Does RAD 150 increase muscle mass?

RAD-150 treatment can also help improve body composition by increasing muscle mass and strength: In mice models, SARMs administration resulted in increased muscle mass. In patients with severe diseases (cancer, AIDS, and multiple sclerosis) that cause muscle wasting, RAD-150 treatment increased bone and muscle cell growth. In bodybuilders, RAD-150 administration increased muscle mass, decreased fat tissue, and improved stamina and endurance during high-intensity interval training. In animals, RAD-150 administration appears to increase lean muscle mass.

Does RAD 150 Bone Strength?

RAD-150, a highly effective SARMs, has been shown to strengthen the bone structures by aiding in bone formation: A review of multiple studies showed that SARMs like RAD-150 can stimulate bone growth. In aged male rats with osteoporosis, SARMs therapy resulted in improved bone healing. In rats, SARMs significantly improved bone health by promoting bone formation, strength, and mass. In rats, SARMs were successful in preventing bone loss and promoting bone formation. In rats who had surgical removal of the testicles, SARMs administration caused a significant increase in bone mass density (BMD).

How does RAD 150 improve sexual dysfunction?

RAD-150 has also been shown to address sexual dysfunction due to various causes: A review of studies showed that SARMs administration is a possible treatment for sexual dysfunction due to hypogonadism (low testosterone). In a castrated rodent model, SARMs treatment resulted in amelioration of sexual dysfunction and motor activity deficits. In rats who had surgical removal of the ovaries, SARMs increased sexual motivation, with potency and efficacy comparable with testosterone propionate.

How does RAD 150 help to treat cancer?

Evidence suggests that RAD-150 and other SARMs have anti-cancer properties: A review of studies showed that SARMs inhibited breast cancer growth. In patients with breast cancer, RAD-150 treatment suppresses the growth of cancer cells by blocking the effects of estrogen on tissues. RAD-150 prevented the production of a protein called estrogen receptor 1 (ESR1), which is known to fuel cancer growth.

RAD-150 | TLB-150 Benzoate | Improves Muscle Mass

Q: Overall Health Benefits of RAD-150

Improves muscle mass and strength. Maintains bone strength and quality. Improves sexual function. Improves urinary health. Lowers the risk of cancer.

RAD-150

RAD-150, also known as TLB-150 Benzoate, is a remarkable compound which stabilizes the levels of testosterone. It works by mimicking the role of natural testosterone in your body. Because of esterification, a chemical reaction that forms at least one type of compound called ester (byproduct of acid and alcohol reaction), RAD-150 can last much longer in your body than its parent compound RAD-140 (about twice as long). Due to its high absorption rate, stability, and half-life of 48 hours, it offers a broad range of health benefits with little to no side effects and is significantly more effective than other selective androgen receptor modulators (SARMs).

Overall Health Benefits of RAD-150

Improves muscle mass and strength [1-4]
Maintains bone strength and quality [5-9]
Improves sexual function [10-12]
Improves urinary health [13-17]
Lowers the risk of cancer [18-21]

Proven Health Benefits by RAD-150

RAD-150 – Improves Muscle Mass and Strength

RAD-150 treatment can also help improve body composition by increasing muscle mass and strength:

In mice models, SARMs administration resulted in increased muscle mass. [1]
In patients with severe diseases (cancer, AIDS, and multiple sclerosis) that cause muscle wasting, RAD-150 treatment increased bone and muscle cell growth. [2]
In bodybuilders, RAD-150 administration increased muscle mass, decreased fat tissue, and improved stamina and endurance during high-intensity interval training. [3]
In animals, RAD-150 administration appears to increase lean muscle mass. [4]

Maintains Bone Strength and Quality

RAD-150, a highly effective SARMs, has been shown to strengthen the bone structures by aiding in bone formation:

A review of multiple studies showed that SARMs like RAD-150 can stimulate bone growth. [5]
In aged male rats with osteoporosis, SARMs therapy resulted in improved bone healing. [6]
In rats, SARMs significantly improved bone health by promoting bone formation, strength, and mass. [7]
In rats, SARMs were successful in preventing bone loss and promoting bone formation. [8]
In rats who had surgical removal of the testicles, SARMs administration caused a significant increase in bone mass density (BMD). [9]

Improves Sexual Function

RAD-150 has also been shown to address sexual dysfunction due to various causes:

A review of studies showed that SARMs administration is a possible treatment for sexual dysfunction due to hypogonadism (low testosterone). [10]
In a castrated rodent model, SARMs treatment resulted in amelioration of sexual dysfunction and motor activity deficits. [11]
In rats who had surgical removal of the ovaries, SARMs increased sexual motivation, with potency and efficacy comparable with testosterone propionate. [12]

Improves Urinary Health

The use of RAD-150 appears to reduce the prevalence of urinary tract infections and treat other urinary problems:

In mice who had surgical removal of the ovaries, SARMs decreased symptoms associated with stress urinary incontinence (SUI). [13]
In rats with impaired urethral continence function, SARMs administration enhanced the muscle function of the urethra. [14]
In mice with SUI, SARMs improved urinary function by increasing pelvic floor muscle mass. [15]
SARMs at varying doses (5, 10, and 25 mg/kg) decreased urinary symptoms associated with benign prostatic hyperplasia. [16]
Repeated treatment with SARMs appears to decrease prostate weight. [17]

Lowers the Risk of Cancer

Evidence suggests that RAD-150 and other SARMs have anti-cancer properties:

A review of studies showed that SARMs inhibited breast cancer growth. [18]
In patients with breast cancer, RAD-150 treatment suppresses growth of cancer cells by blocking the effects of estrogen on tissues. [19-20]
RAD-150 prevented the production of a protein called estrogen receptor 1 (ESR1), which is known to fuel cancer growth. [21]

References:

Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12(3):232-240. doi:10.1097/MCO.0b013e32832a3d79.
Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013). Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Current opinion in supportive and palliative care, 7(4), 345–351. https://doi.org/10.1097/SPC.0000000000000015.
Bhasin S, Jasuja R. Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies. Current opinion in clinical nutrition and metabolic care. 2009;12(3):232-240. doi:10.1097/MCO.0b013e32832a3d79. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/.
Geyer H, Schänzer W, Thevis M. Anabolic agents: recent strategies for their detection and protection from inadvertent doping. British Journal of Sports Medicine. 2014;48(10):820-826. doi:10.1136/bjsports-2014-093526. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033149/.
Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019;7(1):84-94. doi:10.1016/j.sxmr.2018.09.006.
Komrakova M, Nagel J, Hoffmann DB, Lehmann W, Schilling AF, Sehmisch S. Effect of Selective Androgen Receptor Modulator Enobosarm on Bone Healing in a Rat Model for Aged Male Osteoporosis. Calcif Tissue Int. 2020;107(6):593-602. doi:10.1007/s00223-020-00751-x.
Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005;5(3):173-188. doi:10.1124/mi.5.3.7.
Rosen J, Negro-Vilar A. Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile. J Musculoskelet Neuronal Interact. 2002 Mar;2(3):222-4. PMID: 15758439.
Gao W, Reiser PJ, Coss CC, et al. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146(11):4887-4897. doi:10.1210/en.2005-0572.
Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02.
Morimoto, M., Amano, Y., Oka, M., Harada, A., Fujita, H., Hikichi, Y., Tozawa, R., Yamaoka, M., & Hara, T. (2017). Amelioration of sexual behavior and motor activity deficits in a castrated rodent model with a selective androgen receptor modulator SARM-2f. PloS one, 12(12), e0189480. https://doi.org/10.1371/journal.pone.0189480.
Jones A, Hwang DJ, Duke CB 3rd, et al. Nonsteroidal selective androgen receptor modulators enhance female sexual motivation. J Pharmacol Exp Ther. 2010;334(2):439-448. doi:10.1124/jpet.110.168880.
Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Medicinal Chemistry Letters. 2011;2(2):124-129. doi:10.1021/ml1002508. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/.
Kadekawa, K., Kawamorita, N., Shimizu, T., Kurobe, M., Turnbull, P. S., Chandra, S., Kambara, T., Barton, J. C., Russell, A. J., & Yoshimura, N. (2020). Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. BJU international, 125(6), 911–919. https://doi.org/10.1111/bju.15022.
Ponnusamy, S., Sullivan, R. D., Thiyagarajan, T., Tillmann, H., Getzenberg, R. H., & Narayanan, R. (2017). Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice. Journal of cellular biochemistry, 118(3), 640–646. https://doi.org/10.1002/jcb.25751.
Omwancha J, Brown TR. Selective androgen receptor modulators: in pursuit of tissue-selective androgens. Current opinion in investigational drugs (London, England : 2000). 2006; 7(10):873-81. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17086931.
Nejishima H, Yamamoto N, Suzuki M, Furuya K, Nagata N, Yamada S. Anti-androgenic effects of S-40542, a novel non-steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia. The Prostate. 2012; 72(14):1580-7. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22430536.
Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02.
Yu Z, He S, Wang D. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017; 23(24):7608-7620. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28974548.
Ziyang Yu, Suqin He, Jeffrey Brown, Chris Miller, Jamal Saeh, Gary Hattersley. RAD140, an orally available selective androgen receptor modulator, inhibits the growth of AR/ER positive breast cancer cell line- and patient-derived xenograft models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3608. doi:10.1158/1538-7445.AM2017-3608. Retrieved from http://cancerres.aacrjournals.org/content/77/13_Supplement/3608.
Yu Z, He S, Wang D. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017; 23(24):7608-7620. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28974548.

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RAD-150

Overall Health Benefits of RAD-150

Proven Health Benefits by RAD-150