Health Benefits Of 5-amino-1MQ

Overall Health Benefits of 5-amino-1MQ

• Produces dramatic weight loss [1-8]
• Fights inflammation [9-14]
• Combats various cancer types [15-29]
• Enhances aged muscle regeneration [30]
• Lowers cholesterol and blood sugar levels [2]

5-amino-1MQ Produces Weight Loss

Evidence suggests that by shrinking white adipose tissue, 5-amino-1MQ can lead to weight loss and improve body composition:

• In U.S. Veterans military service members, administration of 5-amino-1MQ resulted in significant weight loss without any adverse side effects. [1]
• In diet-induced obese mice maintained on a high-fat diet, administration of NNMT inhibitor significantly reduced body weight and white adipose tissue mass, and decreased the size of adipocyte cell (a cell specialized for fat storage) without any observable adverse effects. [2-3]
• Administration of NNMT inhibitor in mice on a high fat diet (HFD) protected against fat accumulation compared with controls. [4]
• Studies also show that NNMT is increased 2-fold in subcutaneous and abdominal adipose tissue of type 2 diabetic men and women compared to healthy controls, suggesting that administration of NNMT inhibitors may reduce body fat. [5-7]
• A cell study found that 5-amino-1MQ prevented lipogenesis (fat formation). [8]

5-amino-1MQ Fights Inflammation

Evidence suggests that the enzyme NNMT is highly associated with inflammatory conditions and related injuries, suggesting that NNMT inhibitors like 5-amino-1MQ may have an anti-inflammatory role:

• Significantly increased levels of NNMT have been observed in the lungs and skeletal muscle of patients with chronic obstructive pulmonary disease (COPD) with muscle wasting. [9-10]
• Increased NNMT levels were also seen in the skeletal muscle of patients with various forms of muscular abnormalities. [11]
• Experimental studies in mice also found an increase in NNMT levels after drug-induced liver injury. [12-13]
• A study found that NNMT production is the body’s protective compensatory response to injury, resulting in inflammatory states. [14]

5-amino-1MQ Combats Various Cancer Types

A number of high quality studies also suggest that high levels of NNMT are strongly linked with the development of various types of cancer, suggesting a potential therapeutic role for NNMT inhibitors:

• NNMT levels are significantly increased in primary glioblastoma tumors (aggressive brain tumors) compared to normal human brain samples. [15]
• Enhanced NNMT production is also increased in human papillary thyroid cancer cell lines. [16]
• In renal clear cell carcinoma, NNMT production is also significantly increased. [17]
• In human bladder cancer, NNMT was found to be a major regulator of cell migration. [18]
• The NNMT protein is also increased in gastric cancers. [19-20]
• NNMT is also identified as a novel serum tumor marker for human colorectal cancers and oral squamous cell carcinoma. [21-22]
• NNMT knockdown (NNMT gene loss) decreased proliferation and migration of bladder cancer cells. [23]
• NNMT knockdown also inhibited the proliferation and/or metastasis of kidney cancer cells, pancreatic cancer cells, and oral squamous carcinoma. [24-26]
• In non-small-cell lung cancer cells, inhibition of NNMT production resulted in suppression of tumor growth. [27]
• Higher levels of NNMT in tumor tissues are associated with lower overall survival rates in cancer patients, suggesting that NNMT inhibitor administration may help improve survival. [28]
• In human oral cancer cell line, administration of NNMT inhibitor dramatically reduced cancer cell growth and reproduction. [29]

5-amino-1MQ Enhances Aged Muscle Regeneration

5-amino-1MQ and other NNMT inhibitors have the potential to help older people with age-related muscle weakness become fitter and stronger, thus allowing them to live an active lifestyle.

A 2019 study published in Biochem Pharmacology found that NNMT inhibitor administration in a group of old mice with senescent muscle stem cells enhanced aged muscle regeneration. [30] In this study, old mice (24 months) underwent barium chloride injection to induce an acute muscle injury. A group of mice were then treated with saline (control) and another group treated with low and high dose of NNMT inhibitor (5 and 10 mg/kg) for 1 week.

Results revealed that regeneration of muscle stem cells (muSCs) were faster in NNMT inhibitor-treated mice, supporting nearly 2-fold greater muscle cell fiber cross-sectional area (CSA) measurements compared with control. In addition, NNMT inhibitor-treated mice exhibited greater contractile function, which is indicative of improved muscle function. These results provide the first clear evidence that NNMT inhibitors can be considered as a therapeutic option for age-related muscle wasting and weakness by rescuing muscle stem cell function and improving skeletal muscle regenerative capacity.

5-amino-1MQ Lowers Cholesterol and Blood Sugar Levels

As a NNMT inhibitor, 5-amino-1MQ’s weight-reducing effects could produce additional benefits such as improvement of cholesterol profile and reduction of blood sugar levels.

A 2018 study published in the Dibetes Journals investigated the effects of NNMT inhibitor in diet-induced obese (DIO) mice maintained on a high-fat diet. [2] During the study period, the researchers assessed different health parameters such as fat mass, oral glucose tolerance, fat cell levels, and circulating lipids.

Interestingly, results showed that systemic treatment of DIO mice with a potent NNMT inhibitor dramatically reduced body weight, fat mass, fat cell size, blood sugar levels, and plasma cholesterol levels. In addition, researchers observed that the treatment did not alter food intake nor produce any adverse side effects. These results suggest that NNMT inhibitors can help improve body composition as well as cholesterol and blood sugar levels.

References:

1. Available from https://apps.dtic.mil/dtic/tr/fulltext/u2/1059191.pdf.
2. Available from https://diabetes.diabetesjournals.org/content/67/Supplement_1/115-LB.
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19. Jang JS, et al. The differential proteome profile of stomach cancer: identification of the biomarker candidates. Oncol Res. 2004;14:491–499.
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22. Sartini D, et al. Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol Med Camb Mass. 2007;13:415–421.
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24. Yu T, et al. Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol. 2015;35:710–721.
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