Both genders can experience androgenetic alopecia, a type of hair loss associated with hormonal decline. This condition can lead to thinning of hair and significant hair loss. While androgenetic alopecia is inevitable, there are effective, non-invasive treatment strategies that can address this condition. Hair loss ointments containing valproic acid and PTD-DBM are considered as the ultimate cosmetic solution to this problem. These two compounds stimulate hair regeneration by speeding up the anagen phase (growth phase).
Valproic acid is an anticonvulsant medication that is primarily used to treat epilepsy, bipolar disorder, neuropathic pain, migraine, attention deficit hyperactivity disorder (ADHD), and other psychological disorders. It exerts its therapeutic effect by affecting certain brain chemicals or neurotransmitters, thus improving overall brain health.
Valproic acid achieves its desired effects through the following important mechanisms:
Treating seizures is the earliest and most prominent use of this anticonvulsant medication, and it is still prescribed for this condition today. Numerous clinical trials support the safety and efficacy of valproic acid in reducing the prevalence of seizure attacks:
Valproic acid is not just indicated for seizure disorders. Evidence suggests that it can help stimulate hair regeneration and treat the root cause of hair loss:
There’s also increasing evidence supporting the pain-relieving properties of valproic acid:
There’s also a good amount of evidence demonstrating the safety and efficacy of valproic acid in stabilizing the mood of patients with various psychological disorders:
Studies also support that valproic acid has positive impact on cognitive health:
PTD-DBM is a man-made peptide which is known to fight hair loss. It exerts its benefits on hair health by affecting the production of the CXXC-type zinc finger protein 5 (CXXC5).
To better understand how PTD-DBM works, it is vital to get a glimpse on the fundamental of hair growth.
Researchers believe that WNT/β-catenin signaling pathways within a cell play a key role in human hair follicle development and hair growth. Normally, these pathways are made of proteins and they transmit several important cell activities and signals to different body systems. Wnt/β-catenin signaling is a key player in stimulating the onset of the anagen or growth phase of hair cycle. When activated, regeneration of the hair follicles takes place. This in turn causes hair to grow in the scalp.
Recently, Korean researchers found that a protein called CXXC5 can interfere with how WNT/β-catenin signaling pathways affect hair growth.  According to the researchers, CXXC5 appears to act as a “negative regulator” on the Wnt/β-catenin pathway, which can impair the anagen phase of hair cycle. Of note, researchers added that subjects who suffer from hair loss have higher levels of CXXC5 in their scalp tissues.
Based on these findings, the researchers developed a biochemical substance known as PTD-DBM which is short for Protein transduction domain (PTD)-Dvl-binding motif (DBM). This new compound promotes hair growth and hair regeneration by inhibiting the production of CXXC5.
The researchers applied PTD-DBM on the bare skin of laboratory mice. After 28 days, new hair follicle growths were observed. When PTD-DBM was applied along with valproic acid, researchers observed faster growth of new hair. These results suggest that the combination of PTD-DBM and valproic acid can address hair loss problems related to aging or other medical conditions.
Evidence suggests that combination treatment of PTD-DBM and valproic acid can also accelerate healing of wounds.
A 2015 study conducted in mice found that the combination of PTD-DBM and valproic acid may help accelerate wound healing.  In this study, researchers created wounds on the dorsal skin of mice and applied PTD-DBM and/or valproic acid on a daily basis in order to stimulate activation of the Wnt/β-catenin pathway. As a positive control, a separate group of mice received epidermal growth factor (EGF), a currently prescribed wound-healing agent.
Researchers observed that treatment with PTD-DBM or valproic acid accelerated wound healing as efficiently as EGF. However, superior wound healing was observed with combination treatment of PTD-DBM and valproic acid compared with EGF alone. In addition, co-treatment with PTD-DBM and valproic acid was associated with significant reduction in inflammatory cells and increase in collagen (promotes wound healing) compared with other groups. Together, these data suggest that combination treatment of PTD-DBM and valproic acid can significantly improve wound healing.
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