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Elampretide, also known as elamipretide or SS-31, is a synthetic tetrapeptide that reduces the production of harmful reactive oxygen species in the body. It works by targeting the cell’s powerhouse known as mitochondria which in turn restores various important cellular processes. Studies show that SS-31 has anti-aging effects that are beneficial for the treatment of age-related diseases, genetic disorders, impaired blood circulation, kidney injury, and heart disease.
The mitochondria are known as the “powerhouse of the cell” as they produce the energy required for various cellular processes. Dysfunctional mitochondria can lead to a wide array of inherited mitochondrial diseases and some age-related diseases. In addition, dysfunctional mitochondria produce abnormally high levels of oxidative factors that can significantly damage cardiolipin, a lipid that plays an integral role in the maintenance of the structural integrity of the mitochondria. By binding to cardiolipin, elampretide protects it from the harmful effects of oxidative stress. This in turn prevents or reduces mitochondrial membrane dysfunction and cell death. In addition, the protective effects of elampretide on the mitochondria help restore various important cellular processes.
Studies show that elampretide (SS-31) can help protect against heart disease via different mechanisms:
SS-31 has also been found to improve cognitive function through its ability to protect the neurons (nerve cells) in the brain:
Evidence also found that SS-31’s antioxidant properties and ability to protect the mitochondria from damage may play a role in preventing cancer:
Studies also show that SS-31 is essential for kidney health:
SS-31 has also been found to treat various forms of lung injury:
Elampretide side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on elampretide. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of elampretide. Despite this, it was listed as a side effect associated with elampretide even though these associated side effects are very uncommon.
Side effects associated with elampretide may include the following:
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