Liraglutide

Health Benefits Of Liraglutide

• Treats diabetes [1-7]
• Lowers risk of heart disease [8-16]
• Lowers blood pressure [17-22]
• Helps lose weight [23-28]
• Accelerates wound healing [29-33]
• Prevents cancer [34-37]
• Boosts brain power [38-52]

Treats Diabetes

Several studies support the primary benefit of liraglutide:

1. In diabetic patients, liraglutide significantly improved blood sugar control with a low risk of hypoglycemia (abnormally low blood sugar). [1]
2. In children and adolescents with type 2 diabetes mellitus (T2D), a daily dose of liraglutide produced beneficial effects in controlling blood sugar levels. [2]
3. In patients with type 1 diabetes mellitus (T1D), liraglutide plus insulin treatment was effective at lowering blood sugar levels. [3]
4. In patients with T2D, liraglutide monotherapy or in combination with oral antidiabetic drugs was found to be efficacious and well-tolerated. [4]
5. In patients with T2D, liraglutide treatment was effective in improving the symptoms associated with diabetes. [5]
6. In overweight diabetic patients, liraglutide treatment resulted in reduced risk of complications. [6]
7. In diabetic patients undergoing intensive insulin therapy, liraglutide treatment improved blood sugar control. [7]

Lowers Risk of Heart Disease

Liraglutide has also been found to possess cardioprotective effects:

1. In patients with advanced type 2 diabetes, liraglutide therapy significantly lowered the mortality rate from cardiovascular causes. [8]
2. In diabetic patients, treatment with liraglutide was associated with reduced cases of cardiovascular-related deaths. [9]
3. In patients with type 2 diabetes, liraglutide was shown to have beneficial effects on the function of the heart’s left ventricle. [10]
4. A review of studies reported that liraglutide treatment lowered the risk of heart problems in diabetic patients. [11]
5. In diabetic patients with high cardiovascular risk, liraglutide treatment lowered the cardiovascular outcomes. [12]
6. A study showed that the use of liraglutide was associated with lower risk of major heart diseases. [13]
7. Liraglutide treatment was shown to be beneficial in patients with or without a history of heart failure. [14]
8. In diabetic patients, liraglutide administration greatly lowered the risk of major adverse cardiovascular events. [15]
9. In diabetic patients with coronary artery disease, monotherapy of liraglutide improved cardiovascular function. [16]

Lowers Blood Pressure

Liraglutide can also help lower abnormally high blood pressure:

1. A review of studies showed that liraglutide could significantly reduce blood pressure (BP). [17]
2. In diabetic patients, treatment with liraglutide successfully reduced BP and provided extra cardiovascular benefits. [18]
3. In diabetic patients, liraglutide produced systolic blood pressure (SBP) and weight reduction effects. [19]
4. In diabetic patients with or without antihypertensive medication, liraglutide treatment greatly improved their SBP. [20]
5. In Asian diabetic patients, daily administration of liraglutide resulted in significantly lowered SBP. [21]
6. In patients with type 2 diabetes, liraglutide treatment lowered SBP. [22]

Helps Lose Weight

Taking liraglutide can also lead to weight loss, which can help improve body composition:

1. In patients with heart failure, liraglutide treatment was shown to be effective as a weight-loss agent. [23]
2. In Asian patients, liraglutide produced weight-reducing effects. [24]
3. When combined with a healthy diet and mild exercise, liraglutide was shown to produce significant weight reduction. [25]
4. In obese Chinese patients with type 2 diabetes, daily injection of liraglutide greatly reduced their weight and waist circumference. [26]
5. In obese patients with type 2 diabetes, prolonged liraglutide treatment reduced body weight. [27]
6. In overweight adults with bodyweight-related disease, the addition of liraglutide to a healthy diet and exercise resulted in weight reduction. [28]

Accelerates Wound Healing

Liraglutide is also a great option for the treatment of non-healing wounds:

1. In diabetic mice with skin ulcers, the application of liraglutide-containing ointment improved wound healing. [29]
2. A study suggested that liraglutide can help treat diabetic foot ulcer possibly by reducing blood sugar levels. [30]
3. In patients with diabetic wounds, the application of liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats accelerated the wound repair process. [31]
4. In mice, liraglutide improved wound healing and showed its potential in treating diabetic skin ulcers. [32]
5. In patients with type 2 diabetes, liraglutide treatment was associated with reduced risk of diabetes-related foot ulcer amputations. [33]

Prevents Cancer

Liraglutide has also been shown to possess potent anti-cancer properties:

1. The combined treatment of liraglutide and docetaxel (anti-cancer drug) worked synergistically in reducing the prostate cancer cells’ viability, causing cell cycle arrest, and inducing apoptosis (programmed cell death). [34]
2. A review of studies showed that liraglutide treatment resulted in reduced multiplication of breast cancer cells. [35]
3. A study reported that liraglutide treatment together with metformin produced anti-tumor effects against pancreatic cancer cells. [36]
4. In pancreatic cancer cells, liraglutide inhibited cell proliferation, migration, and invasion. [37]

Boosts Brain Power

A number of convincing studies found that liraglutide has cognitive-enhancing properties:

1. In mice, liraglutide administration produced neuroprotective effects. [38]
2. A study showed that liraglutide has beneficial effects on objective measures of cognitive function. [39]
3. In mice, liraglutide prevented the loss of brain receptors and synapses, and reversed memory impairment induced by Alzheimer’s disease (AD). [40]
4. In medication-induced diabetic mice that exhibited impaired learning and memory, liraglutide treatment attenuated these effects. [41]
5. A study showed that liraglutide can help treat AD by targeting the root cause of the disease. [42]
6. In rats with ovarian cysts, liraglutide treatment reduced memory impairment. [43]
7. In type 2 diabetic rats, liraglutide administration exerted a protective effect against brain cell damage. [44]
8. In diabetic rats with cognitive impairment, liraglutide improved learning and memory. [45]
9. In the mouse model of epilepsy, liraglutide reduced seizure susceptibility and cognitive dysfunction, and exerted neuroprotective effects. [46]
10. A study showed that liraglutide protected against diabetes-induced cognitive impairment. [47]
11. In diabetic mice, liraglutide administration improved cognitive function. [48]
12. In mice fed with a high-fat diet, liraglutide treatment improved metabolic parameters and had a beneficial effect on cognitive function. [49]
13. In a mouse model of Alzheimer’s disease, liraglutide administration significantly increased memory retention and total number of brain neurons. [50]
14. In aged mice, liraglutide reversed memory impairment and synaptic loss, and reduced plaque load. [51]
15. In diabetic patients, liraglutide slowed down memory function decline. [52]

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