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Amla Fruit

Amla Fruit

Amla fruit, also known as Indian Gooseberry, is a super fruit that is cultivated in all parts of India. It is jam-packed with various nutrients such as vitamin C (20 times more than an orange), proteins, carbohydrates, fiber, iron, calcium, and potassium. It also has an uncommon balance of sweet, sour, bitter, and pungent flavors. Amla can be consumed raw and it’s available in the form of juice and powder.

Overall Health Benefits of Amla Fruit

  • Improves Symptoms of Diabetes [1-3]
  • Lowers Blood Pressure [4]
  • Boosts Sexual Vitality and Improves Sexual Health [5]
  • Speeds Up Wound Healing [6-10]
  • Prevents and Treats Nerve Damage [11-12]
  • Lowers Risk of Stroke [13-15]
  • Improves Kidney Function [16-20]
  • Lowers Risk of Cardiovascular Disease [21-23]
  • Prevents Alzheimer’s Disease (AD) and Boosts Cognitive Health [24-29]
  • Prevents Cancer [30-36]
  • Wards off Depression and Improves Mood [37-38]

How Amla Fruit Exerts its Health Benefits

Amla fruit powder is the purest form of vitamin C. It can improve your blood vessel health as well as immune function. This super fruit is rich in antioxidants, which help fight free radicals in the body and limit cell damage. The antioxidant properties of amla fruit can significantly lower your risk for chronic debilitating medical conditions such as heart disease, cancer, and inflammatory diseases.

Proven Health Benefits of Amla Fruit

Improves Symptoms of Diabetes

Evidence suggests that amla fruit exerts potent anti-diabetic effects:

  1. In diabetic volunteers, amla powder significantly improved high-density lipoprotein-cholesterol and lowered low-density lipoprotein-cholesterol levels. [1]
  2. A study found that amla fruit extract inhibited the production of enzymes responsible for increasing blood sugar levels. [2]
  3. A study reported that amla fruit has phytochemicals that can act as a hypolipidemic agent (reduces blood lipid levels) that could reduce the risk of cardiovascular complications in diabetics [3]

Lowers Blood Pressure

There’s also evidence that shows that the hypolipidemic effect of amla fruit can be beneficial on blood pressure:

  1. A study found that amla produced notable hypolipidemic effect along with a reduction in blood pressure. [4]

Boosts Sexual Vitality and Improves Sexual Health

In animal models, amla fruit has been found to influence sexual behavior:

  1. A study of Drosophila (fruit flies) found that amla fruit may improve sexual behavior. [5]

Speeds Up Wound Healing

Numerous studies also support the regenerative properties of amla fruit:

  1. In a mouse model of arsenic-induced injury, amla fruit reversed injuries associated with toxicity and inflammation. [6]
  2. A study found that amla fruit increased cellular proliferation and collagen migration at the wound site. [7]
  3. A study found that amla tonic can increase the amount of hemoglobin in the blood, suggesting that it can also boost blood circulation at the site of injury. [8]
  4. In human primary dental pulp fibroblasts, amla improved the regeneration of dental tissues. [9]
  5. A study found that amla exerts its regenerative effects through its antioxidant, anti-inflammatory, and anti-ulcer properties. [10]

Prevents and Treats Nerve Damage

There’s increasing evidence supporting the beneficial effects of amla on pain and nerve dysfunction associated with different nerve problems:

  1. A study found that amla has potent analgesic effects in both postoperative and neuropathic pain models. [11]
  2. In an animal model of diabetic neuropathy, amla fruit supplementation improved nerve function by reducing the levels of oxidative stress. [12]

Lowers Risk of Stroke

There’s also a great deal of evidence suggesting that amla fruit consumption can improve cognitive function in stroke:

  1. In male Sprague-Dawley rats, amla fruit supplementation decreased the degeneration of neurons (nerve cells) in the brain. [13]
  2. In rats, amla fruit supplementation improved cognitive performance by increasing the levels of antioxidant enzymes in the brain. [14]
  3. A study found that amla fruit can lower the risk of stroke by reducing lipid levels. [15]

Improves Kidney Function

Studies found that amla fruit can help improve kidney function and reduce the risk of kidney disease:

  1. A study reported that amla can help prevent age-related kidney disease through its antioxidant properties. [16]
  2. In an animal model of kidney disease, amla reduced the levels of harmful free radicals in the kidneys.[17]
  3. In hypothyroid female Wistar rats, treatment with amla fruit extract reduced reactive oxygen species, which cause inflammation and organ damage. [18-20]

Lowers Risk of Cardiovascular Disease

Amla has been found to lower the risk of cardiovascular disease by improving different health parameters:

  1. In obese adults, amla fruit reduced the risk of cardiovascular disease by reducing platelet aggregation. [21]
  2. A study also found that amla extract can prevent heart disease by reducing the levels of total cholesterol and triglycerides. [22]
  3. In rats fed with a high fat diet, supplementation with ethanolic amla extract improved cardiac autonomic functions. [23]

Prevents Alzheimer’s Disease (AD) and Boosts Cognitive Health

An overwhelming body of clinical evidence suggests that amla fruit can help reduce AD and age-related cognitive dysfunction:

  1. In rats, amla protected against aluminum chloride-induced Alzheimer’s disease. [24]
  2. A rat study found that amla can protect against AD and other neurodegenerative diseases by increasing the levels of antioxidant enzymes in the brain. [25]
  3. In rats, amla supplementation reversed aluminum-induced neurotoxicity. [26]
  4. In human subjects, amla supplementation enhanced memory and vitality performance without any adverse effects. [27]
  5. A study reported that amla possesses memory-enhancing effects possibly through its antioxidant and anti-cholinesterase activities. [28]
  6. In rats with diet-induced cognitive impairment, amla fruit supplementation alleviated cognitive dysfunction. [29]

Prevents Cancer

This super fruit also has potent anti-cancer properties which can be beneficial in killing various types of malignant cells in the body:

  1. A study found that the antioxidant properties of amla account for its anticancer activities. [30]
  2. A cell study found that amla fruit can kill cancer cells by inducing programmed cell death (apoptosis). [31]
  3. A cell study showed that amla extract inhibited ovarian cancer cell growth. [32]
  4. A study found that amla exerts its chemotherapy-like effects through its free radical scavenging properties, [33]
  5. A study reported that amla fruit can be an alternative medicine for cancer prevention and treatment. [34]
  6. A cell study found that amla extract can inhibit the growth and multiplication of resistant ovarian cancer cells. [35]
  7. A study found that amla extract can help reduce the risk of cancer by preventing cell instability. [36]

Wards off Depression and Improves Mood

Consumption of amla fruit has also been associated with improvement in mood and reduction of depressive symptoms:

  1. A study found that amla showed antidepressant‐like activity probably by inhibiting MAO‐A and GABA; and also due to its antioxidant activity. [37]
  2. A study also reported that amla fruit exerts its antidepressant effects through its neuroprotective properties. [38]

References:

  1. Akhtar, Muhammad & Ramzan, Ayesha & Ali, Amanat & Ahmad, maqsood_mul. (2011). Effect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. International journal of food sciences and nutrition. 62. 609-16. 10.3109/09637486.2011.560565.
  2. Available from https://onlinelibrary.wiley.com/doi/10.1002/jsfa.10020.
  3. Available from https://www.ijcmas.com/special/5/K.%20V.%20Santhi%20Sri,%20et%20al.pdf.
  4. Gopa B, Bhatt J, Hemavathi KG. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian J Pharmacol. 2012;44(2):238-242. doi:10.4103/0253-7613.93857.
  5. Pathak P, Prasad BR, Murthy NA, Hegde SN. The effect of Emblica officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster. Ayu. 2011;32(2):279-284. doi:10.4103/0974-8520.92544.
  6. Singh, M.K., Yadav, S.S., Yadav, R.S. et al. Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice. SpringerPlus 4, 438 (2015).
  7. Sumitra M, Manikandan P, Gayathri VS, Mahendran P, Suguna L. Emblica officinalis exerts wound healing action through up-regulation of collagen and extracellular signal-regulated kinases (ERK1/2). Wound Repair Regen. 2009;17(1):99-107. doi:10.1111/j.1524-475X.2008.00446.x.
  8. Available from http://www.jorr.org/article.asp?issn=2249-4987;year=2015;volume=7;issue=2;spage=65;epage=68;aulast=Grover.
  9. Baliga MS, Dsouza JJ. Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer. Eur J Cancer Prev. 2011;20(3):225-239. doi:10.1097/CEJ.0b013e32834473f4.
  10. Bulbule AM, Mandroli PS, Bhat KG, Bogar CM. In vitro evaluation of cytotoxicity of Emblica officinalis (amla) on cultured human primary dental pulp fibroblasts. J Indian Soc Pedod Prev Dent 2019;37:251-7.
  11. Gaire, B.P., Subedi, L. Phytochemistry, pharmacology and medicinal properties of Phyllanthus emblica Linn.. Chin. J. Integr. Med. (2014). https://doi.org/10.1007/s11655-014-1984-2.
  12. Lim DW, Kim JG, Kim YT. Analgesic Effect of Indian Gooseberry (Emblica officinalis Fruit) Extracts on Postoperative and Neuropathic Pain in Rats. Nutrients. 2016;8(12):760. Published 2016 Nov 26. doi:10.3390/nu8120760.
  13. Kumar NP, Annamalai AR, Thakur RS. Antinociceptive property of Emblica officinalis Gaertn (Amla) in high fat diet-fed/low dose streptozotocin induced diabetic neuropathy in rats [published correction appears in Indian J Exp Biol. 2009 Oct;47(10):778. Dosage error in article text]. Indian J Exp Biol. 2009;47(9):737-742.
  14. Uddin MS, Mamun AA, Hossain MS, Akter F, Iqbal MA, Asaduzzaman M. Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer’s Disease. Ann Neurosci. 2016;23(4):218-229. doi:10.1159/000449482.
  15. Gopa B, Bhatt J, Hemavathi KG. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian J Pharmacol. 2012;44(2):238-242. doi:10.4103/0253-7613.93857.
  16. Hashem-Dabaghian F, Ziaee M, Ghaffari S, Nabati F, Kianbakht S. A systematic review on the cardiovascular pharmacology of Emblica officinalis Gaertn. J Cardiovasc Thorac Res. 2018;10(3):118-128. doi:10.15171/jcvtr.2018.20.
  17. Takako Yokozawa, Hyun Young Kim, Hyun Ju Kim, Takashi Tanaka, Hidetoshi Sugino, Tsutomu Okubo, Djong-Chi Chu, and Lekh Raj Juneja Journal of Agricultural and Food Chemistry 2007 55 (19), 7744-7752.
  18. Yokozawa, Takako & Kim, Seung & Kim, Hyun & Tanaka, Takashi & Sugino, Hidetoshi & Okubo, Tsutomu & Chu, Djong-Chi & Juneja, Lekh. (2007). Amla ( Emblica officinalis Gaertn.) Attenuates Age-Related Renal Dysfunction by Oxidative Stress. Journal of agricultural and food chemistry. 55. 7744-52. 10.1021/jf072105s.
  19. Vasant RA, Narasimhacharya AV. Amla as an antihyperglycemic and hepato-renal protective agent in fluoride induced toxicity. J Pharm Bioallied Sci. 2012;4(3):250-254. doi:10.4103/0975-7406.99067.
  20. Available from https://www.degruyter.com/view/journals/jbcpp/29/2/article-p175.xml?tab_body=abstract.
  21. Khanna S, Das A, Spieldenner J, Rink C, Roy S. Supplementation of a standardized extract from Phyllanthus emblica improves cardiovascular risk factors and platelet aggregation in overweight/class-1 obese adults. J Med Food. 2015;18(4):415-420. doi:10.1089/jmf.2014.0178.
  22. Upadya, H., Prabhu, S., Prasad, A. et al. A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia. BMC Complement Altern Med 19, 27 (2019). https://doi.org/10.1186/s12906-019-2430-y.
  23. Kanthe PS, Patil BS, Bagali SC, Reddy RC, Aithala MR, Das KK. Protective effects of Ethanolic Extract of Emblica officinalis (amla) on Cardiovascular Pathophysiology of Rats, Fed with High Fat Diet. J Clin Diagn Res. 2017;11(9):CC05-CC09. doi:10.7860/JCDR/2017/28474.10628.
  24. Vishala TC, Pitchaiah G, Pravadha D, Annapurna A. Effect of plain and fortified amla fruit powder on aluminum-induced Alzheimer’s Disease in Wistar Rats. Phcog Res 2019;11:406-9.
  25. Uddin MS, Mamun AA, Hossain MS, Akter F, Iqbal MA, Asaduzzaman M. Exploring the Effect of Phyllanthus emblica L. on Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer’s Disease. Ann Neurosci. 2016;23(4):218-229. doi:10.1159/000449482.
  26. Arokiasamy Justin Thenmozhi, Mathiyazahan Dhivyabharathi, Tharsius Raja William Raja, Thamilarasan Manivasagam & Musthafa Mohamed Essa (2016) Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer’s disease, Nutritional Neuroscience, 19:6, 269-278.
  27. Shah JS, Goyal RK. Usage trends for memory and vitality-enhancing medicines: A pharmacoepidemiological study involving pharmacists of the Gujarat region. Int J Ayurveda Res. 2010;1(3):138-143. doi:10.4103/0974-7788.72484.
  28. Golechha M, Bhatia J, Arya DS. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice. J Environ Biol. 2012;33(1):95-100.
  29. Husain I, Akhtar M, Madaan T, Vohora D, Abdin MZ, Islamuddin M and Najmi AK (2018) Tannins Enriched Fraction of Emblica officinalis Fruits Alleviates High-Salt and Cholesterol Diet-Induced Cognitive Impairment in Rats via Nrf2–ARE Pathway. Front. Pharmacol. 9:23.
  30. Zhao T, Sun Q, Marques M, Witcher M. Anticancer Properties of Phyllanthus emblica (Indian Gooseberry). Oxid Med Cell Longev. 2015;2015:950890. doi:10.1155/2015/950890.
  31. Available from https://cancerres.aacrjournals.org/content/68/9_Supplement/5471.
  32. De A, De A, Papasian C, Hentges S, Banerjee S, Haque I, et al. (2013) Emblica officinalis Extract Induces Autophagy and Inhibits Human Ovarian Cancer Cell Proliferation, Angiogenesis, Growth of Mouse Xenograft Tumors. PLoS ONE 8(8): e72748.
  33. Available from https://www.greenpharmacy.info/index.php/ijgp/article/view/272.
  34. Kumnerdkhonkaen, P., Saenglee, S., Asgar, M.A. et al. Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit. BMC Complement Altern Med 18, 130 (2018).
  35. De A, De A, Sharma R, Suo W, Sharma M. Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets. J Cancer 2020; 11(7):1927-1939. doi:10.7150/jca.36919.
  36. Guo XH, Ni J, Xue JL, et al. Phyllanthus emblica Linn. fruit extract potentiates the anticancer efficacy of mitomycin C and cisplatin and reduces their genotoxicity to normal cells in vitro. J Zhejiang Univ Sci B. 2017;18(12):1031-1045.
  37. Dhingra D, Joshi P, Gupta A, Chhillar R. Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice. CNS Neurosci Ther. 2012;18(5):419-425. doi:10.1111/j.1755-5949.2011.00256.x.
  38. Husain I, Zameer S, Madaan T, et al. Exploring the multifaceted neuroprotective actions of Emblica officinalis (Amla): a review. Metab Brain Dis. 2019;34(4):957-965. doi:10.1007/s11011-019-00400-9.
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