Bremelanotide, also known as PT-141, is a powerful peptide (a compound consisting of two or more amino acids) that activates internal pathways in the brain involved in normal sexual responses. This FDA-approved drug is also a melanocortin receptor agonist, which helps activate a type of protein known as melanocortin receptors. It is given by subcutaneous injection (under the skin) using a single use autoinjector pen. Scientific studies report that the administration of this peptide has shown promise in various aspects of health.
As a melanocortin receptor agonist, bremelanotide helps activate a type of protein known as melanocortin receptors. These receptors are involved in wide range of brain activities such as sexual arousal, mood, appetite, and thinking.
Sexual dysfunction often affects one’s self-confidence and relationship with a partner. Fortunately, this condition is very treatable with bremelanotide. In fact, the FDA approved bremelanotide in June 2019 as a therapeutic option for women with low libido after it showed an increase in sexual desire and reduction in distress in two replicate phase 3 trials involving women with hypoactive sexual desire disorder (HSDD). [1-2] It now joins flibanserin, the only other drug approved by the FDA for the treatment of HSDD in premenopausal women.
Numerous human studies have also shown promising results with regards to the therapeutic benefits of bremelanotide on sexual health:
Studies show that the melanocortin receptor agonist bremelanotide may also help improve body composition by inducing weight loss:
There is increasing evidence that bremelanotide along with other melanocortin receptor agonists may help improve cognitive health. Studies show that they exert this effect through the following mechanisms:
Studies show that melanocortin receptor agonists help protect against diabetes and the negative effects of high blood sugar:
There is also evidence that melanocortin receptor agonists such as bremelanotide may help correct abnormal lipid levels:
In men and women with sexual dysfunction, low mood and depression are very common. Because of the therapeutic benefit of bremelanotide on libido and sexual performance, this powerful peptide has been studied for its mood-enhancing effect:
Photoreceptor cell, a specialized type of neuron found in the retina, is particularly vulnerable to high blood sugar levels. Studies show that melanocortin receptor agonists help preserve eye health:
Recent data have implicated that melanocortin receptor agonists such as bremelanotide may play a role in modulating voluntary ethanol (alcohol) consumption, thereby treating alcohol addiction:
Melanocortin receptor agonists such as bremelanotide play a crucial role in strengthening the immune system. Studies show that melanocortin receptor agonists exert their immune boosting effects through various mechanisms:
Bremelanotide side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on bremelanotide. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of bremelanotide. Despite this, it was listed as a side effect associated with bremelanotide even though these associated side effects are very uncommon.
Side effects associated with bremelanotide may include the following:
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