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Minoxidil benefits include promoting hair growth, extending the hair growth phase, enhancing hair follicle size, and improving scalp health. This topical solution has shown efficacy in treating various types of hair loss and improving overall hair density and thickness.
Minoxidil is a medication that is applied topically to the scalp to stimulate hair growth and slow balding. Initially used as an oral drug for treating high blood pressure, minoxidil’s hair growth-stimulating properties were discovered incidentally. Today, it is a commonly used treatment for androgenetic alopecia (male and female pattern baldness).
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Minoxidil works by widening blood vessels and opening potassium channels, which allows more oxygen, blood, and nutrients to reach hair follicles. This process stimulates hair follicles, promoting hair growth and extending the growth phase of the hair cycle.
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Minoxidil is chemically known as 2,4-diamino-6-piperidinopyrimidine 3-oxide. It is a vasodilator, which means it helps dilate blood vessels, thereby improving blood flow.
Research studies have consistently shown that minoxidil promotes hair growth by stimulating hair follicles and extending the anagen (growth) phase of the hair cycle. By improving blood flow to the hair follicles, minoxidil helps in reviving shrunken hair follicles, allowing them to increase in size and produce thicker hair strands.
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Minoxidil prolongs the anagen phase of the hair cycle, allowing hair to grow longer and thicker. By extending this growth phase, minoxidil helps in maintaining hair density and preventing hair thinning.
Minoxidil helps in increasing the size of hair follicles, which is crucial for producing thicker hair strands. This effect is particularly beneficial for individuals with miniaturized hair follicles due to androgenetic alopecia.
Minoxidil has been shown to improve scalp health by increasing blood flow and nutrient delivery to hair follicles. This enhanced circulation helps create a healthier environment for hair growth.
Minoxidil is generally well-tolerated, but some users may experience side effects. Common side effects include scalp irritation, itching, and dryness. In rare cases, users may experience more severe reactions such as rapid heart rate, chest pain, or dizziness. It is important to follow the recommended dosage and consult with a healthcare provider if any severe side effects occur.
Minoxidil is a popular treatment for promoting hair growth, particularly in individuals experiencing androgenetic alopecia, commonly known as male or female pattern baldness. It works by stimulating the hair follicles and prolonging the anagen phase, or growth phase, of the hair cycle. This results in new hair growth and the thickening of existing hair strands, making it an effective solution for those looking to combat thinning hair.
The application of Minoxidil is straightforward, typically available in liquid or foam form for topical use. Users are advised to apply it directly to the scalp in the areas affected by hair loss, usually twice a day. Consistency is key to achieving the best results, as it can take several months of regular use before significant improvements are visible. The ease of application and the non-invasive nature of Minoxidil make it a convenient option for many individuals.
Minoxidil’s effectiveness has been well-documented, earning it FDA approval as a treatment for hair loss. This approval underscores its safety and efficacy, providing users with confidence in its use. While Minoxidil can lead to notable hair growth and slow down hair loss, it is essential to maintain continued use to sustain these benefits. Stopping the treatment can result in a gradual return to the previous state of hair loss. As a widely recognized and accessible treatment, Minoxidil offers a reliable solution for those seeking to improve their hair growth and combat the effects of alopecia.
Topical Minoxidil is a widely used treatment for hair loss, particularly effective in cases of androgenetic alopecia, also known as male or female pattern baldness. Applied directly to the scalp, Minoxidil works by stimulating hair follicles and promoting new hair growth. The ease of application in either liquid or foam form makes it a convenient option for those experiencing thinning hair or significant hair loss.
The primary mechanism of Minoxidil involves increasing blood flow to the scalp. This enhanced circulation delivers more oxygen and nutrients to hair follicles, encouraging them to enter the growth phase and produce thicker, stronger hair strands. Users typically start seeing visible results within three to six months of consistent application, making it a relatively quick-acting solution compared to other hair loss treatments.
One of the key benefits of topical Minoxidil is its FDA approval, which underscores its efficacy and safety. This approval assures users that Minoxidil has undergone rigorous testing and meets specific standards for treating hair loss. However, it’s important to note that the effectiveness of Minoxidil can vary among individuals, and continuous use is necessary to maintain hair growth benefits. Discontinuation of the treatment often results in the gradual loss of newly regrown hair. For personalized advice, consulting a doctor specializing in dermatology or hair restoration is recommended.
Minoxidil 5 is a topical medication specifically formulated with a 5% concentration of minoxidil, an active ingredient widely used for treating hair loss. It is commonly available in both liquid and foam forms, making it convenient for application to the scalp. The higher concentration of minoxidil in this formulation is designed to be more effective in promoting hair regrowth and slowing the progression of hair loss in individuals suffering from androgenetic alopecia, also known as male or female pattern baldness.
The mechanism by which Minoxidil 5 works involves stimulating hair follicles and increasing blood flow to the scalp. This enhanced circulation provides hair follicles with more oxygen and nutrients, which are essential for hair growth. As a result, users often experience thicker and stronger hair over time. Clinical studies have demonstrated that the 5% concentration is more effective than lower concentrations, providing significant benefits for those dealing with hereditary hair loss.
Minoxidil 5 is generally well-tolerated, though some users may experience mild side effects such as scalp irritation or dryness. It is important to apply the medication consistently and as directed to achieve the best results. While Minoxidil 5 can significantly improve hair density and reduce hair loss, it is most effective when used early in the hair loss process and requires ongoing use to maintain the benefits. As an FDA-approved treatment, Minoxidil 5 offers a reliable and effective option for individuals seeking to manage and treat hair loss.
Minoxidil, widely known for its use in treating scalp hair loss, has gained popularity for promoting beard growth. By enhancing blood flow to the hair follicles, Minoxidil stimulates dormant or weak hair follicles in the facial region, encouraging the development of new beard hair. This is particularly beneficial for individuals with patchy or thin beards, as consistent application can lead to fuller and more even beard growth over time.
The application process for Minoxidil on the beard is straightforward and similar to its use on the scalp. Users typically apply the solution or foam to their clean, dry face, focusing on areas where they desire increased hair growth. It is important to use the product consistently, usually twice a day, and to follow up with thorough hand washing to avoid unintentional contact with other body areas. Results can vary, but many users start to see noticeable improvements in beard density and coverage within three to six months of regular use.
While Minoxidil is generally safe, potential side effects can include skin irritation, dryness, and itching at the application site. It is recommended to start with a lower concentration to assess skin tolerance and gradually increase if needed. Users should also be aware that discontinuing Minoxidil may result in the gradual loss of newly grown beard hair. Consulting with a healthcare professional before beginning a Minoxidil regimen for beard growth is advisable to ensure it is appropriate and to discuss any concerns about side effects or interactions with other treatments.
Introduction to Minoxidil Pills Minoxidil pills, originally developed as an oral medication for high blood pressure, have gained attention for their off-label use in treating hair loss. Unlike the topical application, doctor minoxidil pills work systemically, potentially offering a more comprehensive approach to stimulating hair growth. By expanding doctor blood vessels and improving circulation, the oral form of minoxidil enhances nutrient delivery to hair follicles, promoting hair regrowth in individuals experiencing various types of alopecia.
Benefits and Efficacy The systemic nature of doctor minoxidil pills allows for uniform distribution of the medication throughout the body, which can be particularly beneficial for individuals with extensive hair loss. Some studies and anecdotal evidence suggest that oral minoxidil might be more effective in certain cases where topical applications have not yielded satisfactory results. Additionally, oral administration may be more convenient for those who find the twice-daily application of topical minoxidil cumbersome.
Considerations and Side Effects Despite the potential benefits, doctor minoxidil pills come with a range of considerations and possible side effects. Common side effects include fluid retention, increased heart rate, and unwanted hair growth on other parts of the body. It is crucial for individuals considering oral minoxidil to consult with a healthcare professional to evaluate the risks and benefits based on their specific health conditions. Due to the potency and systemic impact of doctor minoxidil pills, proper dosing and medical supervision are essential to minimize adverse effects and ensure safe and effective treatment.
Minoxidil tablets, initially developed to treat high blood pressure, have garnered attention for their off-label use in addressing hair loss. Unlike the topical solution, minoxidil tablets work systemically by dilating blood vessels, which improves blood flow throughout the body, including the scalp. This enhanced circulation can stimulate hair follicles and promote hair growth, making the tablets an alternative for those who might not respond to or prefer not to use the topical form.
The efficacy of minoxidil tablets in treating hair loss has shown promising results in various studies and clinical trials. Patients using the oral form have reported significant improvements in hair density and overall hair health. However, the systemic nature of the tablets means that they can have more widespread effects, which necessitates careful monitoring by healthcare professionals to manage potential side effects such as low blood pressure, fluid retention, and heart-related issues.
Despite its benefits, the use of minoxidil tablets for hair loss is not yet approved by the FDA, and more research is needed to fully understand its safety and long-term effects. Physicians typically prescribe minoxidil tablets off-label, and the decision to use them should be based on a thorough discussion of the potential risks and benefits. Patients considering this treatment should do so under the guidance of a healthcare provider to ensure appropriate dosing and to mitigate any adverse effects.
Minoxidil foam is a popular formulation used to treat hair loss, particularly in individuals with androgenetic alopecia, commonly known as male or female pattern baldness. It offers a convenient application method compared to liquid solutions, as it does not drip and is easier to spread evenly across the scalp. This foam formulation typically contains 5% minoxidil, the active ingredient known for its ability to stimulate hair follicles and promote hair regrowth.
The application process for minoxidil foam involves dispensing a capful onto the fingers and then gently massaging it into the scalp where hair thinning is occurring. This method ensures that the medication reaches the hair follicles directly, where it can exert its effects. Users are advised to apply minoxidil foam twice daily, consistently over several months, to achieve noticeable results in hair growth and reduction of hair loss.
Minoxidil foam is well-tolerated by most users, with side effects generally limited to mild scalp irritation or dryness, which can be minimized by following proper application techniques and using moisturizing products as needed. Its effectiveness and ease of use have made minoxidil foam a preferred choice for many individuals seeking to combat hair thinning and promote thicker, healthier hair growth.
Oral minoxidil has emerged as an alternative treatment for hair loss, particularly for individuals who may not respond well to topical formulations. Unlike its topical counterpart, oral minoxidil works systemically by dilating blood vessels and increasing blood flow, thereby promoting hair growth across the scalp. This method is particularly beneficial for patients with extensive hair loss or those experiencing significant thinning, as it can potentially yield more widespread results compared to topical applications.
Despite its effectiveness, oral minoxidil requires careful monitoring due to potential side effects such as fluid retention and low blood pressure. Physicians typically prescribe lower doses initially, gradually increasing as tolerated to minimize adverse effects. This approach helps balance therapeutic benefits with safety considerations, ensuring patients receive optimal hair regrowth while managing any potential health risks associated with systemic medication.
Research continues to explore oral minoxidil’s efficacy and safety profile in various populations, including those with specific medical conditions or genetic predispositions to hair loss. As a prescription-only medication, its use is guided by healthcare professionals to tailor treatment plans based on individual needs and health status, emphasizing the importance of personalized care in managing hair loss effectively with oral minoxidil.
Finasteride and Minoxidil are two widely recognized treatments for hair loss, each with distinct mechanisms and benefits. Finasteride, an oral medication, works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone into dihydrotestosterone (DHT). By reducing DHT levels in the scalp, Finasteride helps to slow down hair loss and promote hair regrowth in men with male pattern baldness. It is typically taken daily and has been shown to be effective in a significant percentage of users, though it may have side effects such as sexual dysfunction in a small number of cases.
On the other hand, Minoxidil is a topical solution or foam applied directly to the scalp. Unlike Finasteride, which targets hormonal pathways, Minoxidil’s exact mechanism in promoting hair growth is not fully understood. However, it is known to widen blood vessels and increase blood flow to the hair follicles, thereby enhancing their function and stimulating hair growth. Minoxidil is suitable for both men and women and is available over-the-counter in various strengths. It requires regular application to maintain its effects, and while generally well-tolerated, some users may experience scalp irritation as a side effect.
Both Finasteride and Minoxidil can complement each other in a comprehensive approach to treating hair loss. While Finasteride addresses hormonal factors that contribute to hair thinning and loss, Minoxidil directly enhances the environment around hair follicles, promoting healthier and thicker hair growth. The combination of these treatments may offer synergistic benefits for individuals seeking effective solutions to combat hair loss and improve hair density. Consulting with a healthcare provider or dermatologist is recommended to determine the most suitable treatment plan based on individual needs and considerations.
Yes, minoxidil has been clinically proven to promote hair regrowth in individuals with androgenetic alopecia (male pattern baldness) and female pattern hair loss. It stimulates hair follicles, leading to thicker and fuller hair over time with regular use. Using low dose oral minoxidil has also shown efficacy in some cases, particularly when topical treatments are not effective enough to stimulate hair growth in the desired areas.
One disadvantage of minoxidil topical solution is that it may cause scalp irritation and dryness, especially in the early stages of treatment. Additionally, minoxidil topical solution requires a consistent application to maintain its effectiveness, and discontinuing its use can lead to a reversal of hair regrowth.
Minoxidil is generally not recommended for individuals under 18 years old or those with a history of hypersensitivity to the medication. It should also be used with caution by pregnant or breastfeeding women unless advised by a healthcare provider. When using topical minoxidil, it’s important to follow recommended guidelines and consult a healthcare provider if there are any concerns about its use.
Minoxidil primarily improves hair density and thickness by revitalizing hair follicles, increasing blood flow to the scalp, and extending the hair growth phase. Oral minoxidil treatment helps to slow down hair loss and stimulate new hair growth in areas affected by pattern baldness.
No, minoxidil topical foam does not provide permanent hair growth. It requires continuous use of minoxidil solution to sustain its effects. If treatment with minoxidil solution is stopped, hair regrowth may diminish, and hair loss may resume.
Yes, minoxidil solution can help grow existing hair by increasing the diameter and length of hair shafts. It revitalizes weakened hair follicles, leading to thicker and healthier hair over time.
Yes, many users experience noticeable hair regrowth results with minoxidil solution, typically within a few months of consistent use. Results can vary depending on individual factors such as the extent of hair loss and adherence to treatment.
Yes, minoxidil works effectively when applied topically to the scalp. It is available in various formulations such as liquid, foam, or solution, which are applied directly to the affected areas to stimulate hair follicles and promote hair regrowth.
Common downsides of minoxidil include scalp irritation, dryness, and initial shedding of hair during the early stages of treatment. Some users may also experience unwanted hair growth in areas where minoxidil comes into contact with skin other than the scalp. Minoxidil works by stimulating blood flow to the scalp, which can enable hair follicles to grow thicker and healthier hair over time.
Topical minoxidil therapy should be avoided by individuals with a history of allergic reactions to the medication or its ingredients. It is generally not recommended for use by pregnant or breastfeeding women without medical advice.
No, topical minoxidil sulfate is available over-the-counter in various strengths (typically 2% or 5%) and does not require a prescription for purchase. However, it is advisable to consult a healthcare provider before starting minoxidil sulfate treatment, especially for individuals with underlying medical conditions.
No, minoxidil is not a steroid. It is a vasodilator medication that works by widening blood vessels and increasing blood flow to the scalp, thereby promoting hair growth in individuals with hair loss conditions. Topically applied minoxidil is effective when used consistently to stimulate hair follicles and improve hair density. It’s important to consult with a doctor before starting any new treatment regimen involving minoxidil.
Minoxidil enhances hair growth by prolonging the anagen (growth) phase of hair follicles, increasing follicular size, and improving blood circulation to the scalp. It revitalizes dormant follicles and encourages thicker hair growth over time.
Yes, applying minoxidil is beneficial for hair as it helps to improve hair density, thickness, and overall scalp health. Minoxidil response testing involves the examination of dermal papilla cells, which play a crucial role in hair follicle function. It is effective in treating male pattern baldness and female pattern hair loss when used as directed. Minoxidil stimulates dermal papilla cells, promoting hair growth and increasing follicle size. It is effective in treating male pattern baldness and female pattern hair loss when used as directed. Minoxidil works by revitalizing dermal papilla cells, thereby extending the hair growth phase and preventing hair thinning.
Minoxidil 5% is a higher concentration formulation that is more potent than the 2% solution. Balding patients typically use it to treat moderate to severe hair loss and have found it more effective in promoting hair regrowth in clinical studies. For balding patients, this higher concentration is often recommended by doctors for better results in hair restoration.
Common side effects of minoxidil include scalp irritation, dryness, itching, and temporary hair shedding during the initial stages of treatment. Less common side effects may include dizziness, rapid heartbeat, and unwanted hair growth on other parts of the body. Minoxidil can also sometimes cause skin rashes, especially in individuals with sensitive skin. If you experience persistent skin rashes while using minoxidil, consult your doctor for advice.
Yes, minoxidil can regrow hair by stimulating hair follicles, increasing hair thickness, and prolonging the growth phase of hair. It is effective in treating androgenetic alopecia and other forms of hair loss when used consistently. Remember, consistency is key to seeing results, and a missed dose can affect its effectiveness. It’s important to consult with a doctor before starting any new treatment regimen to ensure it’s suitable for your specific condition and needs. A doctor can also provide guidance on the proper application and dosage of minoxidil to maximize its benefits.
Minoxidil 5% is typically applied twice daily to the scalp, once in the morning and once at night. Consistent use is essential to achieve and maintain hair regrowth benefits. It’s crucial not to miss a dose of Minoxidil 5%, as consistency is key to its effectiveness. Remembering each application helps ensure you don’t miss a dose and maximize the potential for hair regrowth. If a dose is missed, apply the next dose as soon as possible and continue with the regular schedule to maintain optimal results.
Yes, minoxidil has been used off-label to stimulate beard growth in individuals with patchy or thin facial hair. It works similarly to how it promotes scalp hair growth by revitalizing hair follicles and increasing blood flow to the facial hair area. However, consistency is key in achieving results, and missing a dose can impact the effectiveness of the treatment. It’s important to follow the recommended application schedule to avoid setbacks due to missed doses.
The permanence of beard gains with minoxidil can vary among individuals. Continued use is generally required to maintain beard growth, as discontinuation may lead to a reversal of the effects over time. It’s crucial not to miss a dose of minoxidil to sustain the progress achieved. Consistency in application helps prevent setbacks that could occur if a missed dose interrupts the regimen. Regular application minimizes the risk of experiencing reduced effectiveness due to a missed dose of minoxidil.
Yes, minoxidil can help fix a patchy beard by promoting new hair growth and increasing hair density in areas with sparse or uneven facial hair. Randomized clinical trial data supports its efficacy in such cases. It is important to use it consistently and as directed for best results. Randomized clinical trial evidence suggests that minoxidil application can significantly improve beard thickness and coverage over time.
Yes, minoxidil used on the beard area may cause similar side effects as when used on the scalp, including dryness, itching, and irritation. Some users may also experience unwanted hair growth in unintended areas of the face. It’s important to note that prolonged use of minoxidil on facial hair can potentially contribute to traction alopecia, a condition where constant pulling or tension on hair follicles leads to gradual hair loss. Therefore, it’s advisable to use minoxidil for facial hair growth under careful supervision and following recommended usage guidelines to minimize the risk of traction alopecia.
Oral minoxidil pills can be effective in treating severe cases of hypertension and may also be used off-label for hair loss, including cases of non scarring alopecia. However, they are associated with potentially serious side effects and are generally considered a second-line treatment for hair loss, especially in cases of non scarring alopecia, after topical minoxidil and finasteride.
Oral minoxidil can cause significant side effects such as fluid retention, low blood pressure, and cardiac complications. Telogen effluvium requires close monitoring by a healthcare provider and is typically reserved for cases where topical treatments have not been effective.
The timeline for hair growth with oral minoxidil, like other drugs, can vary widely among individuals. Some may notice hair regrowth within a few months, while others may require longer periods of treatment to see noticeable results.
Yes, weight gain is a potential side effect of oral minoxidil due to its effects on fluid retention and metabolic changes. However, for the most upregulated target gene, not all individuals will experience weight gain, and its occurrence can vary in severity.
Oral minoxidil tablets can be effective in promoting hair growth in a dose dependent manner, especially in individuals who have not responded well to topical treatments like minoxidil solutions or foams. However, they are associated with significant side effects and should be used with caution. It’s important to monitor the effects of oral minoxidil tablets in a dose dependent manner to minimize risks and optimize benefits.
Oral minoxidil can cause weight gain primarily due to its effects on fluid retention and sodium retention, which can lead to increased body weight. It may also alter metabolic processes, contributing to weight changes in some individuals.
A minoxidil 2.5 mg tablet is typically used for treating hypertension (high blood pressure). It works by relaxing blood vessels, thereby lowering blood pressure. It is not typically used for hair loss treatment. Patients prescribed this medication should adhere to a regular dosing schedule to effectively manage blood pressure. It’s important to consult with a doctor before starting or changing any medication regimen.
Minoxidil foam is considered as effective as the liquid solution for promoting hair growth. Its pharmacological properties make it easier to apply and less likely to cause scalp irritation compared to the liquid formulation. When choosing between the two options, consulting with a doctor can provide valuable insights into which formulation may be more suitable for individual needs.
Minoxidil foam should be left on the scalp for at least 4 hours after application to ensure absorption into the skin. It should not be washed off or rinsed out during this time. Remember to apply minoxidil after washing your hands and ensuring your scalp is dry for effective results. Apply minoxidil evenly across the affected areas of the scalp, ensuring thorough coverage for optimal absorption.
Yes, minoxidil foam is effective in regrowing hair by stimulating hair follicles, increasing blood flow to the scalp, and prolonging the growth phase of hair. It helps to improve hair density and thickness with regular use. Minoxidil foam can be used alongside other medications to enhance its effectiveness. Minoxidil foam applied to the lower legs can also stimulate hair growth in those areas. Minoxidil foam has been shown to grow continuously, stimulating hair growth in those areas.
Oral minoxidil pills and minoxidil foam are used for different purposes and cannot be directly compared for effectiveness in hair growth. Postural hypotension Oral minoxidil may be more effective in some cases of severe hair loss but is associated with more significant side effects compared to topical minoxidil foam. Postural hypotension Oral minoxidil foam, on the other hand, is generally well-tolerated and convenient to use, making it a preferred choice for many individuals seeking hair regrowth treatments.
Major side effects of minoxidil can include severe scalp irritation, allergic reactions, unwanted hair growth in unintended areas, and in rare cases, systemic effects such as dizziness or rapid heartbeat. It is important to monitor for these effects, as they are the most common side effect, and seek medical attention if they occur.
When used as directed, minoxidil is generally considered safe for most people. However, it may cause side effects in some individuals, particularly scalp irritation or unwanted hair growth. Pregnant or breastfeeding women should consult a healthcare provider before using minoxidil to evaluate its potential treatment implications.
The most troublesome effect of minoxidil for many users is scalp irritation and dryness, especially during the initial stages of treatment. This can be managed by adjusting the affected area’s low dose or frequency of application as recommended by a healthcare provider.
Oral minoxidil can be effective in promoting hair growth, particularly in cases where topical treatments have not been successful. However, it is associated with significant side effects, including cardiovascular issues and cell proliferation concerns, and requires close monitoring by a healthcare provider. The development of safer formulations through drug design approaches could mitigate these concerns and improve treatment outcomes.
Weight gain is a common side effect of oral minoxidil due to its effects on fluid retention and metabolic changes. The extent of weight gain can vary among individuals and may require adjustments in diet and lifestyle to manage. This weight gain is similar to the effects seen in many medications, and can often be managed through dietary changes and increased physical activity. Many medications that affect fluid retention and metabolic processes can lead to weight gain, requiring adjustments in diet and lifestyle to manage effectively.
The best oral medication for hair loss depends on individual factors such as the cause and severity of hair loss, as well as personal health considerations. Finasteride, often prescribed for male pattern baldness, is typically taken daily, with the next dose to be taken at the scheduled time. Oral minoxidil, another option used off-label for hair loss treatment, requires careful monitoring of the next dose timing due to its blood pressure effects. Each medication has its own benefits and risks, so consulting with a healthcare provider is essential to determine the next dose and the most suitable treatment plan.
Combining minoxidil and finasteride can provide complementary benefits in treating hair loss. Minoxidil stimulates hair follicles and promotes growth, while finasteride blocks the hormone responsible for shrinking hair follicles. Consulting with a healthcare provider can help determine the best combination and dosage for individual needs. It’s important to follow the prescribed regimen and monitor any potential side effects, such as dry scalp or irritation. Using cool water to rinse hair can also enhance the effectiveness of these treatments by maintaining scalp health and promoting circulation.
Finasteride is considered worth the risk for many individuals with male pattern baldness, as it effectively slows down hair loss and promotes regrowth in a significant percentage of users. However, it may cause sexual side effects in a small number of cases, which should be weighed against its benefits.
Yes, finasteride can regrow hair by blocking the hormone DHT (dihydrotestosterone), which contributes to hair follicle shrinkage and hair loss in individuals with male pattern baldness. It helps to maintain existing hair and promote thicker hair growth over time. Finasteride works by inhibiting the enzyme 5-alpha reductase, which converts testosterone into DHT. By reducing DHT levels, it supports the survival of dp cells hair follicles and encourages hair regrowth.
Combining minoxidil with finasteride may increase the risk of side effects such as scalp irritation or sexual dysfunction compared to using each medication alone. It is important to discuss potential risks and benefits with a healthcare provider before starting combination therapy. Before considering this treatment approach, conducting a systematic review of existing literature on the subject can provide valuable insights into the overall safety and efficacy profile.
Olsen, E. A., Weiner, M. S., Delong, E. R., & Pinnell, S. R. (1985). Topical minoxidil in early male pattern baldness. Journal of the American Academy of Dermatology, 13(2), 185-192.
Topical minoxidil in early male pattern baldness
In a 12-month double-blind, controlled trial involving 126 men with early male pattern baldness, 2% and 3% topical minoxidil were tested against a placebo, showing significant increases in terminal hair growth after 4 months; the placebo group also showed increased hair growth when switched to minoxidil, with no net hair loss observed in the target area.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(85)70157-0/abstract.
Lucky, A. W., Piacquadio, D. J., Ditre, C. M., Dunlap, F. E., Kantor, I., Pandya, A. G., & Tharp, M. D. (2004). A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. Journal of the American Academy of Dermatology, 50(4), 541-553.
A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss
In a 48-week double-blind, placebo-controlled, randomized trial involving 381 women with female pattern hair loss, 5% topical minoxidil was found to be superior to 2% topical minoxidil and placebo in promoting hair growth, as measured by nonvellus hair count and patient/investigator assessments, with both concentrations showing improved psychosocial perceptions; however, the 5% solution had a higher incidence of pruritus, local irritation, and hypertrichosis.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(03)04317-2/abstract.
Fenton DA, Wilkinson JD. Topical minoxidil in the treatment of alopecia areata. Br Med J (Clin Res Ed). 1983 Oct 8;287(6398):1015-7. doi: 10.1136/bmj.287.6398.1015. PMID: 6412929; PMCID: PMC1549582.
Topical minoxidil in the treatment of alopecia areata
A modified double-blind crossover study with 30 patients showed that 1% topical minoxidil significantly promoted hair regrowth in alopecia areata, with 16 patients achieving a cosmetically acceptable response and no observed side effects, although it was less effective in more severe cases like alopecia totalis and universalis.
You can read the abstract of the article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1549582/.
Dermatology and Therapy. (2022). Efficacy and safety of oral minoxidil 5 mg once daily in the treatment of male patients with androgenetic alopecia: An open-label and global photographic assessment.
Efficacy and safety of oral minoxidil 5 mg once daily in the treatment of male patients with androgenetic alopecia: An open-label and global photographic assessment.
A study on 30 men with androgenetic alopecia treated with oral minoxidil 5 mg daily for 24 weeks showed a significant increase in hair counts and notable improvement in hair growth, especially in the vertex area, with common side effects being hypertrichosis and pedal edema, and no serious cardiovascular adverse events observed.
You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649170/.
Archives of Dermatological Research. (2021). Efficacy and safety of combinational therapy using topical minoxidil and microneedling for the treatment of androgenetic alopecia: a systematic review and meta-analysis.
Efficacy and safety of combinational therapy using topical minoxidil and microneedling for the treatment of androgenetic alopecia: a systematic review and meta-analysis
Androgenetic alopecia affects 58% of men and 40% of women by age 50, causing significant distress. A systematic review and meta-analysis of ten randomized controlled trials with 466 patients found that combining topical minoxidil with microneedling significantly increased total hair count compared to minoxidil alone, but did not significantly increase hair diameter. No serious adverse events were reported, suggesting that this multimodal approach is effective for hair growth, though further large-sample trials are needed to confirm these findings.
You can read the abstract of the article at https://link.springer.com/article/10.1007/s00403-023-02688-1.
Journal of Cosmetic Dermatology. (2022). Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population.
Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population
A study of 40 female patients with female pattern hair loss found that combining 2% minoxidil with weekly microneedling was significantly more effective (85% effective rate) than minoxidil alone (45% effective rate) over 24 weeks, with higher hair counts in the combined group and only mild adverse reactions in both groups, indicating the safety and efficacy of the combined treatment.
You can read the full article at https://onlinelibrary.wiley.com/doi/10.1111/jocd.15424.
Clinical and Experimental Dermatology. (2018). A pilot split-scalp study of combined fractional radiofrequency microneedling and 5% topical minoxidil in treating male pattern hair loss.
A pilot split-scalp study of combined fractional radiofrequency microneedling and 5% topical minoxidil in treating male pattern hair loss
A randomized, controlled, split-scalp trial with 19 Chinese men showed that combining fractional radiofrequency microneedling (FRM) with 5% topical minoxidil significantly improved hair count and thickness compared to using minoxidil alone, indicating that the combined treatment could be an effective and safe option for male pattern hair loss.
You can read the abstract of the article at https://academic.oup.com/ced/article-abstract/43/7/775/6597272?redirectedFrom=fulltext&login=false.
International Journal of Trichology. (2017). A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia.
A comparative study of microneedling with platelet-rich plasma plus topical minoxidil (5%) and topical minoxidil (5%) alone in androgenetic alopecia
A study comparing the efficacy of topical minoxidil (5%) alone versus combined with microneedling and platelet-rich plasma (PRP) in men with androgenetic alopecia (AGA) found significant improvement in hair growth and patient satisfaction in the combined treatment group after six months, as assessed by both patients and physicians.
You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514790/.
Frontiers in Medicine. (2022). Efficacy and safety of 5% minoxidil alone, minoxidil plus oral spironolactone, and minoxidil plus microneedling on female pattern hair loss: a prospective, single-center, parallel-group, evaluator blinded, randomized trial.
Efficacy and safety of 5% minoxidil alone, minoxidil plus oral spironolactone, and minoxidil plus microneedling on female pattern hair loss: a prospective, single-center, parallel-group, evaluator blinded, randomized trial
A study involving 120 women with mild-to-moderate female pattern hair loss (FPHL) found that combining topical minoxidil (MX) with microneedling (MN) significantly improved hair density more than MX alone or MX combined with oral spironolactone (SPT). While all treatments increased hair shaft diameter and dermis thickness, the MX + MN group showed the greatest improvements in hair density and average hair follicle diameter. The MX + SPT group reported the most adverse effects. Overall, MX combined with MN was deemed the most effective and safest treatment option.
You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309533/.
ISHRS. (2021). One-year observational study on the effectiveness of 5% minoxidil in treating male-pattern hair loss.
One-year observational study on the effectiveness of 5% minoxidil in treating male-pattern hair loss.
Androgenetic alopecia (AGA) is a common type of hair loss characterized by receding frontal hairlines in men and diffuse thinning in women, impacting quality of life. It is driven by 5‐alpha‐reductase and dihydrotestosterone (DHT), leading to hair follicle miniaturization and shortened growth cycles. Treatment options include FDA-approved therapies like minoxidil, finasteride, and low-level light therapy, alongside numerous other medical, surgical, and nutraceutical approaches. Selection of appropriate treatments involves balancing efficacy, side effects, compliance, and costs, highlighting the complexity of managing this chronic condition ethically and effectively.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298335/.
JAMA Dermatology. (2017). Interventions for female pattern hair loss.
Interventions for female pattern hair loss
A comprehensive review of 47 trials involving 5290 participants examined various treatments for female pattern hair loss (FPHL). The study found that topical minoxidil significantly increased hair regrowth compared to placebo, with no notable difference between 2% and 5% concentrations. Finasteride was not more effective than placebo, and laser therapy showed inconsistent results. The review highlighted a need for more randomized controlled trials on other treatments such as spironolactone, finasteride at different dosages, dutasteride, cyproterone acetate, and laser-based therapy.
You can read the full article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457957/.
Dermatology and Therapy. (2011). A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women.
A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women
A study comparing once-daily 5% minoxidil topical foam (MTF) to twice-daily 2% minoxidil topical solution (MTS) in women with androgenetic alopecia found that 5% MTF was noninferior in efficacy for hair growth and offered significant advantages in terms of aesthetics and practicality, with fewer side effects such as pruritus and dandruff.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(10)01811-6/abstract.
Journal of the European Academy of Dermatology and Venereology. (2018). Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version.
Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version
Androgenetic alopecia is the most common hair loss disorder, affecting up to 80% of Caucasian men and 42% of women, and can significantly impair quality of life. The European Dermatology Forum (EDF) developed evidence-based guidelines to assist dermatologists in choosing effective and safe therapies for this condition, based on a systematic review of current therapeutic options and expert consensus.
You can read the full article at https://onlinelibrary.wiley.com/doi/10.1111/jdv.14624.
Journal of the American Academy of Dermatology. (2019). Androgens in women: Hormone-modulating therapies for skin disease.
Androgens in women: Hormone-modulating therapies for skin disease
Androgen-mediated cutaneous disorders (AMCDs) in women, such as acne, hirsutism, and female pattern hair loss, can be treated with hormone-modulating therapies like combined oral contraceptives, spironolactone, finasteride, dutasteride, and flutamide. This article reviews these treatments, their mechanisms, safety profiles, contraindications, monitoring parameters, and efficacy evidence. It highlights the need for more rigorous studies to evaluate these therapies, some of which are FDA-approved and others used off-label.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(18)32673-2/abstract.
British Journal of Dermatology. (2005). Treatment of female pattern hair loss with oral antiandrogens.
Treatment of female pattern hair loss with oral antiandrogens
This study aimed to evaluate the efficacy of oral antiandrogen therapy for female pattern hair loss (FPHL) and identify predictive clinical and histological parameters. Eighty women with biopsy-confirmed FPHL received either spironolactone or cyproterone acetate for a minimum of 12 months. Standardized photographs were used to assess changes. Results showed that 88% of women had no progression or improvement in hair density, with 44% experiencing regrowth. The only significant predictor of response was a higher midscalp clinical grade. The study concludes that oral antiandrogens can stabilize or improve FPHL, though a placebo-controlled study is needed for comparison.
You can read the abstract of the article at https://academic.oup.com/bjd/article-abstract/152/3/466/6636418?redirectedFrom=fulltext.
Rossi, A., Cantisani, C., Melis, L., Iorio, A., Scali, E., & Calvieri, S. (2012). Minoxidil use in dermatology, side effects and recent patents. Recent Patents on Inflammation & Allergy Drug Discovery, 6(2), 130-136.
Minoxidil use in dermatology, side effects and recent patents
Minoxidil, initially an oral medication for high blood pressure, was found to stimulate hair growth, leading to its development as a topical treatment for androgenic alopecia. Available in 2% and 5% concentrations, it requires regular application to maintain hair growth, with measurable changes disappearing months after discontinuation. Its exact mechanism is unclear, but it is believed to enhance blood flow and nutrient delivery to hair follicles. Common side effects include scalp irritation and allergic reactions, often due to propylene glycol. Increased hair shedding during use is due to hair cycle synchronization induced by the treatment.
You can read the abstract of the article at https://www.eurekaselect.com/article/41603.
Tsuboi, R., Arano, O., Nishikawa, T., Yamada, H., & Katsuoka, K. (2007). Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men. Journal of Dermatology, 34(10), 645-654.
Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men
A study with 300 Japanese male patients with androgenetic alopecia compared the efficacy of 5% topical minoxidil to 1% topical minoxidil over 24 weeks. The 5% minoxidil group showed a significantly greater increase in non-vellus hair density compared to the 1% group, confirming its superior efficacy. Adverse events occurred in 8.7% of the 5% group and 5.3% of the 1% group, with no significant difference in incidence.
You can read the abstract of the article at https://onlinelibrary.wiley.com/doi/10.1111/j.1346-8138.2009.00673.x.
Messenger, A. G., Rundegren, J. (2004). Minoxidil: mechanisms of action on hair growth. British Journal of Dermatology, 150(2), 186-194.
Minoxidil: mechanisms of action on hair growth
Minoxidil stimulates hair growth by shortening the telogen phase and promoting earlier entry into the anagen phase, likely prolonging anagen and increasing hair follicle size. Its precise mechanism is unclear, but it may involve the opening of potassium channels by its sulphated metabolite. Despite its effects on cell proliferation, collagen synthesis, and growth factor production, the application of these findings to hair follicle biology remains uncertain. Further research is needed to fully understand minoxidil’s action on hair growth.
You can read the abstract of the article at https://academic.oup.com/bjd/article-abstract/150/2/186/6635785?redirectedFrom=fulltext&login=false.
Kavak, A., Yeşildal, N., Parlak, A. H., Gökdemir, G., & Aydoğan, I. (2008). Combination of oral finasteride and topical minoxidil in male androgenetic alopecia. Journal of the European Academy of Dermatology and Venereology, 22(3), 385-389.
Combination of oral finasteride and topical minoxidil in male androgenetic alopecia
A study compared the effectiveness of combining 5% minoxidil (MNX) lotion with 0.25% topical finasteride (F) spray versus each treatment alone for androgenetic alopecia (AGA). Group A (MNX + F) showed significantly higher hair density improvements and global photographic scores compared to groups using MNX or F alone. The combination therapy demonstrated superior clinical efficacy without notable differences in side effects or hormonal levels, suggesting it as a promising approach for AGA treatment.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/37798906/#:~:text=Purpose%3A%20Topical%20minoxidil%20(MNX),associated%20with%20the%20oral%20formula.
Dhurat, R., & Saraogi, P. (2009). Hair evaluation methods: merits and demerits. International Journal of Trichology, 1(2), 108.
Hair evaluation methods: merits and demerits
Various methods for evaluating hair loss are categorized into non-invasive, semi-invasive, and invasive techniques, each with unique advantages and limitations. Non-invasive methods include questionnaires, hair counts, and imaging techniques, while semi-invasive methods involve trichograms, and invasive methods require scalp biopsies. While no single method is ideal or feasible for all situations, when used cautiously, they are valuable for diagnosing and monitoring hair loss. Some methods, like global photography, are essential in clinical settings, while others, like phototrichograms, are typically used in clinical trials.
You can read the full article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938572/.
Ablon, G. (2016). A 12-month, randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of a new topical formulation containing 5% minoxidil for the treatment of androgenetic alopecia in men. Journal of the American Academy of Dermatology, 75(4), 706-712.
A 12-month, randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of a new topical formulation containing 5% minoxidil for the treatment of androgenetic alopecia in men
16-week, double-blind, placebo-controlled trial with 352 men aged 18 to 49 showed that a new 5% minoxidil topical foam (MTF) formulation significantly increased hair counts and improved subjective hair loss assessments compared to placebo. The 5% MTF was well tolerated over a 52-week period, suggesting it is a safe and effective treatment for androgenetic alopecia in men.
You can read the abstract of this article at
https://pubmed.ncbi.nlm.nih.gov/17761356/
Blume-Peytavi, U., Hillmann, K., Dietz, E., & Canfield, D. (2007). A randomized, single-blind, placebo-controlled study evaluating the efficacy and safety of topical minoxidil foam in the treatment of androgenetic alopecia in women. Journal of the American Academy of Dermatology, 57(5), 767-774.
A randomized, single-blind, placebo-controlled study evaluating the efficacy and safety of topical minoxidil foam in the treatment of androgenetic alopecia in women
In a 48-week, double-blind, placebo-controlled, randomized trial involving 381 women with female pattern hair loss, 5% topical minoxidil was found to be superior to placebo and 2% minoxidil in promoting hair growth and improving scalp coverage, with both concentrations being well-tolerated but the higher concentration associated with more local side effects.
You can read the abstract of this article at
https://pubmed.ncbi.nlm.nih.gov/15034503/.
Berger, R. S., & Fu, J. L. (1990). A placebo-controlled trial of topical minoxidil in the treatment of androgenetic alopecia. Journal of Investigative Dermatology, 95(5), 501-505.
A placebo-controlled trial of topical minoxidil in the treatment of androgenetic alopecia
In a 48-week, double-blind, placebo-controlled trial involving 393 men with androgenetic alopecia, 5% topical minoxidil was found to be significantly more effective than 2% minoxidil and placebo in increasing hair regrowth and improving patient perceptions of hair loss, with an earlier response and greater magnitude of effect, although it caused more local irritation.
You can read the abstract of this article at
https://pubmed.ncbi.nlm.nih.gov/12196747/.
Tang, P. H., Chia, H. P., & Cheong, W. K. (2002). A study on the efficacy and safety of topical minoxidil in the treatment of male pattern hair loss in Asians. Journal of Dermatology, 29(11), 779-783.
A study on the efficacy and safety of topical minoxidil in the treatment of male pattern hair loss in Asians
A study on low-dose oral minoxidil for male androgenetic alopecia (AGA) showed significant hair growth improvement over 24 weeks, with notable increases in hair counts and positive photographic assessments, especially in the vertex area. Common side effects included hypertrichosis and pedal edema, but no serious cardiovascular issues were reported, indicating good overall safety.
You can read the abstract of this article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649170/.
De Villez, R. L., Jacobs, J. P., Szpunar, C. A., & Gomez, E. B. (1994). Androgenetic alopecia in the female: treatment with 2% topical minoxidil solution. Archives of Dermatology, 130(3), 303-307.
Androgenetic alopecia in the female: treatment with 2% topical minoxidil solution
In a 32-week, double-blind, placebo-controlled trial involving 308 women with androgenetic alopecia, 2% topical minoxidil significantly increased the number of nonvellus hairs compared to placebo. On average, the minoxidil group saw an increase of 23 hairs per cm², while the placebo group saw an increase of 11 hairs. Moderate hair growth was reported by 13% of minoxidil users and 6% of placebo users. No serious or unexpected medical events were observed.
You can read the abstract of the article at https://jamanetwork.com/journals/jamadermatology/article-abstract/555638.
Munck, K., & Gavazzoni Dias, M. F. R. (2011). A double-blind, placebo-controlled trial of 5% topical minoxidil for the treatment of androgenetic alopecia in men. Journal of the American Academy of Dermatology, 64(4), 617-624.
A double-blind, placebo-controlled trial of 5% topical minoxidil for the treatment of androgenetic alopecia in men
A 48-week study comparing 5% and 2% topical minoxidil solutions with a placebo found that 5% minoxidil significantly outperformed both 2% minoxidil and placebo in increasing hair regrowth and improving patient perceptions of hair loss. The 5% solution resulted in a 45% greater hair regrowth than the 2% solution and elicited an earlier response. Both concentrations were well tolerated, though the 5% solution caused more local irritation.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/12196747/.
Orentreich, N., Durr, N. P., & Labib, A. M. (1990). Topical minoxidil therapy for androgenetic alopecia: a preliminary report. Journal of the American Academy of Dermatology,
Topical minoxidil therapy for androgenetic alopecia: a preliminary report
In a double-blind, placebo-controlled study with 72 male patients using 2% to 3% topical minoxidil for androgenetic alopecia, hair regrowth was observed in all treatment groups by four months, peaking at 12 months. At 30 months, hair counts had decreased from the 12-month peak but remained above baseline, with 70% of patients maintaining at least 50% more hair than at the start. No systemic side effects were reported.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/3314717/.
Price, V. H. (1999). Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata. Journal of the American Academy of Dermatology, 41(4), 600-603.
Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata
In a 32-week, double-blind, placebo-controlled trial involving 308 women with androgenetic alopecia, 2% topical minoxidil significantly increased the number of nonvellus hairs compared to placebo. On average, the minoxidil group saw an increase of 23 hairs per cm², while the placebo group saw an increase of 11 hairs. Moderate hair growth was reported by 13% of minoxidil users and 6% of placebo users. No serious or unexpected medical events were observed.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(87)70095-4/abstract.
Draelos, Z. D., & Tang, L. (2004). A new topical minoxidil formulation with a botanical extract improves hair growth in women with androgenetic alopecia: a double-blind, placebo-controlled study. Journal of the American Academy of Dermatology, 50(6), 763-769.
A new topical minoxidil formulation with a botanical extract improves hair growth in women with androgenetic alopecia: a double-blind, placebo-controlled study
A 32-week, double-blind, placebo-controlled trial involving 346 women across 10 European centers found that a 2% topical minoxidil solution significantly increased nonvellus hair count and new hair growth compared to a placebo, with no serious medical events reported, demonstrating its effectiveness and safety for treating androgenetic alopecia in women.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/8225725/.
Feily, A., & Faghihi, G. (2008). Topical minoxidil in the treatment of alopecia areata. Journal of the European Academy of Dermatology and Venereology, 22(9), 1087-1092.
Topical minoxidil in the treatment of alopecia areata
In a modified double-blind crossover study involving 30 patients with alopecia areata and alopecia totalis, 1% topical minoxidil significantly induced hair regrowth, with 16 patients achieving a cosmetically acceptable response. No side effects were observed. However, minoxidil was less effective in more severe cases, such as alopecia universalis and totalis, where patients may not respond at all. Overall, minoxidil is relatively non-toxic, easy to use, and free of systemic or local side effects
You can read the abstract of the article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1549582/.
Olsen, E. A., & Whiting, D. (2005). Topical minoxidil in the treatment of androgenetic alopecia: results of a two-year study. Journal of the American Academy of Dermatology, 52(2), 292-293.
Topical minoxidil in the treatment of androgenetic alopecia: results of a two-year study
A 48-week, double-blind, placebo-controlled trial found that 5% topical minoxidil significantly outperformed 2% minoxidil and placebo in promoting hair regrowth and improving psychosocial perceptions in men with androgenetic alopecia, despite increased local irritation.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/12196747/.
Dommasch, E. D., & Gelfand, J. M. (2014). Efficacy and safety of topical minoxidil in the treatment of female pattern hair loss: a meta-analysis. Journal of Investigative Dermatology, 134(12), 296-304.
Efficacy and safety of topical minoxidil in the treatment of female pattern hair loss: a meta-analysis
In a 48-week study of 381 women with female pattern hair loss, 5% topical minoxidil showed superior efficacy over both 2% minoxidil and placebo in promoting hair growth and improving hair count and scalp coverage, with some increased local irritation. Both concentrations were well tolerated and improved psychosocial perceptions of hair loss.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/15034503/.
Tosti, A., & Piraccini, B. M. (2001). Topical minoxidil in the treatment of hair disorders. Dermatologic Clinics, 19(2), 387-395.
Topical minoxidil in the treatment of hair disorders
Low-dose oral minoxidil has emerged as a well-tolerated and effective alternative to topical minoxidil for treating various hair disorders, including androgenetic alopecia and alopecia areata, offering improved compliance despite the need for further research to determine optimal dosing and treatment protocols.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Singh, M. K., & Yadav, K. S. (2013). Efficacy of combination therapy with minoxidil and aminexil in androgenetic alopecia. Journal of Cosmetic Dermatology, 12(1), 32-39.
Efficacy of combination therapy with minoxidil and aminexil in androgenetic alopecia
A meta-analysis and systematic review of 15 randomized controlled trials involving 1172 patients found that combination therapies of minoxidil with finasteride, low-level laser light therapy (LLLT), or microneedling are more effective than minoxidil alone for treating androgenetic alopecia (AGA), showing significant improvements in global photographic assessment and hair count. However, further research is needed to confirm these findings.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/32478968/.
Badri, T., Hammami, H., & Benmously, R. (2010). Topical minoxidil in the treatment of alopecia universalis: a pilot study. Journal of Dermatology, 37(4), 298-301.
Topical minoxidil in the treatment of alopecia universalis: a pilot study. Journal of Dermatology, 37(4), 298-301
A modified double-blind crossover study of 30 patients with alopecia areata and alopecia totalis found that 1% topical minoxidil significantly induced hair regrowth, with 16 patients achieving a cosmetically acceptable response and no side effects observed. However, minoxidil was less effective in severe cases, particularly in alopecia universalis and totalis.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/6412929/.
Burg, D., & Goulden, V. (1997). Topical minoxidil in the treatment of diffuse alopecia areata. Journal of the American Academy of Dermatology, 37(4), 673-676.
Topical minoxidil in the treatment of diffuse alopecia areata
A modified double-blind crossover study found that 1% topical minoxidil significantly induced hair regrowth in patients with alopecia areata, with 16 out of 30 patients achieving cosmetically acceptable results and no side effects observed; however, it was less effective for more severe forms of the disease such as alopecia universalis and totalis.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/6412929/#:~:text=The%20study%20confirmed%20that%20topical,more%20severe%20and%20extensive%20disease.
Blumeyer, A., Tosti, A., & Messenger, A. (2011). Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version. Journal of the European Academy of Dermatology and Venereology, 25(12), 146-156.
Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men – short version
Androgenetic alopecia, the most common hair loss disorder affecting men and women, typically begins in the teenage years and progresses with age, impacting up to 80% of Caucasian men and 42% of women, often leading to significant quality of life impairment. The European Dermatology Forum (EDF) has developed evidence-based guidelines for its treatment, providing dermatologists with a systematic tool for selecting effective and safe therapies based on a comprehensive literature review and consensus recommendations.
You can read the full article at https://onlinelibrary.wiley.com/doi/10.1111/jdv.14624.
Piraccini, B. M., & Alessandrini, A. (2014). Topical minoxidil in the treatment of hair disorders. Journal of the American Academy of Dermatology, 70(6), 1174-1176.
Topical minoxidil in the treatment of hair disorders
Low-dose oral minoxidil has emerged as an effective and well-tolerated alternative to topical minoxidil for treating various hair disorders, including androgenetic alopecia, telogen effluvium, and alopecia areata. Despite its benefits, further large-scale studies are needed to determine the optimal dosing and treatment duration, with current evidence suggesting women need lower doses (0.25-2.5 mg daily) than men (1.25-5 mg daily).
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Blume-Peytavi, U., & Hillmann, K. (2008). Randomized, double-blind, placebo-controlled study of topical minoxidil in the treatment of female pattern hair loss. Journal of the American Academy of Dermatology, 59(6), 817-824.
Randomized, double-blind, placebo-controlled study of topical minoxidil in the treatment of female pattern hair loss
In a 48-week study involving 381 women with female pattern hair loss, the efficacy and safety of 5% topical minoxidil were compared to 2% minoxidil and a placebo. Results showed that 5% minoxidil was significantly more effective than placebo in promoting hair growth, as measured by nonvellus hair count and patient/investigator assessments of hair growth and scalp coverage. The 2% minoxidil also demonstrated superiority over placebo in some measures but not in patient assessment of hair growth. Both concentrations were well tolerated, though higher concentrations led to more local side effects like itching and irritation compared to placebo and 2% minoxidil.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/15034503/.
Piraccini, B. M., & Pazzaglia, M. (2011). Topical minoxidil in the treatment of hair disorders. Journal of Investigative Dermatology, 131(2), 318-320.
Topical minoxidil in the treatment of hair disorders
The study reviews the use of low-dose oral minoxidil as an alternative to topical minoxidil in treating various hair disorders. It highlights its efficacy and safety across conditions like androgenetic alopecia, telogen effluvium, and others, suggesting it as a viable option particularly for patients with adherence issues to topical treatments. The review calls for more extensive studies to establish optimal dosing and treatment protocols, emphasizing varied responses in men and women to different dosage ranges.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Van Neste, D., & Rushton, D. H. (2004). Hair growth and hair loss: advances in basic research and clinical aspects. Journal of the American Academy of Dermatology, 50(6), 933-937.
Hair growth and hair loss: advances in basic research and clinical aspects.
The abstract discusses hair loss as a prevalent issue with significant mental and psychological impact. It covers types of hair loss, including androgenetic alopecia, alopecia areata, and telogen effluvium, focusing on androgenetic alopecia as the most common. Traditional treatments like minoxidil and finasteride, along with surgical options such as hair transplantation, have limitations, prompting exploration into hair follicle development, regeneration, and emerging therapies like low-level laser therapy, micro needling, and stem cell therapy. The review emphasizes understanding hair follicle structure, development cycles, and current treatments, highlighting regenerative medicine as promising for managing hair loss.
You can read the abstract of the article at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750333/.
Fenton, D. A., & Wilkinson, J. D. (1983). Topical minoxidil in the treatment of androgenetic alopecia. Journal of the American Academy of Dermatology, 8(4), 608-612.
Topical minoxidil in the treatment of androgenetic alopecia
In a 32-week study across 11 US centers, 308 women with androgenetic alopecia were treated with a 2% topical minoxidil solution. Compared to placebo, minoxidil resulted in a significant increase of 23 nonvellus hairs per 1-cm² site versus 11 hairs for placebo. Moderate growth was observed in 13% of the minoxidil group versus 6% in the placebo group, with 60% of minoxidil users reporting new hair growth. No adverse vital sign changes or serious medical events were noted. The study concludes that 2% topical minoxidil is effective for treating female androgenetic alopecia.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/8129407/#:~:text=No%20clinically%20significant%20changes%20in,treatment%20of%20female%20androgenetic%20alopecia.
Price, V. H. (1999). Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata. Journal of the American Academy of Dermatology, 41(4), 600-603.
Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata
A double-blind study evaluating 3% topical minoxidil for treating extensive patchy alopecia areata, alopecia totalis, and alopecia universalis involved 30 subjects applying the treatment to half their scalp for one year. The treatment was well tolerated except for three cases of scalp itching and dermatitis. Hair growth was observed in 63.6% of the minoxidil group compared to 35.7% of the placebo group, with cosmetically acceptable growth in 27.3% of minoxidil users versus 7.1% of placebo users. No systemic effects were noted, though some minoxidil users had detectable serum levels of the drug.
You can read the abstract of the article at https://www.jaad.org/article/S0190-9622(87)70095-4/abstract.
Tosti, A., & Piraccini, B. M. (2001). Topical minoxidil in the treatment of hair disorders. Dermatologic Clinics, 19(2), 387-395.
Topical minoxidil in the treatment of hair disorders
In a 32-week study across 11 US centers, 308 women with androgenetic alopecia were treated with a 2% topical minoxidil solution. Compared to placebo, minoxidil resulted in a significant increase of 23 nonvellus hairs per 1-cm² site versus 11 hairs for placebo. Moderate growth was observed in 13% of the minoxidil group versus 6% in the placebo group, with 60% of minoxidil users reporting new hair growth. No adverse vital sign changes or serious medical events were noted. The study concludes that 2% topical minoxidil is effective for treating female androgenetic alopecia.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Feily, A., & Faghihi, G. (2008). Topical minoxidil in the treatment of alopecia areata. Journal of the European Academy of Dermatology and Venereology, 22(9), 1087-1092.
Topical minoxidil in the treatment of alopecia areata
A modified double-blind crossover study with 30 patients showed that 1% topical minoxidil significantly induced hair regrowth in alopecia areata, with 16 patients achieving cosmetically acceptable results and no side effects. However, it was less effective in severe cases like alopecia totalis and universalis. Minoxidil was found to be non-toxic, easy to use, and free of systemic or local side effects compared to other treatments.
You can read the abstract of the article at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1549582/.
Tosti, A., & Pazzaglia, M. (2010). Topical minoxidil in the treatment of hair disorders. Journal of Investigative Dermatology, 130(7), 164-167.
Topical minoxidil in the treatment of hair disorders
Oral minoxidil has emerged as a viable alternative to topical minoxidil for treating various hair disorders, including androgenetic alopecia and others like telogen effluvium and alopecia areata. This review highlights its efficacy and safety based on existing literature, advocating for standardized studies to optimize treatment protocols regarding dosage and duration. While promising, further research is needed to determine the optimal use of oral minoxidil, particularly in differentiating dosing needs between men and women.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Goodfellow, A., & Dawber, R. (1990). Topical minoxidil in the treatment of androgenetic alopecia: results of a two-year study. Journal of the American Academy of Dermatology, 22(2), 242-246.
Topical minoxidil in the treatment of androgenetic alopecia: results of a two-year study
In this study, researchers compared the efficacy of 5% topical minoxidil, 2% topical minoxidil, and placebo in treating androgenetic alopecia (AGA) in men over 48 weeks. They found that 5% topical minoxidil significantly outperformed both 2% minoxidil and placebo in increasing nonvellus hair count, improving scalp coverage according to patient and investigator assessments, and enhancing psychosocial perceptions of hair loss. Although 5% minoxidil showed superior efficacy, it also led to more pruritus and local irritation compared to 2% minoxidil.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/12196747/.
Harrison, S., & Bergfeld, W. (2009). Topical minoxidil in the treatment of hair disorders. Journal of Investigative Dermatology, 129(6), 147-154.
Topical minoxidil in the treatment of hair disorders
The study examines oral minoxidil as a viable alternative to topical treatments for various hair disorders, citing effectiveness and patient adherence issues with topical minoxidil. It reviews studies across conditions like androgenetic alopecia, alopecia areata, and others, suggesting oral minoxidil’s efficacy and tolerability. The need for further research on optimal dosing and treatment protocols, especially in larger randomized studies, is highlighted to establish standardized guidelines.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/33660357/#:~:text=Topical%20minoxidil%20has%20been%20used,%2C%20cost%20and%20side%2Deffects.
Price, V. H., & Menefee, E. (1996). Topical minoxidil in the treatment of alopecia areata. Journal of the American Academy of Dermatology, 35(2), 216-217.
Topical minoxidil in the treatment of alopecia areata
In a study comparing 1% topical minoxidil with placebo in 30 patients with alopecia areata and alopecia totalis, the active treatment significantly promoted hair regrowth, with a cosmetically satisfactory outcome observed in 16 patients. No adverse effects were reported. The findings suggest that while minoxidil effectively induces hair growth in alopecia areata, its efficacy diminishes in more severe cases such as alopecia universalis and totalis. Despite its limitations in severe forms, topical minoxidil is considered safe, user-friendly, and lacks systemic or local side effects compared to other treatments.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/6412929/#:~:text=The%20study%20confirmed%20that%20topical,may%20not%20respond%20at%20all.
Tang, L., & Draelos, Z. D. (2004). A new topical minoxidil formulation with a botanical extract improves hair growth in women with androgenetic alopecia: a double-blind, placebo-controlled study. Journal of the American Academy of Dermatology, 50(6), 763-769.
A new topical minoxidil formulation with a botanical extract improves hair growth in women with androgenetic alopecia: a double-blind, placebo-controlled study
The study evaluated the effectiveness of 2% topical minoxidil solution versus placebo in treating androgenetic alopecia in women through a 32-week trial across European centers. Results showed a significant increase in nonvellus hair count among those using minoxidil compared to placebo, with 44% achieving new hair growth versus 29% in the placebo group. Participant self-assessment also favored minoxidil, indicating its efficacy and safety in treating this condition.
You can read the abstract of the article at
https://pubmed.ncbi.nlm.nih.gov/8225725/.
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