Phentermine

Author: Dr. George Shanlikian, M.D.  |   Last Updated: May 21st, 2025

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Potential Health Benefits of Phentermine

  • Promotes healthy weight loss [2-38]
  • Lowers blood pressure [39-45]
  • Improves heart health [46-50]
  • Treats sleep problems [51-52]
  • Lowers cholesterol levels [53-55]

What is Phentermine?

Phentermine is used for a limited period of time (3 to 6 weeks) to significantly reduce weight in overweight and obese individuals. This FDA-approved weight loss medication belongs to a class of drugs known as sympathomimetic amines. It works by suppressing your appetite while increasing your energy expenditure. By stimulating the release of brain chemicals that will manipulate your mind to feel full with lesser food intake, phentermine helps achieve your weight loss goals without any adverse side effects. [1] This drug comes as tablets and extended-release capsules and is sold under the names Adipex or Suprenza.

How does Phentermine Work?

Phentermine is an anorectic drug, which means it is an appetite suppressant. The drug stimulates the release of chemicals, or neurotransmitters, in the brain. The neurotransmitters whose levels are increased by this drug are norepinephrine, dopamine, and serotonin.

Chemical Structure of Phentermine

Phentermine

Research on Phentermine

Promotes Healthy Weight Loss

Phentermine is a prescription medication that promotes healthy weight loss by suppressing appetite and increasing energy levels. It stimulates the central nervous system, helping reduce hunger and support calorie restriction, making it easier for individuals to adopt healthier eating habits and exercise routines. Often used in short-term weight management plans, phentermine is most effective when combined with lifestyle changes such as a balanced diet and regular physical activity.

    1. An analysis of several clinical trials found that phentermine can result in a weight loss of 3.6 kg at six months compared with placebo treatment. [2]
    2. In obese subjects, phentermine administration initially at 15 mg daily and slowly up-titrated to 37.5 mg daily resulted in a 13% reduction in baseline peak weight. [3]
    3. In obese or overweight patients with weight-related comorbidities, treatment with phentermine consistently demonstrated statistically significant weight loss after 56 weeks compared with placebo. [4-5]
    4. When combined with other weight loss drugs, phentermine can produce greater weight loss. [6-14]
    5. In one-hundred-eight obese women, continuous daily phentermine administration resulted in a mean weight loss of 27 pounds (12.2 kg) while intermittent phentermine (4 weeks on therapy and 4 weeks off of therapy) resulted in a mean weight loss of 28.7 pounds (13 kg). [15]
    6. Several studies also found that phentermine only reduces weight during the time that it is being taken. [16-22]
    7. When combined with topiramate, an anti-seizure drug, phentermine produced significant weight loss without any adverse side effects. [23-29]
    8. Studies suggest that phentermine promotes weight loss by inducing changes in eating behavior. [30-34]
    9. Studies found that overweight and obese patients as young as 3 years and as old as 88 years can be safely treated with phentermine. [35-36]
    10. An analysis of 6 studies found that patients using 15-30 mg of phentermine daily for 2 to 24 weeks had a mean total weight loss of 6.3 kg. [37]
    11. In healthy obese people, short-term phentermine administration significantly reduced weight and waist circumference without clinically problematic adverse events. [38]

Lowers Blood Pressure

While phentermine is primarily used as an appetite suppressant for weight loss, its indirect effect of promoting fat reduction can lead to lowered blood pressure in some individuals. As excess weight is a significant contributor to hypertension, the weight loss achieved with phentermine may help reduce strain on the cardiovascular system and improve overall heart health. However, phentermine itself can increase heart rate and blood pressure in some users, so its effects should be monitored by a healthcare professional.

    1. In overweight hypertensive patients, phentermine administration reduced blood pressure and was well tolerated. [39]
    2. In obese patients, phentermine treatment improved blood pressure and prevented the progression to hypertension. [40]
    3. The Swedish Obese Subjects (SOS) study found that phentermine reduced the incidence of hypertension by 2.6 times. [41]
    4. In overweight and obese individuals with type 2 diabetes, phentermine treatment was associated with a 5-mmHg decrease in diastolic blood pressure. [42]
    5. A recent phentermine clinical trial conducted in healthy obese patients reported a slight decrease in blood pressure. [38]
    6. In obese patients, administration of a 30 mg capsule of phentermine daily over a period of 12 weeks significantly reduced blood pressure. [43]
    7. In hypertensive patients, phentermine reduced systolic blood pressure by −7.5 to −11.8 mmHg. [44]
    8. In both lean and diet-induced obese mice, phentermine significantly reduced blood pressure. [45]

Improves Heart Health

Phentermine may contribute to improved heart health indirectly by promoting weight loss, which can reduce risk factors such as high blood pressure, high cholesterol, and insulin resistance. As excess body weight is a major contributor to cardiovascular disease, shedding pounds with the help of phentermine can ease the workload on the heart and improve overall circulation. However, because phentermine is a stimulant, it must be used under medical supervision to ensure it does not elevate heart rate or blood pressure to unsafe levels.

    1. Patients using phentermine had lower rates of hospitalization for acute myocardial infarction. [46]
    2. Phentermine increases heart rate due to its amphetamine-like side effect. [47]
    3. In overweight and obese adults with metabolic abnormalities, phentermine was associated with a slight increase in heart rate (0.1 to 1.3 beats per minute). [48-49]
    4. Since phentermine promotes weight loss, it can significantly reduce cardiovascular mortality for the following 4-5 years even in patients with pre-existing heart disease. [50]

Treats Sleep Problems

Phentermine is not typically used to treat sleep problems and may actually cause insomnia as a side effect due to its stimulant properties. As a central nervous system stimulant, taking phentermine increases alertness and energy, which can interfere with normal sleep patterns if taken too late in the day. While it aids in weight loss by suppressing appetite and boosting metabolism, individuals taking phentermine should be cautious about its potential impact on sleep and discuss any sleep-related issues with their healthcare provider.

    1. In obese subjects with moderate to severe obstructive sleep apnea who were unable or unwilling to comply with standard treatment, administration of phentermine 15 mg plus extended-release topiramate 92 mg significantly reduced symptoms. [51]
    2. In obese adults, phentermine treatment reduced the incidence of apnea. [52]

Lowers Cholesterol Levels

Phentermine may help lower cholesterol levels indirectly by promoting weight loss, which is often associated with improvements in lipid profiles. As individuals lose weight, levels of LDL (bad cholesterol) and triglycerides tend to decrease, while HDL (good cholesterol) may increase. By suppressing appetite and supporting calorie reduction, phentermine aids in reducing overall body fat, which plays a crucial role in improving cholesterol balance and supporting cardiovascular health.

    1. In obese patients, phentermine administration resulted in lower total cholesterol and low-density lipoprotein (bad cholesterol) concentrations. [53]
    2. A review of the metabolic effects of phentermine found that this drug exerted favorable effects on lipid profile, especially on high-density lipoprotein (good cholesterol) and triglycerides. [54]
    3. In patients with abnormal lipid profiles, phentermine treatment was associated with significant improvements in blood levels of high-density lipoprotein (good cholesterol) and triglyceride as well as a net reduction in lipid-lowering medication use. [55]

Associated Side Effects of Phentermine

Phentermine side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on phentermine. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of phentermine. Despite this, it was listed as a side effect associated with phentermine even though these associated side effects are very uncommon.

Side effects associated with phentermine may include the following:

  • Constipation
  • Dry mouth
  • Erectile dysfunction
  • High blood pressure
  • Increased heart rate
  • Insomnia
  • Nervousness
  • Sleeplessness
  • Tingling or prickling feeling in the hands and feet
  • Tremors

Phentermine Pills

Phentermine is a prescription medication primarily used as an appetite suppressant to aid weight loss in individuals who are overweight or have weight-related medical conditions. It belongs to a class of drugs known as sympathomimetic amines and works by stimulating the central nervous system, which increases heart rate and reduces appetite. Often prescribed as a short-term treatment alongside a low-calorie diet and regular exercise, phentermine helps individuals jumpstart their weight loss journey by decreasing hunger and food cravings.

Phentermine pills come in various forms, including tablets and capsules, and are typically taken once a day, either before breakfast or one to two hours after. The dosage may vary depending on the individual’s medical condition, response to treatment, and body weight. Common brand names include Adipex-P, Lomaira, and Suprenza. Patients using phentermine should be closely monitored by healthcare providers due to the potential for side effects such as increased blood pressure, dizziness, dry mouth, insomnia, or nervousness.

While phentermine can be highly effective in promoting short-term weight loss, it is not a long-term solution and should be used as part of a comprehensive weight management plan. Its use is typically limited to a few weeks, and it’s essential to adopt healthy lifestyle changes for sustainable results. Phentermine is also not suitable for everyone, particularly individuals with a history of cardiovascular disease, hyperthyroidism, or glaucoma. Consulting with a healthcare provider before starting phentermine ensures safe and effective use tailored to individual health needs.

Phentermine Tablets

Phentermine tablets are a widely prescribed weight loss aid designed to help individuals struggling with obesity or weight-related health issues. As an appetite suppressant, phentermine works by stimulating the central nervous system, which helps reduce hunger and increase energy levels. This makes it easier for users to follow a calorie-restricted diet and adopt healthier eating habits. Phentermine tablets are typically used short-term and are most effective when combined with lifestyle changes like improved diet and increased physical activity.

These tablets are available in various strengths, commonly ranging from 8 mg to 37.5 mg, and are usually taken once a day before breakfast or 1 to 2 hours after. The dosage depends on individual factors such as weight, response to the medication, and the presence of any other medical conditions. Brand names for phentermine tablets include Adipex-P and Lomaira. While effective, users may experience side effects such as dry mouth, insomnia, dizziness, or elevated heart rate, so regular monitoring by a healthcare provider is important.

Phentermine tablets are not intended for long-term use due to the risk of dependence and potential cardiovascular side effects. They serve as a jumpstart to weight loss, helping users build momentum toward healthier habits. For best results, phentermine should be part of a comprehensive weight management plan that includes regular exercise, nutritious meals, and behavioral support. As with any medication, it’s crucial to use phentermine under medical supervision to ensure safety and maximize its benefits.

Phentermine and Depression

Phentermine is a prescription medication commonly used as an appetite suppressant to aid weight loss in individuals with obesity. It works by stimulating the central nervous system, which increases heart rate and energy levels while decreasing appetite. While it can be effective for short-term weight management, phentermine is a stimulant similar to amphetamines and may influence mood and mental health in some users.

There have been reports of phentermine both improving and worsening symptoms of depression. For some individuals, the weight loss and increased energy brought on by the medication may lead to an improved mood and better self-esteem. However, for others, especially those with a history of mental health issues, phentermine may exacerbate symptoms of anxiety, irritability, or depression due to its stimulating effects and potential to disrupt sleep, particularly if not paired with a balanced diet and structured exercise program.

Because phentermine can affect neurotransmitter levels, it’s important for users with existing mood disorders to approach it with caution and consult their healthcare provider. Combining phentermine with certain antidepressants, particularly MAO inhibitors or SSRIs, can also lead to serious interactions. Monitoring mental health during phentermine use is essential, and any changes in mood or behavior should be reported to a medical professional promptly.

Phentermine Efficacy

Phentermine has proven to be an effective short-term aid in weight loss, particularly when combined with a reduced-calorie diet, regular physical activity, and behavioral changes. As a sympathomimetic amine, it works by suppressing appetite through the central nervous system, helping users reduce caloric intake. Clinical studies have shown that individuals using phentermine often experience greater weight loss over a few weeks compared to those relying on lifestyle changes alone.

The efficacy of phentermine is typically most noticeable during the initial 12-week treatment period. During this time, users may lose an average of 5% to 10% of their starting body weight, depending on dosage, adherence to dietary recommendations, and individual metabolic differences. The rapid weight reduction can also help improve obesity-related conditions like type 2 diabetes, hypertension, and high cholesterol, making phentermine a valuable tool in medical weight management.

However, phentermine’s long-term efficacy is limited due to its potential for tolerance and side effects. Over time, the appetite-suppressing effects may diminish, and prolonged use increases the risk of dependency or cardiovascular issues. Therefore, healthcare providers typically recommend using phentermine only for short durations, emphasizing the importance of long-term lifestyle changes to sustain weight loss after the medication is discontinued.

Phentermine Liquid

Phentermine liquid is an alternative form of the popular weight loss medication, designed for individuals who may have difficulty swallowing pills or prefer a liquid formulation. Like its tablet and capsule counterparts, liquid phentermine acts as an appetite suppressant by stimulating the central nervous system. This stimulation increases heart rate and energy expenditure while reducing hunger, which can help users maintain a calorie deficit for effective weight loss; however, some users may experience side effects such as feet trouble due to circulation changes or increased physical activity.

The liquid form is usually administered once daily, often in the morning to minimize the risk of insomnia, a common side effect. Dosage can be more easily adjusted with liquid phentermine, offering flexibility for those who may need lower or more precise amounts. It is typically prescribed for short-term use, as part of a broader weight management plan that includes dietary modifications, exercise, and behavioral strategies to support long-term results.

As with other forms of phentermine, the liquid version may cause side effects such as dry mouth, insomnia, increased heart rate, or nervousness. It should be used under the supervision of a healthcare provider, especially in individuals with pre-existing conditions like heart disease or high blood pressure. Although some weight loss aids are available over the counter, phentermine is a prescription medication and should not be confused with over the counter alternatives. While effective for jumpstarting weight loss, liquid phentermine is most successful when used alongside sustainable lifestyle changes rather than as a standalone solution.

Phentermine Diet Pills

Phentermine diet pills are a widely prescribed medication for short-term weight loss, primarily used in individuals with obesity or weight-related health conditions. As an appetite suppressant, phentermine stimulates the central nervous system, increasing energy levels and decreasing hunger signals. However, in rare cases, its stimulating effects may increase the risk of serious cardiovascular events such as a heart attack. This helps users reduce their calorie intake more effectively, making it easier to stick to a low-calorie diet and initiate weight loss.

These diet pills are most commonly prescribed as part of a medically supervised weight loss program that includes a healthy diet, regular physical activity, and behavior modification strategies. While phentermine can significantly aid in reducing body weight, it is not a miracle pill. Its effectiveness relies heavily on the user’s commitment to adopting healthier habits and maintaining them even after the medication course ends.

Although phentermine diet pills are generally considered safe when taken as directed, they can cause side effects such as dry mouth, insomnia, elevated blood pressure, and increased heart rate. They are typically prescribed for a limited duration—usually a few weeks—to jumpstart weight loss. For long-term success, healthcare providers often emphasize the importance of using phentermine as a tool to build lasting lifestyle changes rather than relying on it as a permanent solution, unless a doctor tells you otherwise.

Phentermine Interactions

Phentermine, while effective for short-term weight loss, can interact with various medications and substances, potentially altering its effects or increasing the risk of adverse reactions. One of the most critical interactions is with monoamine oxidase inhibitors (MAOIs); combining these can lead to dangerously high blood pressure and other serious cardiovascular issues, including a rapid spike in high blood pressure that can be life-threatening. In some cases, such interactions may also contribute to decreased interest in daily activities or overall well-being. For this reason, phentermine should not be taken within 14 days of using an MAOI.

Additionally, phentermine may interact with other medications used for weight loss or depression, such as SSRIs, SNRIs, or bupropion. These combinations can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by confusion, rapid heart rate, and muscle rigidity. It may also amplify stimulant effects when taken with other drugs that affect the central nervous system, leading to jitteriness, anxiety, or heart palpitations.

Patients with chronic conditions like hypertension, diabetes, or thyroid disorders must be especially cautious, as phentermine can affect blood pressure, blood sugar levels, metabolism, and may contribute to symptoms such as walking weakness. It’s essential to inform healthcare providers about all current medications, supplements, and underlying health issues before starting phentermine to ensure safe use and avoid harmful drug interactions that could compromise blood sugar control or the effectiveness of treatment.

Phentermine Dosage

Phentermine dosage varies depending on the specific formulation, patient needs, and medical guidance. It is typically prescribed in strengths ranging from 8 mg to 37.5 mg, with options available as tablets, capsules, or orally disintegrating tablets. The most common dosage is 37.5 mg once daily, usually taken in the morning to avoid sleep disturbances. Some formulations may be divided into smaller doses throughout the day, especially in patients sensitive to stimulants.

The appropriate dosage of phentermine is determined by the patient’s weight loss goals, health status, and how well they tolerate the medication. Physicians often start with a lower dose to assess side effects and gradually adjust based on the patient’s response. It’s important to follow dosing instructions closely, as exceeding the recommended amount can increase the risk of side effects such as insomnia, elevated blood pressure, or dependence, and may also result in changes in performance increased interest.

Because phentermine is intended for short-term use, usually for a few weeks, dosage should not be continued long-term without careful medical supervision. Abrupt discontinuation after prolonged use may lead to withdrawal symptoms, so dosage tapering might be necessary to avoid the following symptoms. Regular follow-ups with a healthcare provider help monitor effectiveness and ensure that the prescribed dosage remains safe and suitable throughout the treatment period.

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FAQ

Can I take a laxative with phentermine?

You should consult your doctor before combining phentermine, a controlled substance, with a laxative, as it may increase side effects and risks associated with using a controlled substance.

Is phentermine prescription needed?

Yes, phentermine requires a doctor’s prescription, especially because it can be dangerous for individuals with uncontrolled high blood pressure, and doctors must carefully evaluate patients for conditions like uncontrolled high blood pressure before prescribing it.

What does the drug phentermine do?

Phentermine suppresses appetite to help with weight loss, and understanding how the medication affects the body is important for safe and effective use.

What is the strongest weight loss prescription pill?

Phentermine-topiramate (Qsymia) is considered one of the most effective prescription weight loss pills, but it’s important to follow the prescription label carefully for safe use.

What does phentermine do to your system?

It stimulates the central nervous system to reduce hunger and increase energy expenditure, but if you have a missed dose, follow your doctor’s instructions on how to proceed.

How much weight can you lose with phentermine?

Average weight loss is around 5% to 10% of initial body weight over 12 weeks, but it’s important to stop use and seek medical help if signs of an allergic reaction occur. Symptoms of an allergic reaction may include rash, itching, swelling, severe dizziness, or trouble breathing.

Do doctors still prescribe phentermine for weight loss?

Yes, doctors still prescribe it short-term for weight loss, and it’s important to note that phentermine may also affect blood sugar levels, particularly in people with diabetes.

Is phentermine a safe weight loss drug?

It can be safe for short-term use under medical supervision but has potential risks and side effects, especially for individuals with an overactive thyroid. People with an overactive thyroid should avoid using phentermine due to the increased risk of serious cardiovascular complications.

What are the major side effects of phentermine?

Major side effects include increased heart rate, insomnia, dry mouth, anxiety, and chest pain. If you experience chest pain while taking phentermine, you should seek immediate medical attention. Persistent chest pain could indicate a serious cardiovascular issue that requires prompt evaluation by a healthcare provider.

What do phentermine pills do to your body?

They increase energy and reduce appetite, helping with calorie reduction and weight loss, and belong to a class of medications called anorectics.

How fast will I lose weight on phentermine?

Weight loss can begin within the first week, depending on diet and lifestyle; if you experience any unusual symptoms, contact your doctor immediately.

What kind of narcotic is phentermine?

Phentermine is not a narcotic but a stimulant similar to amphetamines. It may interact with other medicines, so it’s important to inform your doctor about any other medicines you’re taking. Additionally, combining phentermine with other medicines that affect the central nervous system could increase the risk of side effects. Always consult your healthcare provider before using phentermine alongside other medicines.

What do phentermine pills do?

They help suppress appetite and increase energy to support weight loss, but individuals with coronary artery disease should avoid using these medications without medical supervision.

What happens after 3 months of phentermine?

Effects may lessen due to tolerance, and doctors may recommend stopping or switching treatments, especially if there are concerns about conditions like heart valve disease.

How much weight do you lose with phentermine?

Most people lose about 10 to 20 pounds in 12 weeks with proper diet and exercise, but drinking alcohol can interfere with weight loss efforts. Additionally, drinking alcohol while using weight loss medications may increase the risk of side effects.

How safe is phentermine for weight loss?

It is generally safe short-term when prescribed by a healthcare provider, but long-term use is not recommended due to potential side effects and decreased ability to maintain weight loss without medication.

Will a doctor prescribe phentermine?

Yes, if you meet the criteria for weight loss treatment, but it’s important to discuss with your doctor how phentermine might interact with birth control, as some medications can affect the effectiveness of birth control.

How much weight did you lose in 3 months on phentermine?

Weight loss varies but can range from 10 to 20 pounds or more in 3 months, though individuals with kidney disease should consult their doctor before using phentermine.

Is phentermine 37.5 a prescription?

Yes, phentermine 37.5 mg is a prescription-only medication, and some individuals may experience sexual intercourse difficulty as a potential side effect.

Will phentermine cause depression?

In some people, phentermine may contribute to mood changes or depressive symptoms, and those with a history of valvular heart disease should use it with caution under medical supervision.

Is phentermine a stimulant or depressant?

Phentermine is a central nervous system stimulant, and how the medicine affects each individual can vary depending on their overall health and concurrent medications.

Does phentermine affect serotonin levels?

Phentermine primarily affects norepinephrine but may have minor effects on serotonin, and it can lead to trouble sleeping, especially if taken late in the day; trouble sleeping is a common side effect reported by users.

Does phentermine get you in a good mood?

It can initially improve mood and energy, though some may experience irritability or anxiety, and in some cases, it may cause an irregular heartbeat.

What is the success rate of phentermine?

Success rates vary, but many users experience meaningful weight loss within a few months when using this prescription medicine.

What are three common side effects?

Phentermine is a stimulant that suppresses appetite and boosts energy; to answer the question “how does phentermine work”—it primarily stimulates the release of norepinephrine in the brain, which reduces hunger signals.

What to avoid when taking phentermine?

Avoid alcohol, other stimulants, and high-fat or high-sugar foods, as combining these with phentermine may increase the risk of severe mental changes.

Is phentermine hard on your heart?

It can increase heart rate and blood pressure, so it’s not recommended for people with heart conditions, especially since phentermine interact with certain medications can further raise cardiovascular risk.

Can phentermine tablets be crushed?

No, crushing phentermine tablets is not recommended unless directed by a doctor, as the medication is habit forming and altering its form can increase the risk of misuse or side effects.

What can I combine with phentermine to lose weight?

A balanced diet, regular exercise, and behavioral changes enhance phentermine’s effects, but it should not be used during pregnancy due to potential risks to the unborn baby.

Do you swallow phentermine or let it dissolve?

It depends on the formulation; tablets are usually swallowed, while orally disintegrating versions dissolve, both designed to help speed weight loss when used with diet and exercise.

Is phentermine 37.5 extended-release?

No, phentermine 37.5 mg is typically an immediate-release tablet and should not be taken with certain following medications without consulting a healthcare provider.

What does phentermine do for your body?

It reduces hunger and boosts energy to support weight loss, but it should only be used under the supervision of a health care professional. Always consult a health care professional before starting or adjusting phentermine treatment.

Is phentermine the same as Adderall?

No, but both are stimulants; phentermine is for weight loss, Adderall is for ADHD, and phentermine may sometimes cause an unpleasant taste as a side effect.

Is phentermine used for anything else besides weight loss?

It is primarily used for weight loss, with few off-label uses, and it’s important to store phentermine at room temperature away from moisture and heat.

How much weight can you lose taking phentermine?

Users can typically lose 5%–10% of body weight over 12 weeks, depending on the dosage forms prescribed and adherence to lifestyle changes; various dosage forms are available to suit individual treatment needs.

What should you not mix with phentermine?

Avoid MAO inhibitors, alcohol, and other stimulants, as combining these with phentermine may increase the risk of side effects such as skin rash.

What people should not take phentermine?

People with heart disease, hyperthyroidism, glaucoma, or a history of drug abuse should avoid it, as it may also lead to side effects such as legs swelling in some individuals.

Can you drink caffeine while on phentermine?

Caffeine should be limited, as it can worsen side effects like jitteriness and insomnia, and may also affect your bowel movement patterns.

What disqualifies you from taking phentermine?

Conditions like uncontrolled hypertension, cardiovascular disease, or drug abuse history may disqualify you, and you may also experience an unusual sense of discomfort or side effects when using phentermine.

How does phentermine make you lose weight so fast?

It suppresses appetite and increases energy expenditure, leading to reduced calorie intake and potentially lowering the risk of conditions like kidney stones.

What not to do while on phentermine?

Avoid skipping meals, overexerting yourself, or mixing with alcohol or stimulants, as these can interfere with appetite suppression.

Why can you only take phentermine for 3 months?

It’s approved only for short-term use due to risk of dependence and tolerance, and some users may experience side effects such as lower legs trembling.

How quickly does phentermine start working?

Phentermine usually begins working within a few hours of the first dose and may, in some cases, affect sexual ability.

Reference

  1. Chugh PK, Sharma S. Recent advances in the pathophysiology and pharmacological treatment of obesity. J Clin Pharm Ther. 2012;37(5):525-35.

  2. Li Z, Maglione M, Tu W, et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med. 2005;142(7):532-46.

  3. Uwaifo GI, Melcescu E, Mcdonald A, Koch CA. A case of profound weight loss secondary to use of phentermine. J Miss State Med Assoc. 2009;50(12):407-15.

  4. Smith SM, Meyer M, Trinkley KE. Phentermine/topiramate for the treatment of obesity. Ann Pharmacother. 2013;47(3):340-9.

  5. Cosentino G, Conrad AO, Uwaifo GI. Phentermine and topiramate for the management of obesity: a review. Drug Des DevelTher. 2011;7:267–278. Published 2011 Apr 5. doi:10.2147/DDDT.S31443.

  6. Atkinson RL, Blank RC, Schumacher D, Dhurandhar NV, Ritch DL. Long-term drug treatment of obesity in a private practice setting. Obes Res. 1997 Nov;5(6):578–586.

  7. Spitz AF, Schumacher D, Blank RC, Dhurandhar NV, Atkinson RL. Long-term pharmacologic treatment of morbid obesity in a community practice. EndocrPract. 1997 Sep-Oct;3(5):269–275.

  8. Astrup A, Breum L, Toubro S, Hein P, Quaade F. The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial. Int J ObesRelatMetabDisord. 1992 Apr;16(4):269–277.

  9. Weintraub M, Sundaresan PR, Schuster B, et al. Long-term weight control study. II (weeks 34 to 104). An open-label study of continuous fenfluramine plus phentermine versus targeted intermittent medication as adjuncts to behavior modification, caloric restriction, and exercise. ClinPharmacolTher. 1992 May;51(5):595–601.

  10. Weintraub M, Sundaresan PR, Madan M, et al. Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo. ClinPharmacolTher. 1992 May;51(5):586–594.

  11. Astrup A, Toubro S, Cannon S, Hein P, Madsen J. Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study. Metabolism. 1991 Mar;40(3):323–329.

  12. Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011 Apr 16;377(9774):1341–1352.

  13. Garvey WT, Ryan DH, Look M, et al. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J ClinNutr. 2012 Feb;95(2):297–308.

  14. Allison DB, Gadde KM, Garvey WT, et al. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP) Obesity (Silver Spring) 2012 Feb;20(2):330–342.

  15. Munro JF, MacCuish AC, Wilson EM, Duncan LJ. Comparison of continuous and intermittent anorectic therapy in obesity. Br Med J. 1968 Feb 10;1(5588):352–354.

  16. Bray GA. Drug insight: appetite suppressants. Nat ClinPractGastroenterolHepatol. 2005 Feb;2(2):89–95.

  17. Makoundou V, Golay A. Drug control of appetite. Rev Med Suisse. 2011 Jan 12;7(277):57–60.

  18. Munro JF, MacCuish AC, Wilson EM, Duncan LJ. Comparison of continuous and intermittent anorectic therapy in obesity. Br Med J. 1968 Feb 10;1(5588):352–354.

  19. Phentermine: an appetite-suppressant amphetamine classified as a narcotic in France. Is a combination with topiramate on the horizon? Prescrire Int. Sep;21(130):209.

  20. Bray GA. Drug insight: appetite suppressants. Nat ClinPractGastroenterolHepatol. 2005 Feb;2(2):89–95.

  21. Hendricks EJ, Rothman RB, Greenway FL. How physician obesity specialists use drugs to treat obesity. Obesity (Silver Spring) 2009 Sep;17(9):1730–1735.

  22. Spitz AF, Schumacher D, Blank RC, Dhurandhar NV, Atkinson RL. Long-term pharmacologic treatment of morbid obesity in a community practice. EndocrPract. 1997 Sep-Oct;3(5):269–275.

  23. Cosentino G, Conrad AO, Uwaifo GI. Phentermine and topiramate for the management of obesity: a review. Drug Des DevelTher. 2011;7:267–278. Published 2011 Apr 5. doi:10.2147/DDDT.S31443.

  24. Singh J, Kumar R. Phentermine-topiramate: First combination drug for obesity. Int J Appl Basic Med Res. 2015;5(2):157–158. doi:10.4103/2229-516X.157177.

  25. Malgarini RB, Pimpinella G. Phentermine plus topiramate in the treatment of obesity. Lancet. 2011;378(9786):125-6.

  26. Cameron F, Whiteside G, Mckeage K. Phentermine and topiramate extended release (Qsymia™): first global approval. Drugs. 2012;72(15):2033-42.

  27. Bays H. Phentermine, topiramate and their combination for the treatment of adiposopathy (‘sick fat’) and metabolic disease. Expert Rev CardiovascTher. 2010;8(12):1777-801.

  28. Bays HE, Gadde KM. Phentermine/topiramate for weight reduction and treatment of adverse metabolic consequences in obesity. Drugs Today. 2011;47(12):903-14.

  29. Bays HE, Gadde KM. Phentermine/topiramate for weight reduction and treatment of adverse metabolic consequences in obesity. Drugs Today. 2011;47(12):903-14.

  30. Halford JC, Boyland EJ, Blundell JE, Kirkham TC, Harrold JA. Pharmacological management of appetite expression in obesity. Nat Rev Endocrinol. 2010;6(5):255–269.

  31. Greenway FL, Fujioka K, Plodkowski RA, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376(9741):595–605.

  32. Rebello CJ, Greenway FL. Reward-induced eating: therapeutic approaches to addressing food cravings. AdvTher. 2016;33(11):1853–1866.

  33. Thomas EA, Mcnair B, Bechtell JL, Ferland A, Cornier MA, Eckel RH. Greater hunger and less restraint predict weight loss success with phentermine treatment. Obesity (Silver Spring) 2016;24(1):37–43.

  34. Hendricks EJ, Greenway FL, Westman EC, Gupta AK. Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring) 2011;19(12):2351–2360.

  35. Lorber J. Obesity in childhood. A controlled trial of anorectic drugs. Arch Dis Child. 1966;41(217):309–312.

  36. Hendricks EJ, Srisurapanont M, Schmidt SL, et al. Addiction potential of phentermine prescribed during long-term treatment of obesity. Int J Obes (Lond) 2014;38(2):292–298.

  37. Haddock CK, Poston WS, Dill PL, Foreyt JP, Ericsson M. Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J ObesRelatMetabDisord. 2002;26(2):262–273.

  38. Kim KK, Cho HJ, Kang HC, Youn BB, Lee KR. Effects on weight reduction and safety of short-term phentermine administration in Korean obese people. Yonsei Med J. 2006;47(5):614–625. doi:10.3349/ymj.2006.47.5.614.

  39. Available from https://www.healio.com/endocrinology/news/online/%7B09077204-6c34-4b89-bd75-98e9489deb84%7D/dramatic-weight-loss-benefits-with-combination-phentermine-topiramate.

  40. Hendricks EJ, Greenway FL, Westman EC, Gupta AK. Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring). 2011;19(12):2351-60.

  41. Torgerson JS, Sjöström L. The Swedish Obese Subjects (SOS) study–rationale and results. Int J ObesRelatMetabDisord. 2001;25Suppl 1:S2-4.

  42. Wing RR, Lang W, Wadden TA, et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011;34(7):1481-6.

  43. Vallé-jones JC, Brodie NH, O’hara H, O’hara J, Mcghie RL. A comparative study of phentermine and diethylpropion in the treatment of obese patients in general practice. Pharmatherapeutica. 1983;3(5):300-4.

  44. Davidson MH, Tonstad S, Oparil S, Schwiers M, Day WW, Bowden CH. Changes in cardiovascular risk associated with phentermine and topiramate extended-release in participants with comorbidities and a body mass index ≥27 kg/m(2). Am J Cardiol. 2013;111(8):1131-8.

  45. Simonds SE, Pryor JT, Koegler FH, et al. Determining the Effects of Combined Liraglutide and Phentermine on Metabolic Parameters, Blood Pressure, and Heart Rate in Lean and Obese Male Mice. Diabetes. 2019;68(4):683-695.

  46. Ritchey ME, Harding A, Hunter S, et al. Cardiovascular Safety During and After Use of Phentermine and Topiramate. J ClinEndocrinolMetab. 2019;104(2):513-522.

  47. Jordan J, Astrup A, Engeli S, Narkiewicz K, Day WW, Finer N. Cardiovascular effects of phentermine and topiramate: a new drug combination for the treatment of obesity. J Hypertens. 2014;32(6):1178–1188. doi:10.1097/HJH.0000000000000145.

  48. Davidson MH, Tonstad S, Oparil S, Schwiers M, Day WW, Bowden CH. Changes in cardiovascular risk associated with phentermine and topiramate extended-release in participants with comorbidities and a body mass index ≥27 kg/m2. Am J Cardiol 2013; 111:1131–1138.

  49. Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, Day WW. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet 2011; 377:1341–1352.

  50. Caterson ID, Finer N, Coutinho W, et al. Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial. Diabetes ObesMetab. 2012;14(6):523-30.

  51. Winslow DH, Bowden CH, Didonato KP, Mccullough PA. A randomized, double-blind, placebo-controlled study of an oral, extended-release formulation of phentermine/topiramate for the treatment of obstructive sleep apnea in obese adults. Sleep. 2012;35(11):1529-39.

  52. Available from https://www.prnewswire.com/news-releases/study-finds-significant-improvements-in-patients-with-obstructive-sleep-apnea-treated-with-phentermine-and-topiramate-extended-release-capsules-178843691.html.

  53. 53.  Available from https://journals.lww.com/ebp/Abstract/2018/04000/Does_phentermine_improve_cardiovascular_outcomes.24.aspx.

  54. Kiortsis DN. A review of the metabolic effects of controlled-release Phentermine/Topiramate. Hormones (Athens). 2013;12(4):507-16.

  55. Davidson MH, Tonstad S, Oparil S, Schwiers M, Day WW, Bowden CH. Changes in cardiovascular risk associated with phentermine and topiramate extended-release in participants with comorbidities and a body mass index ≥27 kg/m2. Am J Cardiol 2013; 111:1131–1138.

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