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RAD-150

Author: Dr. George Shanlikian, M.D.  |   Last Updated: December 16th, 2023

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RAD-150

RAD-150, also known as TLB-150 Benzoate, is a remarkable compound which stabilizes the levels of testosterone. It works by mimicking the role of natural testosterone in your body. Because of esterification, a chemical reaction that forms at least one type of compound called ester (byproduct of acid and alcohol reaction), RAD-150 can last much longer in your body than its parent compound RAD-140 (about twice as long). Due to its high absorption rate, stability, and half-life of 48 hours, it offers a broad range of health benefits with little to no side effects and is significantly more effective than other selective androgen receptor modulators (SARMs).

Overall Health Benefits of RAD-150

  • Improves muscle mass and strength [1-4]
  • Maintains bone strength and quality [5-9]
  • Improves sexual function [10-12]
  • Improves urinary health [13-17]
  • Lowers the risk of cancer [18-21]

Proven Health Benefits by RAD-150

RAD-150 – Improves Muscle Mass and Strength

RAD-150 for Muscle Mass and Strength
RAD-150 for Muscle Mass and Strength

RAD-150 treatment can also help improve body composition by increasing muscle mass and strength:

  1. In mice models, SARMs administration resulted in increased muscle mass. [1]
  2. In patients with severe diseases (cancer, AIDS, and multiple sclerosis) that cause muscle wasting, RAD-150 treatment increased bone and muscle cell growth. [2]
  3. In bodybuilders, RAD-150 administration increased muscle mass, decreased fat tissue, and improved stamina and endurance during high-intensity interval training. [3]
  4. In animals, RAD-150 administration appears to increase lean muscle mass. [4]

Maintains Bone Strength and Quality

RAD-150, a highly effective SARMs, has been shown to strengthen the bone structures by aiding in bone formation:

  1. A review of multiple studies showed that SARMs like RAD-150 can stimulate bone growth. [5]
  2. In aged male rats with osteoporosis, SARMs therapy resulted in improved bone healing. [6]
  3. In rats, SARMs significantly improved bone health by promoting bone formation, strength, and mass. [7]
  4. In rats, SARMs were successful in preventing bone loss and promoting bone formation. [8]
  5. In rats who had surgical removal of the testicles, SARMs administration caused a significant increase in bone mass density (BMD). [9]

Improves Sexual Function

RAD-150 for Improves Sexual Function
RAD-150 for Improves Sexual Function

RAD-150 has also been shown to address sexual dysfunction due to various causes:

  1. A review of studies showed that SARMs administration is a possible treatment for sexual dysfunction due to hypogonadism (low testosterone). [10]
  2. In a castrated rodent model, SARMs treatment resulted in amelioration of sexual dysfunction and motor activity deficits. [11]
  3. In rats who had surgical removal of the ovaries, SARMs increased sexual motivation, with potency and efficacy comparable with testosterone propionate. [12]

Improves Urinary Health

The use of RAD-150 appears to reduce the prevalence of urinary tract infections and treat other urinary problems:

  1. In mice who had surgical removal of the ovaries, SARMs decreased symptoms associated with stress urinary incontinence (SUI). [13]
  2. In rats with impaired urethral continence function, SARMs administration enhanced the muscle function of the urethra. [14]
  3. In mice with SUI, SARMs improved urinary function by increasing pelvic floor muscle mass. [15]
  4. SARMs at varying doses (5, 10, and 25 mg/kg) decreased urinary symptoms associated with benign prostatic hyperplasia. [16]
  5. Repeated treatment with SARMs appears to decrease prostate weight. [17]

Lowers the Risk of Cancer

Evidence suggests that RAD-150 and other SARMs have anti-cancer properties:

  1. A review of studies showed that SARMs inhibited breast cancer growth. [18]
  2. In patients with breast cancer, RAD-150 treatment suppresses growth of cancer cells by blocking the effects of estrogen on tissues. [19-20]
  3. RAD-150 prevented the production of a protein called estrogen receptor 1 (ESR1), which is known to fuel cancer growth. [21]

References:

  1. Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care. 2009;12(3):232-240. doi:10.1097/MCO.0b013e32832a3d79.
  2. Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013). Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Current opinion in supportive and palliative care, 7(4), 345ā€“351. https://doi.org/10.1097/SPC.0000000000000015.
  3. Bhasin S, Jasuja R. Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies. Current opinion in clinical nutrition and metabolic care. 2009;12(3):232-240. doi:10.1097/MCO.0b013e32832a3d79. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/.
  4. Geyer H, SchƤnzer W, Thevis M. Anabolic agents: recent strategies for their detection and protection from inadvertent doping. British Journal of Sports Medicine. 2014;48(10):820-826. doi:10.1136/bjsports-2014-093526. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033149/.
  5. Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019;7(1):84-94. doi:10.1016/j.sxmr.2018.09.006.
  6. Komrakova M, Nagel J, Hoffmann DB, Lehmann W, Schilling AF, Sehmisch S. Effect of Selective Androgen Receptor Modulator Enobosarm on Bone Healing in a Rat Model for Aged Male Osteoporosis. Calcif Tissue Int. 2020;107(6):593-602. doi:10.1007/s00223-020-00751-x.
  7. Chen J, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. Mol Interv. 2005;5(3):173-188. doi:10.1124/mi.5.3.7.
  8. Rosen J, Negro-Vilar A. Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile. J Musculoskelet Neuronal Interact. 2002 Mar;2(3):222-4. PMID: 15758439.
  9. Gao W, Reiser PJ, Coss CC, et al. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005;146(11):4887-4897. doi:10.1210/en.2005-0572.
  10. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02.
  11. Morimoto, M., Amano, Y., Oka, M., Harada, A., Fujita, H., Hikichi, Y., Tozawa, R., Yamaoka, M., & Hara, T. (2017). Amelioration of sexual behavior and motor activity deficits in a castrated rodent model with a selective androgen receptor modulator SARM-2f. PloS one, 12(12), e0189480. https://doi.org/10.1371/journal.pone.0189480.
  12. Jones A, Hwang DJ, Duke CB 3rd, et al. Nonsteroidal selective androgen receptor modulators enhance female sexual motivation. J Pharmacol Exp Ther. 2010;334(2):439-448. doi:10.1124/jpet.110.168880.
  13. Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Medicinal Chemistry Letters. 2011;2(2):124-129. doi:10.1021/ml1002508. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/.
  14. Kadekawa, K., Kawamorita, N., Shimizu, T., Kurobe, M., Turnbull, P. S., Chandra, S., Kambara, T., Barton, J. C., Russell, A. J., & Yoshimura, N. (2020). Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. BJU international, 125(6), 911ā€“919. https://doi.org/10.1111/bju.15022.
  15. Ponnusamy, S., Sullivan, R. D., Thiyagarajan, T., Tillmann, H., Getzenberg, R. H., & Narayanan, R. (2017). Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice. Journal of cellular biochemistry, 118(3), 640ā€“646. https://doi.org/10.1002/jcb.25751.
  16. Omwancha J, Brown TR. Selective androgen receptor modulators: in pursuit of tissue-selective androgens. Current opinion in investigational drugs (London, England : 2000). 2006; 7(10):873-81. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17086931.
  17. Nejishima H, Yamamoto N, Suzuki M, Furuya K, Nagata N, Yamada S. Anti-androgenic effects of S-40542, a novel non-steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia. The Prostate. 2012; 72(14):1580-7. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22430536.
  18. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02.
  19. Yu Z, He S, Wang D. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017; 23(24):7608-7620. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28974548.
  20. Ziyang Yu, Suqin He, Jeffrey Brown, Chris Miller, Jamal Saeh, Gary Hattersley. RAD140, an orally available selective androgen receptor modulator, inhibits the growth of AR/ER positive breast cancer cell line- and patient-derived xenograft models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3608. doi:10.1158/1538-7445.AM2017-3608. Retrieved from http://cancerres.aacrjournals.org/content/77/13_Supplement/3608.
  21. Yu Z, He S, Wang D. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clinical cancer research : an official journal of the American Association for Cancer Research. 2017; 23(24):7608-7620. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28974548.
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