Melatonin

Overall Health Benefits

• Improves sleep quality [1-8]
• Lowers risk of cardiovascular disease [9-13]
• Prevents cancer [14-18]
• Promotes weight loss [19-23]
• Boosts immunity [22] [24-27]
• Lowers blood pressure [28-32]
• Boosts brain performance [33-36]
• Improves mood [37-40]
• Improves bone health [41-43]
• Prevents age-related eye disorders [44-49]
• Prevents wrinkles and other signs of skin aging [50-57]
• Accelerates wound healing [58-62]
• Reduces blood sugar levels and treats symptoms of diabetes [63-69]

Proven Health Benefits

Improves Sleep Quality

There are a lot of high-quality studies supporting the primary benefit of melatonin:

1. A review of studies suggested that melatonin treatment was effective in treating sleep disorders. [1]
2. A study showed that melatonin treatment demonstrated significant effects in regulating human circadian rhythm and associated disorders. [2]
3. In patients with primary sleep disorders, melatonin was shown to improve the quality of sleep and showed a potential role in treating insomnia. [3]
4. A review of studies showed the efficacy of melatonin in treating sleep problems without any major side effects. [4]
5. A review of studies presented that melatonin successfully reduced sleep onset, delayed sleep phase syndrome, and regulated the sleeping patterns of blind patients. [5]
6. In blind patients and those who take shifts at work, melatonin was found to be an effective treatment in the resynchronization of their circadian rhythm. [6]
7. A review of studies showed that melatonin treatment produced favorable effects on sleep outcomes. [7]
8. In children with severe chronic sleep disorders, oral melatonin administration improved sleeping patterns. [8]

Lowers Risk of Cardiovascular Disease

Studies show that melatonin can help protect against heart disease:

1. A review of studies showed that melatonin can help treat heart disease related to heart muscle injury and low blood supply. [9]
2. A study has shown that low levels of melatonin were associated with increased risk of heart complications. [10]
3. In patients with cardiovascular diseases, low levels of melatonin were found in patients with coronary artery disorder, arterial hypertension, and congestive heart failure. [11]
4. In patients with heart failure (HF), administration of melatonin reversed the HF-associated pathological processes. [12]
5. In rodents and humans, melatonin’s cardioprotective and anti-oxidative actions limited the frequency of heart failure, heart damage, and abnormal heart functions. [13]

Prevents Cancer

Evidence found that melatonin also has anti-cancer properties:

1. A study showed that melatonin administration weakens cancer by inhibiting its development, progression, and metastasis (spread of cancer cells to different body parts). [14]
2. In rats and human tumor cells, administration of melatonin demonstrated anti-cancer activities. [15]
3. In cancer patients, melatonin administration resulted in improved cancer regression and survival, and better tolerance to chemotherapy. [16]
4. In patients with tumors, melatonin significantly lowered the tumors’ overall survival rate. [17]
5. A review of studies found that melatonin improved the efficacy of chemotherapy with reduced side effects. [18]

Promotes Weight Loss

Melatonin has also been found to be beneficial in overweight and obese patients:

1. In obese patients on a calorie-restricted diet, melatonin supplementation resulted in weight reduction. [19]
2. In postmenopausal women, melatonin administration was associated with weight reduction. [20]
3. A review of studies suggested that melatonin supplementation was more effective for weight reduction in children and adolescents. [21]
4. In mice on a high-fat diet, melatonin administration inhibited body mass gain and attenuated obesity-associated metabolic and inflammatory disorders. [22]
5. In zebrafish models, melatonin treatment produced weight loss and regulated weight gain. [23]

Boosts Immunity

Melatonin can also help strengthen the immune system:

1. A study presented that melatonin could play a potential therapeutic role in enhancing the immune functions of individuals with declining immunity. [24]
2. A review of studies showed that melatonin could be an effective immunostimulant that provides an early immune response against viruses and parasites. [25]
3. A study suggested that the anti-inflammatory and immunomodulatory effects of melatonin can help treat influenza. [26]
4. A study found that melatonin can be considered as a treatment for COVID-19. [27]
5. In mice fed with a high-fat diet, oral supplementation with melatonin protected against metabolic and inflammatory disorders. [22]

Lowers Blood Pressure

Studies suggest that melatonin has anti-hypertensive properties:

1. A review of studies concluded that melatonin was effective in blood pressure regulation. [28]
2. In patients with nocturnal hypertension (NH), melatonin treatment before bedtime significantly lowered systolic blood pressure. [29]
3. In patients with NH, the use of controlled-release melatonin was safe and successful in treating the condition. [30]
4. In diabetic patients with essential hypertension, melatonin treatment restored normal blood pressure. [31]
5. In human and animal studies, melatonin consistently demonstrated its nocturnal BP-lowering effects. [32]

Boosts Brain Performance

Evidence also supports the beneficial effects of melatonin on brain health:

1. In elderly individuals, nightly administration of melatonin was found to be effective in treating age-related cognitive decline. [33]
2. In elderly patients, higher physiological levels of melatonin were found to be associated with reduced occurrence of cognitive impairments and mood disorders. [34]
3. In elderly patients with mild cognitive impairment, administration of immediate-release melatonin safely improved some aspects of their memory without any side effects. [35]
4. In patients who received oral melatonin, significant improvements in symptoms Alzheimer’s disease were observed. [36]

Improves Mood

Melatonin also has mood-boosting properties:

1. In healthy men, it was found that orally administered melatonin exhibited short but significant antidepressant-like effects. [37]
2. In patients with chronic pain, a daily dose of melatonin improved mood and anxiety levels. [38]
3. A study showed that the resynchronization of circadian rhythm from melatonin treatment offers a new strategy in treating depression. [39]
4. In postmenopausal women with appetite disorders, the combined administration of melatonin and fluoxetine resulted in better mood and sleep quality. [40]

Improves Bone Health

Supplementation with melatonin has been found to improve bone health:

1. A study showed that melatonin plays a role in the development of the teeth and bones. [41]
2. In dogs with dental implants, melatonin promoted new bone formation around the titanium implants. [42]
3. In mice with bone disorders, melatonin significantly improved bone mass by enhancing matrix mineralization. [43]

Prevents Age-Related Eye Disorders

Melatonin is also essential for optimum eye health:

1. In patients with age-related macular degeneration (AMD), an eye condition that affects middle vision, daily supplementation of melatonin produced protective effects for the retina and delayed eye degeneration. [44]
2. In rats, melatonin supplementation resulted in reduced risk and severity of retinopathy. [45]
3. A study suggested that the strong antioxidative properties of melatonin present a protective role against AMD. [46]
4. In AMD patients, nightly melatonin supplementation was found to be useful in the treatment of the disease. [47]
5. A study found that melatonin may play a role in the treatment of eye issues like glaucoma and AMD. [48]
6. A study reported that melatonin can help improve eye health by modulating many retinal functions. [49]

Prevents Wrinkles and other Signs of Skin Aging

Studies show that melatonin has anti-aging effects on the skin:

1. A study reported that melatonin exerts its anti-aging effects through its antioxidative properties. [50]
2. In women, skin application of melatonin was found to be effective in improving hydration and tone. [51]
3. In human skin, application of melatonin exerted protective effects against UV-induced solar damage. [52]
4. A study showed that melatonin’s UV protection was able to improve or reverse the signs of skin aging. [53]
5. In rats, melatonin supplementation exhibited anti-aging effects by reducing age-related skin changes. [54]
6. A study reported that decreased levels of melatonin were associated with increased UV-induced DNA damage. [55]
7. In women with aging skin, the application of melatonin-based creams significantly improved skin tonicity and hydration and reduced signs of skin aging. [56]
8. In UV-exposed human skin, nightly application of a melatonin-containing cream significantly decreased skin damage. [57]

Accelerates Wound Healing

Evidence also suggests that melatonin has regenerative properties:

1. In patients with diabetic wounds, melatonin improved wound healing by preventing cell death. [58]
2. In mice, melatonin administration produced beneficial effects in wound healing by improving angiogenesis (the formation of new blood vessels). [59]
3. In rat models, melatonin treatment greatly improved scar formation and quality of wound healing. [60]
4. In diabetic mice, melatonin protected cells against programmed cell death and dysfunction which in turn improved wound healing. [61]
5. In diabetic rats, melatonin accelerated the healing of gastric ulcers. [62]

Reduces Blood Sugar Levels and Treats Symptoms of Diabetes

Melatonin is also beneficial for people with diabetes and elevated blood sugar levels:

1. A study reported that melatonin reduces blood sugar levels by improving insulin secretion. [63]
2. A study showed that melatonin supplementation can treat circadian system disturbance-induced insulin resistance and blood sugar intolerance. [64]
3. A review of studies showed that melatonin administration significantly reduced fasting glucose, a measure of blood sugar. [65]
4. A study also reported that melatonin exerts its anti-diabetic effects by reducing cell death and promoting antioxidant production. [66]
5. In women, lower melatonin secretions were associated with higher risk of type 2 diabetes. [67]
6. A study suggested that melatonin supplementation can help prevent type 2 diabetes caused by disorganized circadian rhythm. [68]
7. A study showed that melatonin could inhibit the development of diabetic complications by regulating the production of free radicals. [69]

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