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Chronic inflammation is one of the most insidious threats to health today—and research is increasingly establishing a link between testosterone deficiency and inflammation. This is especially true for women, who have naturally lower levels of testosterone than men, which may help explain why they are at higher risk for certain inflammatory diseases and autoimmune conditions.
Inflammation is the body’s immune response to harmful stimuli such as damaged cells, pathogens, or irritants. There are two kinds of inflammation: acute and chronic. Acute inflammation is a short-term response to injury. This type of inflammation is characterized by local redness, swelling, and burning. Chronic inflammation, on the other hand, is mostly invisible and occurs inside the body. During this type of inflammatory response, the body releases chemicals into the bloodstream that can cause widespread damage. Chronic inflammation can result from various health conditions, including obesity and diseases like diabetes, as well as stress, lifestyle factors, and others. Once this cycle begins, chronic inflammation has been shown to contribute to many chronic degenerative conditions such as cancer, heart disease, diabetes, hypertension, and stroke. It is also associated with neurodegenerative diseases like Alzheimer’s. Chronic inflammation leads to poor immunity, accelerated aging, weight gain, and chronic pain (such as migraine and joint pain).
While scientists are still learning new information about the causes and implications of chronic inflammation, there is one important area of research that most people are unaware of: the link between low testosterone and inflammation. Chronic inflammation has been shown to lower testosterone levels. In turn, testosterone deficiency actually makes chronic inflammation worse, setting up a negative feedback loop where chronic inflammation and testosterone deficiency reinforce and amplify each other. The end result? Increased risk of chronic diseases from both testosterone deficiency and long-term inflammation.
Testosterone therapy may help ease inflammation in a number of ways. It can suppress phospholipase D, the enzyme that is responsible for the production of pro-inflammatory leukotrienes. It may also help lower pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-6, and increase levels of anti-inflammatory interleukin-10 (IL-10) cytokines.
Testosterone has been shown to offer immunomodulatory benefits in older men. A study involving 473 older male subjects revealed a strong inverse relationship between testosterone and soluble IL-6 receptor levels that may enhance the biological activity of IL-6. Interleukin-6 is a predictor of mortality and disability in older adults.
You may want to consider testosterone therapy if you are suffering from chronic inflammation. Consult with a qualified healthcare practitioner knowledgeable in natural hormone therapy to determine if you’re a good fit for drug-free interventions that are designed to restore hormonal balance.
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