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Potential Health Benefits of RAD-140
RAD-140 benefits include increased lean muscle mass, enhanced strength, and improved endurance, making it popular among athletes and bodybuilders. It may also support fat loss and promote faster muscle recovery without the side effects commonly associated with anabolic steroids.
- Improves muscle mass and strength [1-3]
- Fights cancer [4-6]
- Improves brain health [7-12]
- Promotes weight loss [14]
- Improves sexual health [15-18]
- Treats benign prostatic hyperplasia (BPH) [19-20]
- Improves bone health [21-23]
Key Takeaways
- Muscle Growth and Strength: RAD-140 is known to promote significant increases in lean muscle mass and strength, making it popular among bodybuilders and athletes.
- Enhanced Endurance: Users report improved stamina and physical performance, allowing for more intense and prolonged workouts.
- Fat Loss Support: RAD-140 may help reduce body fat while preserving muscle, contributing to a leaner physique.
- Selective Action: As a selective androgen receptor modulator (SARM), RAD-140 targets muscle and bone tissues, minimizing the side effects typically associated with anabolic steroids.
- Potential Neuroprotective Effects: Early research suggests RAD-140 may offer neuroprotective benefits, potentially supporting brain health and cognitive function.
What is RAD-140?
RAD-140, also known as Testolone, is a compound that belongs to the class of molecules called selective androgen receptor modulators (SARMs). Unlike anabolic androgenic steroids, this orally ingestible product is non-steroidal in nature, which means that it has anabolic effects (e.g., increased muscle mass and strength, and accelerated bone growth) with almost zero side effects. This is because RAD-140 interacts only with androgenic receptors of the muscles and bones, but it doesnāt activate these receptors in other body parts.
How RAD-140 Works
RAD-140 works by allowing its molecules to bind to androgen receptors in the body. This, in turn, sends signals to the body, resulting in muscle build-up. This mechanism of action is similar to anabolic steroids. However, RAD-140 binds to androgen receptors only in bone and muscle tissue, making it a potential option for addressing muscle loss related to ageing and chronic diseases while decreasing the side effects.
Chemical Structure of RAD-140 (Selective Androgen Receptor Modulator)
Research on RAD-140
A. Improves Muscle Mass and Strength
RAD-140 improves muscle mass and strength by selectively binding to androgen receptors in muscle and bone tissues, stimulating anabolic activity without affecting other organs. This targeted action promotes rapid muscle growth, enhances protein synthesis, and increases nitrogen retention, which are essential for building and maintaining lean muscle. Users often experience significant gains in strength, allowing for more intense training sessions and faster recovery times. Unlike traditional steroids, RAD-140 offers these benefits with a reduced risk of androgenic side effects, making it a popular choice for those seeking to improve performance and body composition.
- In patients with severe diseases (cancer, AIDS, and multiple sclerosis) that cause muscle wasting, RAD-140 treatment led to weight gain and increased bone and muscle cell growth. [1]
- In bodybuilders, RAD-140 administration increased muscle mass, decreased fat tissue, and improved stamina and endurance during high-intensity interval training. [2]
- In animals, RAD-140 administration appears to increase lean muscle mass. [3]
B. Fights Cancer
RAD-140 may help fight cancer by targeting androgen receptors found in certain cancer cells, particularly in breast cancer. Research suggests that RAD-140 can inhibit the growth of androgen receptor-positive breast cancer cells by blocking their ability to multiply. Unlike traditional hormone therapies, RAD-140 selectively activates androgen receptors in muscle and bone tissue while minimizing effects on other organs. This selective action may reduce cancer cell proliferation without the severe side effects associated with conventional treatments. Although promising, further clinical studies are needed to confirm its safety and effectiveness in cancer therapy.
- In patients with breast cancer, RAD-140 treatment suppressed the growth of cancer cells by blocking the effects of estrogen on tissues. [4-5]
- RAD-140 prevented the production of a protein called estrogen receptor 1 (ESR1), which is known to fuel cancer growth. [6]
C. Improves Brain Health
RAD-140 may improve brain health by exhibiting neuroprotective properties through its selective activation of androgen receptors in the brain. This activation may help protect neurons from degeneration and oxidative stress, which is particularly beneficial in conditions linked to cognitive decline, such as Alzheimerās disease. Preclinical studies suggest that RAD-140 may enhance brain cell survival and reduce the impact of neurotoxic environments. While these effects are promising, further human research is needed to fully understand its long-term impact on brain health.
- In rat models of Alzheimerās disease (AD), RAD-140 administration protected the neurons and decreased the levels of amyloid beta, which are abnormal protein plaques and is considered a hallmark of AD. [7]
- RAD-140 mimics the activation of beneficial androgen pathways in the brain which leads to the growth and development of brain tissues, enhanced neuron communication, memory formation, and cell survival. [8-11]
- In rats, RAD-140 increased the survival of new neurons in the brain. [12]
D. Promotes Weight Loss
RAD-140 may promote weight loss by increasing lean muscle mass and boosting metabolic activity. As muscle tissue requires more energy to maintain, users often experience a rise in their basal metabolic rate (BMR), leading to greater calorie expenditure throughout the day. Additionally, RAD-140 can help preserve muscle during a calorie deficit, which is crucial for maintaining strength while losing fat. By enhancing endurance and physical performance, it allows for more intense workouts, further supporting fat loss. However, its effects on weight loss are indirect and depend on diet and exercise habits.
- Supplementing with RAD-140 can lead to a dramatic fat loss over time. This is because RAD-140 can indirectly decrease fat tissue by increasing muscle mass. This effect also lowers circulating fat molecules known as low-density lipoprotein (LDL), which is implicated in obesity. [13] In addition, having higher levels of muscle mass increases the bodyās metabolism, which ultimately leads to weight loss. [14]
E. Improves Sexual Health
RAD-140 may improve sexual health indirectly by increasing testosterone-like activity in the body, which can enhance libido, sexual performance, and overall vitality. Its anabolic properties may also boost energy levels, muscle mass, and confidence, all of which can contribute to a healthier sex drive. However, since RAD-140 suppresses natural testosterone production during use, these benefits may diminish without proper post-cycle therapy (PCT) to restore hormonal balance.
- In rats, SARMs enhanced the sexual preference of females for males but only if females had previous sexual experience. [15]
- In women, SARMs enhanced and stimulated libido and other parameters of sexuality. [16]
- In female rats that had undergone surgical removal of the ovaries, SARMs increased sexual motivation, with potency and efficacy comparable with testosterone propionate. [17]
- In male rats, SARMs improved various sexual parameters such as mounts, intromissions, ejaculations, and copulation efficiency. [18]
F. Treats Benign Prostatic Hyperplasia (BPH)
RAD-140 may help manage benign prostatic hyperplasia (BPH) by selectively targeting androgen receptors in muscle and bone tissue without significantly stimulating the prostate. Unlike traditional anabolic steroids or testosterone, which can enlarge the prostate, RAD-140ās selective action reduces androgenic effects on the prostate gland. This selective binding may limit prostate growth and potentially alleviate BPH symptoms. Although promising, more clinical research is needed to confirm RAD-140ās effectiveness and safety for treating BPH in humans.
- SARMs at varying doses (5, 10, and 25 mg/kg) decreased prostate weight and were equal in efficacy to finasteride, a medication used mainly to treat BPH. [19]
- Repeated treatment with SARMs decreased prostate weight just like flutamide, a medication for prostate cancer and BPH. [20]
G. Improves Bone Health
RAD-140 improves bone health by selectively binding to androgen receptors in bone tissue, which may enhance bone mineral density and strength. This selective activation mimics the effects of natural androgens, promoting bone growth without affecting other tissues. By stimulating bone-building processes, RAD-140 may help prevent bone loss, particularly in aging individuals or those experiencing hormonal deficiencies. Although research is still ongoing, early studies suggest RAD-140 could be beneficial for maintaining skeletal integrity and reducing the risk of fractures.
- In androgen-deficient rats, SARMs administration prevented bone loss and maintained bone quality by stimulating bone formation while inhibiting bone breakdown. [21]
- In men with late-onset hypogonadism (low levels of sex hormones), SARMs administration increased bone mineral density and strength just like testosterone replacement therapy. [22]
- In castrated male rats, SARMs administration led to a significantly larger increase in total body bone mineral density. [23]
RAD-140 Side Effects
RAD-140 side effects are very uncommon. There have been some side effects associated with the use of this drug, wherein the patient had one of the issues listed below at some point while being on RAD-140. However, these side effects werenāt confirmed to be associated with the treatment and could have been a coincidence and not related to the use of RAD-140. Despite this, it was listed as a side effect associated with RAD-140, even though these associated side effects are very uncommon.
Side effects associated with RAD-140 may include the following:
- Acne
- Aggression
- Hair loss
- Headache
- Hormonal disorder
- Nausea
RAD 140 vs MK 677
RAD-140 (Testolone) and MK-677 (Ibutamoren) are both popular in fitness and bodybuilding but serve different functions. RAD-140 is a selective androgen receptor modulator (SARM) known for its powerful muscle-building effects, strength gains, and neuroprotective properties, making it ideal for lean muscle growth and performance enhancement. On the other hand, MK-677 is a growth hormone secretagogue that boosts natural growth hormone and IGF-1 levels, promoting muscle recovery, fat loss, better sleep, and increased appetite. While RAD-140 is favored for fast, dry muscle gains, MK-677 is often used for long-term muscle preservation and overall well-being. Some users combine them to maximize muscle growth, recovery, and strength.
Most evidence suggests that any fertility-related effects from RAD-140 are reversible with proper post-cycle therapy (PCT) to restore natural hormone levels. However, the lack of extensive human studies means the long-term risks remain unclear. Individuals concerned about fertility should approach RAD-140 with caution and consider consulting a healthcare professional before use.
RAD vs RAD 140
RAD-150 vs. RAD-140: Key Differences
RAD-150 and RAD-140 are both selective androgen receptor modulators (SARMs) known for promoting muscle growth and enhancing physical performance. The primary difference lies in their chemical structureāRAD-150 is an esterified version of RAD-140, which allows for a slower release and longer half-life in the body. This means RAD-150 may require less frequent dosing while providing sustained effects, whereas RAD-140 typically needs more consistent administration to maintain optimal results.
Performance and Benefits Comparison
Both compounds are valued for their ability to increase lean muscle mass, strength, and endurance while aiding in fat loss. RAD-150’s extended half-life may lead to a more gradual and steady release, potentially reducing the risk of hormonal fluctuations. On the other hand, RAD-140 is known for delivering quicker results due to its faster absorption. Users of both SARMs report improved recovery times and enhanced athletic performance, but RAD-150’s longer activity window may be preferable for those seeking a more consistent anabolic effect.
Side Effects and Considerations
While both RAD-150 and RAD-140 are designed to target muscle and bone tissues selectively, they may still cause side effects such as hormonal suppression, mood changes, or mild liver stress. RAD-150ās esterified form could result in smoother effects and fewer side effects related to hormone spikes, while RAD-140’s quicker action may increase the likelihood of short-term hormonal imbalances. As with any SARM, responsible use, proper post-cycle therapy (PCT), and regular health monitoring are essential to minimize risks.
LGD 4033 vs RAD 140
LGD-4033 vs RAD-140: Muscle Growth and Strength
Both LGD-4033 (Ligandrol) and RAD-140 (Testolone) are popular selective androgen receptor modulators (SARMs) known for enhancing muscle growth and strength. LGD-4033 is often favored for gradual, steady gains in lean muscle mass, making it ideal for beginners or those seeking moderate muscle development. In contrast, RAD-140 is recognized for delivering faster, more substantial muscle gains and increased strength, which appeals to experienced users aiming for significant performance improvements.
Side Effects and Safety
While both compounds are designed to selectively target muscle and bone tissues, they carry potential side effects. LGD-4033 is generally considered milder, with a lower risk of hormonal suppression and minimal androgenic effects. RAD-140, however, is more potent and may cause more pronounced testosterone suppression and mood changes. Post-cycle therapy (PCT) is typically recommended after using either SARM to help restore natural hormone levels.
Best Use Cases
LGD-4033 is ideal for those seeking a balanced approach to muscle building with fewer side effects, making it suitable for longer cycles and beginners. On the other hand, RAD-140 is better suited for advanced users focused on maximizing muscle mass and strength in a shorter timeframe. The choice between the two depends on individual goals, experience level, and tolerance for potential side effects.
FAQ
Does RAD140 ruin testosterone?
RAD140 can suppress natural testosterone production during and after use, but it typically does not cause permanent damage if proper post-cycle therapy (PCT) is followed. However, testosterone suppression is a probable adverse drug reaction associated with RAD140 use, especially among bodybuilding enthusiasts seeking muscle gains.
What does RAD140 do to your brain?
Preliminary research suggests RAD140 may have neuroprotective properties, potentially protecting brain cells from degeneration. Unlike anabolic androgenic steroids, it selectively targets androgen receptors, reducing unwanted side effects. In the context of body building, RAD140 is favored for its ability to enhance muscle growth while minimizing adverse effects. However, long-term effects on the brain in humans remain unclear.
Is RAD140 hard on the liver?
RAD140 may cause mild liver stress, but severe liver damage is uncommon with responsible use. Regular liver function monitoring is recommended during a cycle, especially for individuals concerned about ageing, chronic diseases, and the impact of nutritional supplements on overall liver health. Medical research suggests that proper dosage and monitoring can help mitigate potential liver-related risks.
Is RAD140 bad for the kidneys?
There is limited evidence suggesting RAD140 directly harms the kidneys, but improper use, dehydration, or extended cycles could increase the risk of kidney strain and may lead to an adverse reaction, according to findings from the toxicology research group. Additionally, hepatic safety is a concern, as prolonged use may place stress on the liver.
What does RAD140 do to the brain?
RAD140 may promote neuroprotection by stimulating androgen receptors in the brain, potentially safeguarding against cognitive decline. However, past or present use of RAD140 could pose risks, including acute liver failure, especially with prolonged or high-dose cycles. Blood investigations are recommended to monitor liver function and overall health during and after use. More research is needed for definitive conclusions.
Does RAD140 increase testosterone?
No, RAD140 does not increase natural testosterone. Instead, it suppresses testosterone production during use, which, if unmanaged, could contribute to conditions like acute liver failure. Patient’s laboratory reports are essential for monitoring hormone levels and liver function, and post-cycle therapy is required for hormonal recovery.
Is RAD140 bad for your liver?
RAD140 can cause liver strain if used improperly or for extended periods, though it is not as hepatotoxic as anabolic steroids. It is sometimes researched for its potential to combat muscle-wasting diseases. In some cases, it may contribute to acute liver injury or induced jaundice, making regular health monitoring advisable.
Is RAD140 bad for your kidneys?
RAD140 is not directly linked to kidney damage, but using it irresponsibly can increase the risk of kidney stress, especially if hydration and dosage are not managed properly. Individuals with a known family history of autoimmune liver disease, viral hepatitis, or other pre-existing conditions should exercise caution and consult a healthcare professional before use.
Does RAD140 affect testosterone?
Yes, RAD140 suppresses natural testosterone production while in use. Without post-cycle therapy, testosterone levels may take time to return to normal, and an adverse drug reaction could occur if the body struggles to restore hormonal balance. Additionally, other liver biochemistry results may indicate stress or dysfunction during RAD140 use, highlighting the importance of regular health monitoring.
Does RAD140 cause gyno?
RAD140 is not known to directly cause gynecomastia (gyno) due to its selective action. However, hormonal imbalances from testosterone suppression may increase the risk, and changes in liver biochemistry could further contribute to hormonal disruptions, especially in individuals with an autoimmune disease. Additionally, RAD140 may exert anabolic effects on muscle tissue, which can influence hormone levels and increase the likelihood of hormonal imbalances.
Will RAD140 show up on a drug test?
Yes, RAD140 can be detected on specialized sports drug tests, particularly those used by organizations that screen for performance-enhancing drugs, monitor liver biochemistry for potential health risks, and investigate symptoms like abdominal pain.
Does RAD140 cause liver damage?
There is a potential for mild liver toxicity with RAD140, especially when used in high doses or over long periods. Monitoring liver biochemistry and liver enzymes during use is recommended, particularly for individuals aiming to increase lean body mass. In clinical pharmacology, regular assessments of liver function are crucial to detect early signs of hepatotoxicity and ensure safe usage.
What is better than MK-677?
It depends on your goalsāRAD140 is better for muscle growth and strength, while other SARMs like LGD-4033 or YK-11 may offer faster muscle gains or different anabolic effects. Additionally, RAD140 may help combat muscle wasting, making it a potential option for those seeking to preserve lean muscle mass. Regular monitoring of total serum bilirubin concentration is recommended during RAD140 use to assess liver health and detect potential side effects.
Does RAD140 damage the liver?
While not as toxic as traditional steroids, RAD140 can cause mild to moderate liver stress, especially with long-term use or high dosages, increasing the risk of severe cholestatic liver injury and drug-induced liver injury. Monitoring total serum bilirubin concentration can help assess liver function and detect early signs of liver damage.
Does MK-677 increase bone size?
MK-677 may improve bone density over time by stimulating growth hormone and IGF-1 production, but it does not significantly increase overall bone size. Monitoring total serum bilirubin concentration is important, as improper use of MK-677 could pose risks, including severe liver injury in rare cases due to associated hepatotoxicity.
Does RAD140 lower testosterone?
Yes, RAD140 suppresses natural testosterone production during a cycle and may lower levels post-cycle without proper recovery protocols, though it is generally considered less suppressive than traditional anabolic androgenic steroids. In some cases, a liver biopsy may be necessary to assess potential liver damage from prolonged or high-dose use. Some users also explore herbal supplements to support liver health and hormone recovery during and after a cycle.
What are the long-term side effects of RAD140?
Long-term side effects are not fully understood but may include hormonal imbalance, liver strain, cardiovascular issues, bile acid concentration changes, chronic hepatitis, serious adverse events, and potential suppression of natural testosterone production.
What do SARMs do to your hormones?
SARMs selectively bind to androgen receptors, influencing hormone levels by increasing muscle growth while suppressing natural testosterone during and after use, similar to anabolic androgenic steroids nandrolone in their muscle-building effects but with potentially fewer side effects. Blood tests can help monitor hormone levels and detect any adverse effects during SARM use. However, some supplements included substances unapproved by regulatory agencies, raising concerns about safety and long-term health impacts.
Is RAD140 toxic to the liver?
RAD140 may cause mild liver toxicity, particularly with prolonged use, though it is generally less toxic than traditional anabolic steroids. In cases of recreational and athletic use, severe liver damage, including mild focal lobular inflammation, may occur. A liver transplant may be required in extreme cases, although this is rare with responsible use.
What does RAD140 do to the body?
RAD140 enhances muscle growth, increases strength, supports fat loss, and may provide neuroprotective benefits. It also suppresses natural testosterone production and may have potentially immune-mediated effects. Medical research council grants have supported studies investigating its effects on muscle and bone health, though concerns about severe hepatotoxicity have been raised with prolonged or high-dose use.
How bad is RAD140 for the liver?
When used responsibly, RAD140 poses minimal liver toxicity, but improper dosing or prolonged use can elevate liver enzymes and increase health risks. For a clinical pharmacology trainee participant, it is essential to take a thorough drug history before use to identify potential interactions and minimize risks, especially for those involved in body building who may combine it with other supplements or performance enhancers.
Does RAD140 decrease testosterone?
Yes, RAD140 suppresses testosterone production during and after use, making post-cycle therapy essential to restore hormone balance and prevent complications related to other liver disease, especially for those involved in body building.
How long does LGD-4033 stay in your system?
LGD-4033 has a half-life of approximately 24-36 hours and can remain detectable in the body for up to 5-6 weeks, depending on metabolism and dosage. Its preclinical and clinical development has provided insights into its pharmacokinetics and potential therapeutic applications, especially in body building for promoting muscle growth and recovery.
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