Pregnenolone is a steroid hormone produced primarily in the adrenal glands. Smaller amounts of pregnenolone are also produced in other organs such as the brain, skin, gonads, liver, and eyes. In the body, all hormones work in harmony to create a healthy balance. If you picture steroid hormones as a cascade, where one hormone has an impact on one another, pregnenolone would be at the top of the cascade.
Pregnenolone is manufactured directly from cholesterol – which is one reason why experts believe that below the normal levels of cholesterol can cause hormonal imbalance. In turn, several other hormones including testosterone, DHEA, estrogen, and cortisol are synthesized from pregnenolone that’s why it is called as the “mother of all steroid hormones”. Just as it’s used to synthesize other steroid hormones, adequate amounts of pregnenolone are used to create neurohormones in the brain, which act to maintain healthy nerve cell function and regulate mood.
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