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Tesofensine (NS2330) is a serotonin–noradrenaline–dopamine reuptake inhibitor or also known as triple reuptake inhibitor, which means that it inhibits the reabsorption of the neurotransmitters (brain chemicals) serotonin, norepinephrine, and dopamine. This process increases the extracellular concentrations of these neurotransmitters. The therapeutic benefits of tesofensine are attributed to this effect because each of these neurotransmitters exerts an important function at different locations in the brain.
Tesofensine works by boosting the levels of brain chemicals (neurotransmitters) such as dopamine, norepinephrine, and serotonin. Dopamine is associated with the regulation of motor function, mood, motivation, reward, cognitive function, and reproductive behaviors. Norepinephrine increases the force of the contraction of the skeletal muscle and the heart to ensure optimal body function. Serotonin is responsible for the regulation of mood, memory, sleep, and appetite.
Tesofensine is widely known as a weight loss drug. Researchers believe that tesofensine may help treat obese and overweight patients because it boosts the levels of dopamine in the brain. A deficiency in this neurotransmitter has been shown to be linked with overeating and obesity. [1-5] An overwhelming body of human studies supports the fat-burning effect of tesofensine:
Research indicates that tesofensine helps preserve cognitive health by indirectly potentiating cholinergic neurotransmission, which is a process wherein nerve cells relay messages to each other. [24] This has been proven to have beneficial effects on various areas of cognitive health, including learning, memory, and thinking skills. The following studies support this effect:
Sustained treatment with tesofensine has been shown to improve overall mood through its antidepressant effect. Studies show that tesofensine affects mood by:
Tesofensine has also been found to have beneficial effects on blood sugar. Studies show that:
Tesofensine treatment is also beneficial in improving one’s productivity by increasing energy levels. Evidence supports the energy-boosting effects of tesofensine:
Because of its potent antidepressant effect, tesofensine has also been studied for its therapeutic benefits on sexual dysfunction, according to studies:
Studies reported that triple reuptake inhibitor such as tesofensine also holds therapeutic potential for eating disorders:
ADHD is characterized by short attention span, hyperactivity and impulsivity, and is common in children and even adults. Evidence suggests that tesofensine may have beneficial effects on this mental condition:
Studies suggest that tesofensine’s ability to increase the levels of certain neurotransmitters can help improve sleep quality:
There’s also evidence suggesting that tesofensine can cure alcohol addiction via its ability to boost neurotransmitter levels:
Tesofensine side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on tesofensine. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of tesofensine. Despite this, it was listed as a side effect associated with tesofensine even these associated side effects are very uncommon.
Side effects associated with tesofensine may include the following:
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