Obesity may significantly impact one’s quality of life, as it can negatively affect independent movement and exercise. While this condition can cause physical and emotional problems, it can also increase one’s risk for deadly diseases such as heart problems, diabetes, cancer, stroke, and non-alcoholic liver failure. Unfortunately, once you become obese, this condition is extremely difficult to reverse or even treat effectively. This is because obesity affects the body’s ability to break down fat stores and use them as a source of energy. In fact, even drugs that have been designed to boost fat breakdown may be ineffective. Therefore, body fat accumulates over time and becomes very challenging to remove without surgical intervention.
Recently, a new breakthrough may help patients with this severe form of obesity achieve a healthier weight. The NNMT inhibitor 5-amino-1-methylquinoline or 5-amino-1MQ has been shown to reduce the production of the enzyme nicotinamide N-methyltransferase (NNMT), a regulator of energy homeostasis in adipose tissue (a type of fat used for energy storage). This mechanism could shrink white adipose tissue and dramatically reduce weight without the need to limit calorie intake.
5-amino-1MQ blocks the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). This process stimulates an increase in the levels of nicotinamide adenine dinucleotide (NAD+), which is involved in a wide array of cellular reactions. The increase in NAD+ levels also increases the body’s metabolic rate, resulting in weight loss. In addition, a gene called sirtuin-1 (SIRT1), also known as ‘the longevity gene’, is also activated. SIRT1 helps lower the risk of debilitating diseases such as diabetes, cardiovascular disease, and cancer.
Evidence suggests that by shrinking white adipose tissue, 5-amino-1MQ can significantly reduce weight and improve body composition:
Studies show that 5-amino-1MQ’s ability to increase NAD+ and activate the SIRT1 gene can help improve cholesterol levels:
Evidence also found that 5-amino-1MQ has beneficial effects on blood sugar levels:
Evidence suggests that the enzyme NNMT is highly associated with inflammatory conditions and related injuries, suggesting that NNMT inhibitors like 5-amino-1MQ may have an anti-inflammatory role:
A number of high-quality studies also suggest that high levels of NNMT are strongly linked with the development of various types of cancer, suggesting a potential therapeutic role for NNMT inhibitors:
Studies suggest that 5-amino-1MQ and other NNMT inhibitors have the potential to treat age-related muscle weakness:
5-amino-1MQ side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on 5-amino-1MQ. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of 5-amino-1MQ. Despite this, it was listed as a side effect associated with 5-amino-1MQ even though these associated side effects are very uncommon.
Side effects associated with 5-amino-1MQ may include the following:
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