transporter that is unregulated in case of inflammation. This suggests that the peptide may serve as an effective or preventive medication in inflammatory conditions. If taken regularly, KPV will be available when necessary and the body can simply excrete it if inflammation and other symptoms are not present. Another amazing advantage of KPV is that, unlike alpha-Melanocyte-stimulating hormone, it does not cause skin pigmentation.  Moreover, KPV retains most of the anti-inflammatory properties of alpha-Melanocyte-stimulating hormone but without unpleasant side effects. Another appealing aspect of KPV is that it can be administered via different routes – oral, intravenous (through the veins), subcutaneous (between the muscle and fat), and transdermal (into the dermis of the skin). This allows KPV to be administered in different body areas with a higher level of safety and efficacy.
An overwhelming body of clinical evidence suggests that KPV exerts its strong anti-inflammatory properties through various important mechanisms:
The potent anti-inflammatory properties of KPV may play a role in speeding up the wound healing process. In addition, since KPV does not cause skin pigmentation, this makes it a good candidate for improving wound healing while avoiding unpleasant skin changes. Another mechanism that is thought to contribute to faster wound healing is the immune-boosting effects of KPV, which helps lower the risk of infection during the regeneration process.
The beneficial effects of KPV on wound healing are backed by a number of studies:
The anti-inflammatory effects of KPV make it an ideal treatment for various inflammatory skin conditions. Furthermore, the immune-boosting effects as well as antimicrobial and antifungal properties of this peptide may play a role in improving skin health.
Evidence suggests that KPV has the potential to treat unpleasant skin conditions:
Aside from its potent anti-inflammatory properties, studies show that KPV may help boost immune function by positively affecting the production of immune system cells and other mechanisms:
As a C-terminal tripeptide of α-MSH, KPV exerts protective effects against various forms of nerve damage, suggesting that it can help combat the effect of aging and other medical conditions on nerve health:
Because KPV and α-MSH share similar properties, they may exert the same beneficial effects. There’s increasing evidence that supports that these peptides may be a therapeutic option in stroke:
KPV side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on KPV. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of KPV. Despite this, it was listed as a side effect associated with KPV even though these associated side effects are very uncommon.
Side effects associated with KPV may include the following:
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